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Gene: AK3 |
Gene summary for AK3 |
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Gene information | Species | Human | Gene symbol | AK3 | Gene ID | 50808 |
Gene name | adenylate kinase 3 | |
Gene Alias | AK3L1 | |
Cytomap | 9p24.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q7Z4Y4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
50808 | AK3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.56e-10 | -4.96e-01 | 0.0155 |
50808 | AK3 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.84e-12 | 6.58e-01 | -0.1954 |
50808 | AK3 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 8.62e-11 | 9.83e-01 | 0.281 |
50808 | AK3 | A001-C-207 | Human | Colorectum | FAP | 9.64e-03 | -1.41e-01 | 0.1278 |
50808 | AK3 | A015-C-203 | Human | Colorectum | FAP | 5.10e-30 | 1.10e-03 | -0.1294 |
50808 | AK3 | A015-C-204 | Human | Colorectum | FAP | 1.59e-04 | -2.18e-01 | -0.0228 |
50808 | AK3 | A014-C-040 | Human | Colorectum | FAP | 7.34e-05 | -4.12e-01 | -0.1184 |
50808 | AK3 | A002-C-201 | Human | Colorectum | FAP | 6.66e-10 | -1.98e-01 | 0.0324 |
50808 | AK3 | A002-C-203 | Human | Colorectum | FAP | 3.24e-03 | -5.46e-02 | 0.2786 |
50808 | AK3 | A001-C-119 | Human | Colorectum | FAP | 2.55e-04 | -1.54e-01 | -0.1557 |
50808 | AK3 | A001-C-108 | Human | Colorectum | FAP | 1.02e-15 | -1.60e-01 | -0.0272 |
50808 | AK3 | A002-C-205 | Human | Colorectum | FAP | 1.20e-22 | -2.14e-01 | -0.1236 |
50808 | AK3 | A015-C-005 | Human | Colorectum | FAP | 2.74e-02 | -2.10e-01 | -0.0336 |
50808 | AK3 | A015-C-006 | Human | Colorectum | FAP | 4.14e-16 | -2.43e-01 | -0.0994 |
50808 | AK3 | A015-C-106 | Human | Colorectum | FAP | 8.21e-12 | -1.32e-03 | -0.0511 |
50808 | AK3 | A002-C-114 | Human | Colorectum | FAP | 3.65e-18 | -2.23e-01 | -0.1561 |
50808 | AK3 | A015-C-104 | Human | Colorectum | FAP | 6.02e-33 | -3.61e-03 | -0.1899 |
50808 | AK3 | A015-C-202 | Human | Colorectum | FAP | 2.06e-03 | 3.31e-01 | -0.0849 |
50808 | AK3 | A001-C-014 | Human | Colorectum | FAP | 1.12e-14 | -2.71e-01 | 0.0135 |
50808 | AK3 | A002-C-016 | Human | Colorectum | FAP | 2.89e-21 | -2.19e-01 | 0.0521 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000926710 | Prostate | BPH | cellular response to starvation | 52/3107 | 156/18723 | 2.24e-07 | 4.89e-06 | 52 |
GO:003166718 | Prostate | BPH | response to nutrient levels | 121/3107 | 474/18723 | 3.68e-07 | 7.70e-06 | 121 |
GO:00015039 | Prostate | BPH | ossification | 107/3107 | 408/18723 | 4.31e-07 | 8.83e-06 | 107 |
GO:000926610 | Prostate | BPH | response to temperature stimulus | 56/3107 | 178/18723 | 6.74e-07 | 1.30e-05 | 56 |
GO:000914117 | Prostate | BPH | nucleoside triphosphate metabolic process | 40/3107 | 112/18723 | 7.34e-07 | 1.39e-05 | 40 |
GO:000914210 | Prostate | BPH | nucleoside triphosphate biosynthetic process | 33/3107 | 85/18723 | 7.76e-07 | 1.45e-05 | 33 |
GO:001095017 | Prostate | BPH | positive regulation of endopeptidase activity | 56/3107 | 179/18723 | 8.24e-07 | 1.54e-05 | 56 |
GO:00342494 | Prostate | BPH | negative regulation of cellular amide metabolic process | 77/3107 | 273/18723 | 9.10e-07 | 1.67e-05 | 77 |
GO:000918516 | Prostate | BPH | ribonucleoside diphosphate metabolic process | 38/3107 | 106/18723 | 1.24e-06 | 2.17e-05 | 38 |
GO:000913215 | Prostate | BPH | nucleoside diphosphate metabolic process | 42/3107 | 124/18723 | 1.97e-06 | 3.27e-05 | 42 |
GO:004259410 | Prostate | BPH | response to starvation | 59/3107 | 197/18723 | 2.10e-06 | 3.45e-05 | 59 |
GO:004328016 | Prostate | BPH | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 43/3107 | 129/18723 | 2.41e-06 | 3.90e-05 | 43 |
GO:000915217 | Prostate | BPH | purine ribonucleotide biosynthetic process | 52/3107 | 169/18723 | 3.46e-06 | 5.42e-05 | 52 |
GO:00069848 | Prostate | BPH | ER-nucleus signaling pathway | 21/3107 | 46/18723 | 3.84e-06 | 5.88e-05 | 21 |
GO:000913517 | Prostate | BPH | purine nucleoside diphosphate metabolic process | 36/3107 | 103/18723 | 4.58e-06 | 6.81e-05 | 36 |
