Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact
Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: UBL5

Gene summary for UBL5

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

UBL5

Gene ID

59286

Gene nameubiquitin like 5
Gene AliasHUB1
Cytomap19p13.2
Gene Typeprotein-coding
GO ID

GO:0000375

UniProtAcc

A0A024R7B0


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
59286UBL5GSM4909286HumanBreastIDC2.99e-02-8.74e-020.1081
59286UBL5GSM4909287HumanBreastIDC6.61e-111.87e-010.2057
59286UBL5GSM4909288HumanBreastIDC8.60e-05-2.30e-010.0988
59286UBL5GSM4909290HumanBreastIDC1.13e-052.76e-010.2096
59286UBL5GSM4909291HumanBreastIDC1.45e-154.00e-010.1753
59286UBL5GSM4909294HumanBreastIDC5.13e-362.34e-010.2022
59286UBL5GSM4909296HumanBreastIDC7.67e-322.79e-010.1524
59286UBL5GSM4909297HumanBreastIDC5.47e-354.44e-020.1517
59286UBL5GSM4909298HumanBreastIDC7.30e-224.29e-010.1551
59286UBL5GSM4909301HumanBreastIDC9.51e-334.40e-010.1577
59286UBL5GSM4909302HumanBreastIDC2.46e-122.10e-010.1545
59286UBL5GSM4909303HumanBreastIDC7.44e-032.24e-010.0438
59286UBL5GSM4909304HumanBreastIDC1.72e-475.59e-010.1636
59286UBL5GSM4909306HumanBreastIDC1.27e-143.74e-010.1564
59286UBL5GSM4909309HumanBreastIDC1.63e-04-1.61e-020.0483
59286UBL5GSM4909311HumanBreastIDC9.56e-711.32e-010.1534
59286UBL5GSM4909312HumanBreastIDC3.41e-241.17e-010.1552
59286UBL5GSM4909313HumanBreastIDC4.38e-042.39e-020.0391
59286UBL5GSM4909315HumanBreastIDC2.76e-555.81e-010.21
59286UBL5GSM4909316HumanBreastIDC2.06e-457.13e-010.21
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
BreastThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.IDC: Invasive ductal carcinoma
DCIS: Ductal carcinoma in situ
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0006605113ThyroidPTCprotein targeting180/5968314/187236.81e-211.19e-18180
GO:1903829113ThyroidPTCpositive regulation of cellular protein localization162/5968276/187232.40e-203.52e-18162
GO:000683928ThyroidPTCmitochondrial transport150/5968254/187232.76e-193.34e-17150
GO:1904951113ThyroidPTCpositive regulation of establishment of protein localization175/5968319/187231.10e-171.12e-15175
GO:0051222113ThyroidPTCpositive regulation of protein transport163/5968303/187231.58e-151.16e-13163
GO:0070585112ThyroidPTCprotein localization to mitochondrion83/5968125/187232.15e-151.56e-1383
GO:0072655112ThyroidPTCestablishment of protein localization to mitochondrion80/5968120/187234.87e-153.30e-1380
GO:0006626111ThyroidPTCprotein targeting to mitochondrion67/5968100/187235.55e-132.74e-1167
GO:190321416ThyroidPTCregulation of protein targeting to mitochondrion33/596844/187235.20e-091.34e-0733
GO:190374718ThyroidPTCregulation of establishment of protein localization to mitochondrion36/596850/187236.68e-091.70e-0736
GO:190353310ThyroidPTCregulation of protein targeting51/596881/187238.40e-092.07e-0751
GO:19039558ThyroidPTCpositive regulation of protein targeting to mitochondrion24/596832/187236.76e-071.07e-0524
GO:190374910ThyroidPTCpositive regulation of establishment of protein localization to mitochondrion26/596836/187237.90e-071.22e-0526
GO:000037728ThyroidgoitersRNA splicing, via transesterification reactions with bulged adenosine as nucleophile26/497320/187234.75e-073.12e-0526
GO:000039828ThyroidgoitersmRNA splicing, via spliceosome26/497320/187234.75e-073.12e-0526
GO:000037528ThyroidgoitersRNA splicing, via transesterification reactions26/497324/187236.03e-073.78e-0526
GO:000838029ThyroidgoitersRNA splicing31/497434/187236.49e-073.95e-0531
GO:0006839112Thyroidgoitersmitochondrial transport22/497254/187231.26e-067.05e-0522
GO:000660529Thyroidgoitersprotein targeting19/497314/187237.74e-041.73e-0219
GO:007265527Thyroidgoitersestablishment of protein localization to mitochondrion10/497120/187231.36e-032.66e-0210
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
Page: 1 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
UBL5SNVMissense_Mutationnovelc.198G>Ap.Met66Ilep.M66IQ9BZL1protein_codingdeleterious(0.03)benign(0.01)TCGA-VS-A958-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
UBL5SNVMissense_Mutationc.61N>Ap.Asp21Asnp.D21NQ9BZL1protein_codingtolerated(0.16)benign(0.003)TCGA-AP-A051-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
Page: 1 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
Page: 1