![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: FBXO7 |
Gene summary for FBXO7 |
![]() |
Gene information | Species | Human | Gene symbol | FBXO7 | Gene ID | 25793 |
Gene name | F-box protein 7 | |
Gene Alias | FBX | |
Cytomap | 22q12.3 | |
Gene Type | protein-coding | GO ID | GO:0000079 | UniProtAcc | Q9Y3I1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25793 | FBXO7 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.59e-05 | 4.91e-01 | -0.0811 |
25793 | FBXO7 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.22e-06 | 3.35e-01 | -0.1954 |
25793 | FBXO7 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.43e-08 | 4.83e-01 | -0.059 |
25793 | FBXO7 | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.08e-03 | 2.33e-01 | 0.0674 |
25793 | FBXO7 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.33e-12 | 4.99e-01 | 0.294 |
25793 | FBXO7 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.24e-02 | 8.03e-01 | 0.3487 |
25793 | FBXO7 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.95e-11 | 5.32e-01 | 0.3859 |
25793 | FBXO7 | A015-C-203 | Human | Colorectum | FAP | 1.40e-05 | -1.19e-01 | -0.1294 |
25793 | FBXO7 | A001-C-108 | Human | Colorectum | FAP | 2.98e-02 | -1.07e-01 | -0.0272 |
25793 | FBXO7 | A002-C-205 | Human | Colorectum | FAP | 6.28e-03 | -1.40e-01 | -0.1236 |
25793 | FBXO7 | A002-C-114 | Human | Colorectum | FAP | 8.55e-03 | -1.84e-01 | -0.1561 |
25793 | FBXO7 | A015-C-104 | Human | Colorectum | FAP | 2.30e-04 | -8.95e-02 | -0.1899 |
25793 | FBXO7 | A002-C-116 | Human | Colorectum | FAP | 6.96e-05 | -8.61e-02 | -0.0452 |
25793 | FBXO7 | F034 | Human | Colorectum | FAP | 1.35e-02 | -7.51e-02 | -0.0665 |
25793 | FBXO7 | LZE4T | Human | Esophagus | ESCC | 1.29e-18 | 3.11e-01 | 0.0811 |
25793 | FBXO7 | LZE5T | Human | Esophagus | ESCC | 2.51e-05 | 2.05e-01 | 0.0514 |
25793 | FBXO7 | LZE7T | Human | Esophagus | ESCC | 4.73e-10 | 7.54e-01 | 0.0667 |
25793 | FBXO7 | LZE8T | Human | Esophagus | ESCC | 5.66e-12 | 2.17e-01 | 0.067 |
25793 | FBXO7 | LZE22T | Human | Esophagus | ESCC | 3.46e-02 | 3.49e-01 | 0.068 |
25793 | FBXO7 | LZE24T | Human | Esophagus | ESCC | 1.29e-26 | 9.28e-01 | 0.0596 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190199114 | Skin | cSCC | negative regulation of mitotic cell cycle phase transition | 75/4864 | 179/18723 | 2.38e-06 | 3.84e-05 | 75 |
GO:007099729 | Skin | cSCC | neuron death | 133/4864 | 361/18723 | 2.91e-06 | 4.58e-05 | 133 |
GO:004593014 | Skin | cSCC | negative regulation of mitotic cell cycle | 93/4864 | 235/18723 | 3.14e-06 | 4.89e-05 | 93 |
GO:004578613 | Skin | cSCC | negative regulation of cell cycle | 140/4864 | 385/18723 | 3.64e-06 | 5.50e-05 | 140 |
GO:000008222 | Skin | cSCC | G1/S transition of mitotic cell cycle | 85/4864 | 214/18723 | 6.90e-06 | 9.60e-05 | 85 |
GO:004232626 | Skin | cSCC | negative regulation of phosphorylation | 137/4864 | 385/18723 | 1.63e-05 | 1.99e-04 | 137 |
GO:004484322 | Skin | cSCC | cell cycle G1/S phase transition | 92/4864 | 241/18723 | 1.95e-05 | 2.28e-04 | 92 |
GO:00108229 | Skin | cSCC | positive regulation of mitochondrion organization | 36/4864 | 74/18723 | 2.31e-05 | 2.66e-04 | 36 |
GO:000193326 | Skin | cSCC | negative regulation of protein phosphorylation | 123/4864 | 342/18723 | 2.48e-05 | 2.82e-04 | 123 |
