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Gene: INE1 |
Gene summary for INE1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | INE1 | Gene ID | 8552 |
| Gene name | inactivation escape 1 | |
| Gene Alias | NCRNA00010 | |
| Cytomap | Xp11.3 | |
| Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 8552 | INE1 | HCC1 | Human | Liver | HCC | 2.10e-06 | 1.87e+00 | 0.5336 |
| 8552 | INE1 | HCC2 | Human | Liver | HCC | 2.78e-04 | 7.61e-01 | 0.5341 |
| 8552 | INE1 | HCC5 | Human | Liver | HCC | 2.57e-02 | 4.34e-01 | 0.4932 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0007568110 | Skin | SCCIS | aging | 41/919 | 339/18723 | 9.54e-08 | 1.29e-05 | 41 |
| GO:009752916 | Skin | SCCIS | myeloid leukocyte migration | 31/919 | 220/18723 | 1.20e-07 | 1.52e-05 | 31 |
| GO:0007160110 | Skin | SCCIS | cell-matrix adhesion | 32/919 | 233/18723 | 1.38e-07 | 1.70e-05 | 32 |
| GO:004001315 | Skin | SCCIS | negative regulation of locomotion | 44/919 | 391/18723 | 2.61e-07 | 2.61e-05 | 44 |
| GO:2001236112 | Skin | SCCIS | regulation of extrinsic apoptotic signaling pathway | 24/919 | 151/18723 | 3.42e-07 | 3.03e-05 | 24 |
| GO:005092114 | Skin | SCCIS | positive regulation of chemotaxis | 23/919 | 141/18723 | 3.72e-07 | 3.23e-05 | 23 |
| GO:0010810111 | Skin | SCCIS | regulation of cell-substrate adhesion | 30/919 | 221/18723 | 4.35e-07 | 3.67e-05 | 30 |
| GO:000268517 | Skin | SCCIS | regulation of leukocyte migration | 29/919 | 210/18723 | 4.69e-07 | 3.77e-05 | 29 |
| GO:2001234112 | Skin | SCCIS | negative regulation of apoptotic signaling pathway | 30/919 | 224/18723 | 5.83e-07 | 4.62e-05 | 30 |
| GO:0045861112 | Skin | SCCIS | negative regulation of proteolysis | 40/919 | 351/18723 | 6.58e-07 | 5.13e-05 | 40 |
| GO:000268717 | Skin | SCCIS | positive regulation of leukocyte migration | 22/919 | 135/18723 | 6.75e-07 | 5.19e-05 | 22 |
| GO:000716217 | Skin | SCCIS | negative regulation of cell adhesion | 36/919 | 303/18723 | 8.82e-07 | 6.24e-05 | 36 |
| GO:200014616 | Skin | SCCIS | negative regulation of cell motility | 40/919 | 359/18723 | 1.17e-06 | 7.78e-05 | 40 |
| GO:003362714 | Skin | SCCIS | cell adhesion mediated by integrin | 15/919 | 72/18723 | 1.73e-06 | 9.54e-05 | 15 |
| GO:005127116 | Skin | SCCIS | negative regulation of cellular component movement | 40/919 | 367/18723 | 2.04e-06 | 1.09e-04 | 40 |
| GO:006104119 | Skin | SCCIS | regulation of wound healing | 21/919 | 134/18723 | 2.31e-06 | 1.17e-04 | 21 |
| GO:190204119 | Skin | SCCIS | regulation of extrinsic apoptotic signaling pathway via death domain receptors | 12/919 | 49/18723 | 3.12e-06 | 1.49e-04 | 12 |
| GO:0052547112 | Skin | SCCIS | regulation of peptidase activity | 46/919 | 461/18723 | 4.09e-06 | 1.82e-04 | 46 |
| GO:000195219 | Skin | SCCIS | regulation of cell-matrix adhesion | 20/919 | 128/18723 | 4.19e-06 | 1.82e-04 | 20 |
| GO:003033615 | Skin | SCCIS | negative regulation of cell migration | 37/919 | 344/18723 | 6.66e-06 | 2.64e-04 | 37 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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