GO:000917917 | Prostate | BPH | purine ribonucleoside diphosphate metabolic process | 36/3107 | 103/18723 | 4.58e-06 | 6.81e-05 | 36 |
GO:00171484 | Prostate | BPH | negative regulation of translation | 68/3107 | 245/18723 | 7.01e-06 | 1.01e-04 | 68 |
GO:200105616 | Prostate | BPH | positive regulation of cysteine-type endopeptidase activity | 46/3107 | 148/18723 | 9.21e-06 | 1.29e-04 | 46 |
GO:000911717 | Prostate | BPH | nucleotide metabolic process | 118/3107 | 489/18723 | 9.68e-06 | 1.35e-04 | 118 |
GO:000926010 | Prostate | BPH | ribonucleotide biosynthetic process | 53/3107 | 182/18723 | 1.63e-05 | 2.05e-04 | 53 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012325 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa012405 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa0123212 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa0124012 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa01240 | Liver | Cirrhotic | Biosynthesis of cofactors | 66/2530 | 153/8465 | 3.11e-04 | 1.99e-03 | 1.23e-03 | 66 |
hsa01232 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
hsa012401 | Liver | Cirrhotic | Biosynthesis of cofactors | 66/2530 | 153/8465 | 3.11e-04 | 1.99e-03 | 1.23e-03 | 66 |
hsa012321 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
hsa012402 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa012322 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
hsa012403 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa012323 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
hsa012324 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
hsa012404 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
hsa0123211 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
hsa0124011 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
hsa0123221 | Oral cavity | LP | Nucleotide metabolism | 42/2418 | 85/8465 | 3.62e-05 | 2.36e-04 | 1.52e-04 | 42 |
hsa0124021 | Oral cavity | LP | Biosynthesis of cofactors | 57/2418 | 153/8465 | 1.17e-02 | 3.91e-02 | 2.52e-02 | 57 |
hsa0123231 | Oral cavity | LP | Nucleotide metabolism | 42/2418 | 85/8465 | 3.62e-05 | 2.36e-04 | 1.52e-04 | 42 |
hsa0124031 | Oral cavity | LP | Biosynthesis of cofactors | 57/2418 | 153/8465 | 1.17e-02 | 3.91e-02 | 2.52e-02 | 57 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AK3 | SNV | Missense_Mutation | novel | c.593G>A | p.Gly198Glu | p.G198E | Q9UIJ7 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD |
AK3 | SNV | Missense_Mutation | rs773321603 | c.53N>G | p.Ser18Trp | p.S18W | Q9UIJ7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EK-A2R8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
AK3 | SNV | Missense_Mutation | c.456N>G | p.Asp152Glu | p.D152E | Q9UIJ7 | protein_coding | deleterious(0) | probably_damaging(0.913) | TCGA-AA-3695-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
AK3 | SNV | Missense_Mutation | novel | c.359T>G | p.Val120Gly | p.V120G | Q9UIJ7 | protein_coding | deleterious(0) | possibly_damaging(0.878) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
AK3 | SNV | Missense_Mutation | c.88C>G | p.His30Asp | p.H30D | Q9UIJ7 | protein_coding | tolerated(0.78) | benign(0) | TCGA-D5-6535-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
AK3 | deletion | Frame_Shift_Del | c.7delN | p.Ala3ArgfsTer9 | p.A3Rfs*9 | Q9UIJ7 | protein_coding | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
AK3 | deletion | Frame_Shift_Del | c.7delG | p.Ala3ArgfsTer9 | p.A3Rfs*9 | Q9UIJ7 | protein_coding | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | |||
AK3 | SNV | Missense_Mutation | novel | c.115N>A | p.Gly39Arg | p.G39R | Q9UIJ7 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AK3 | SNV | Missense_Mutation | rs750035551 | c.370N>T | p.Arg124Cys | p.R124C | Q9UIJ7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
AK3 | SNV | Missense_Mutation | novel | c.436N>C | p.Lys146Gln | p.K146Q | Q9UIJ7 | protein_coding | tolerated(0.27) | benign(0.106) | TCGA-AJ-A3OL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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