GO:005134829 | Skin | cSCC | negative regulation of transferase activity | 100/4864 | 268/18723 | 2.60e-05 | 2.94e-04 | 100 |
GO:190198812 | Skin | cSCC | negative regulation of cell cycle phase transition | 94/4864 | 249/18723 | 2.65e-05 | 3.00e-04 | 94 |
GO:001094812 | Skin | cSCC | negative regulation of cell cycle process | 108/4864 | 294/18723 | 2.75e-05 | 3.09e-04 | 108 |
GO:00000795 | Skin | cSCC | regulation of cyclin-dependent protein serine/threonine kinase activity | 41/4864 | 94/18723 | 1.53e-04 | 1.35e-03 | 41 |
GO:190121426 | Skin | cSCC | regulation of neuron death | 112/4864 | 319/18723 | 1.71e-04 | 1.48e-03 | 112 |
GO:0036473111 | Skin | cSCC | cell death in response to oxidative stress | 41/4864 | 95/18723 | 2.02e-04 | 1.68e-03 | 41 |
GO:190402911 | Skin | cSCC | regulation of cyclin-dependent protein kinase activity | 42/4864 | 98/18723 | 2.05e-04 | 1.70e-03 | 42 |
GO:007190024 | Skin | cSCC | regulation of protein serine/threonine kinase activity | 123/4864 | 359/18723 | 2.70e-04 | 2.17e-03 | 123 |
GO:200004514 | Skin | cSCC | regulation of G1/S transition of mitotic cell cycle | 56/4864 | 142/18723 | 2.95e-04 | 2.35e-03 | 56 |
GO:190314615 | Skin | cSCC | regulation of autophagy of mitochondrion | 17/4864 | 33/18723 | 1.50e-03 | 9.36e-03 | 17 |
GO:190280614 | Skin | cSCC | regulation of cell cycle G1/S phase transition | 61/4864 | 168/18723 | 1.93e-03 | 1.16e-02 | 61 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FBXO7 | SNV | Missense_Mutation | c.1042N>T | p.Asp348Tyr | p.D348Y | Q9Y3I1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AR-A24T-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD | |
FBXO7 | SNV | Missense_Mutation | novel | c.1171N>C | p.Asp391His | p.D391H | Q9Y3I1 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-C8-A3M7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
FBXO7 | SNV | Missense_Mutation | c.997N>C | p.Val333Leu | p.V333L | Q9Y3I1 | protein_coding | tolerated(0.37) | benign(0.007) | TCGA-D8-A1XR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD | |
FBXO7 | insertion | Frame_Shift_Ins | novel | c.616_617insAAAATTT | p.Leu206GlnfsTer32 | p.L206Qfs*32 | Q9Y3I1 | protein_coding | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
FBXO7 | SNV | Missense_Mutation | c.823N>C | p.Lys275Gln | p.K275Q | Q9Y3I1 | protein_coding | tolerated(0.12) | possibly_damaging(0.795) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FBXO7 | SNV | Missense_Mutation | rs376214763 | c.652G>A | p.Glu218Lys | p.E218K | Q9Y3I1 | protein_coding | deleterious(0.01) | probably_damaging(0.985) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FBXO7 | SNV | Missense_Mutation | c.713N>T | p.Tyr238Phe | p.Y238F | Q9Y3I1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
FBXO7 | SNV | Missense_Mutation | c.848N>A | p.Ser283Tyr | p.S283Y | Q9Y3I1 | protein_coding | deleterious(0) | probably_damaging(0.914) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
FBXO7 | SNV | Missense_Mutation | rs376455464 | c.521N>T | p.Ser174Leu | p.S174L | Q9Y3I1 | protein_coding | deleterious(0) | benign(0.058) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
FBXO7 | SNV | Missense_Mutation | c.1118N>A | p.Arg373Lys | p.R373K | Q9Y3I1 | protein_coding | tolerated(0.07) | probably_damaging(0.999) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |