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Gene: TH |
Gene summary for TH |
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Gene information | Species | Human | Gene symbol | TH | Gene ID | 7054 |
Gene name | tyrosine hydroxylase | |
Gene Alias | DYT14 | |
Cytomap | 11p15.5 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P07101 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7054 | TH | C04 | Human | Oral cavity | OSCC | 2.26e-15 | 7.94e-01 | 0.2633 |
7054 | TH | C21 | Human | Oral cavity | OSCC | 3.65e-07 | 1.94e-01 | 0.2678 |
7054 | TH | C30 | Human | Oral cavity | OSCC | 2.87e-17 | 6.63e-01 | 0.3055 |
7054 | TH | C51 | Human | Oral cavity | OSCC | 4.98e-04 | 2.56e-01 | 0.2674 |
7054 | TH | SYSMH5 | Human | Oral cavity | OSCC | 3.73e-03 | 1.34e-01 | 0.0647 |
7054 | TH | P4_cSCC | Human | Skin | cSCC | 3.76e-02 | 9.18e-02 | -0.00290000000000005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00009562 | Colorectum | FAP | nuclear-transcribed mRNA catabolic process | 33/2622 | 112/18723 | 1.69e-05 | 4.35e-04 | 33 |
GO:19023693 | Colorectum | FAP | negative regulation of RNA catabolic process | 25/2622 | 75/18723 | 1.74e-05 | 4.42e-04 | 25 |
GO:00444034 | Colorectum | FAP | biological process involved in symbiotic interaction | 66/2622 | 290/18723 | 3.47e-05 | 7.64e-04 | 66 |
GO:19013614 | Colorectum | FAP | organic cyclic compound catabolic process | 101/2622 | 495/18723 | 4.87e-05 | 9.93e-04 | 101 |
GO:00605622 | Colorectum | FAP | epithelial tube morphogenesis | 71/2622 | 325/18723 | 7.23e-05 | 1.33e-03 | 71 |
GO:00427523 | Colorectum | FAP | regulation of circadian rhythm | 33/2622 | 121/18723 | 9.26e-05 | 1.59e-03 | 33 |
GO:00351482 | Colorectum | FAP | tube formation | 38/2622 | 148/18723 | 1.17e-04 | 1.91e-03 | 38 |
GO:00434893 | Colorectum | FAP | RNA stabilization | 21/2622 | 65/18723 | 1.33e-04 | 2.13e-03 | 21 |
GO:00064034 | Colorectum | FAP | RNA localization | 47/2622 | 201/18723 | 2.27e-04 | 3.22e-03 | 47 |
GO:00514024 | Colorectum | FAP | neuron apoptotic process | 55/2622 | 246/18723 | 2.42e-04 | 3.37e-03 | 55 |
GO:00313453 | Colorectum | FAP | negative regulation of cell projection organization | 44/2622 | 186/18723 | 2.69e-04 | 3.64e-03 | 44 |
GO:00018413 | Colorectum | FAP | neural tube formation | 28/2622 | 102/18723 | 2.71e-04 | 3.64e-03 | 28 |
GO:00517014 | Colorectum | FAP | biological process involved in interaction with host | 47/2622 | 203/18723 | 2.89e-04 | 3.77e-03 | 47 |
GO:00457872 | Colorectum | FAP | positive regulation of cell cycle | 66/2622 | 313/18723 | 3.66e-04 | 4.63e-03 | 66 |
GO:00140202 | Colorectum | FAP | primary neural tube formation | 26/2622 | 94/18723 | 3.87e-04 | 4.75e-03 | 26 |
GO:00511684 | Colorectum | FAP | nuclear export | 37/2622 | 154/18723 | 5.81e-04 | 6.46e-03 | 37 |
GO:00512364 | Colorectum | FAP | establishment of RNA localization | 39/2622 | 166/18723 | 6.71e-04 | 7.28e-03 | 39 |
GO:19023733 | Colorectum | FAP | negative regulation of mRNA catabolic process | 19/2622 | 63/18723 | 7.22e-04 | 7.72e-03 | 19 |
GO:00219152 | Colorectum | FAP | neural tube development | 36/2622 | 152/18723 | 9.05e-04 | 9.17e-03 | 36 |
GO:00506574 | Colorectum | FAP | nucleic acid transport | 38/2622 | 163/18723 | 9.12e-04 | 9.19e-03 | 38 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501230 | Oral cavity | OSCC | Parkinson disease | 188/3704 | 266/8465 | 1.82e-19 | 1.52e-17 | 7.75e-18 | 188 |
hsa05012113 | Oral cavity | OSCC | Parkinson disease | 188/3704 | 266/8465 | 1.82e-19 | 1.52e-17 | 7.75e-18 | 188 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TH | SNV | Missense_Mutation | c.58N>C | p.Glu20Gln | p.E20Q | P07101 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.998) | TCGA-E2-A1LS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cyclophosphamide | SD | |
TH | SNV | Missense_Mutation | novel | c.307N>A | p.Ala103Thr | p.A103T | P07101 | protein_coding | tolerated(0.31) | benign(0.055) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TH | SNV | Missense_Mutation | rs760640869 | c.374N>T | p.Ser125Leu | p.S125L | P07101 | protein_coding | deleterious(0.01) | benign(0.058) | TCGA-EA-A3QD-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
TH | SNV | Missense_Mutation | c.235N>A | p.Glu79Lys | p.E79K | P07101 | protein_coding | deleterious(0.04) | probably_damaging(0.957) | TCGA-MY-A5BD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TH | SNV | Missense_Mutation | rs372409517 | c.677N>T | p.Ser226Leu | p.S226L | P07101 | protein_coding | deleterious(0.01) | possibly_damaging(0.661) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TH | SNV | Missense_Mutation | novel | c.1201N>C | p.Tyr401His | p.Y401H | P07101 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TH | SNV | Missense_Mutation | novel | c.944N>A | p.Gly315Asp | p.G315D | P07101 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
TH | SNV | Missense_Mutation | rs757607038 | c.806C>T | p.Thr269Met | p.T269M | P07101 | protein_coding | deleterious(0.04) | possibly_damaging(0.904) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TH | SNV | Missense_Mutation | c.721N>A | p.Ala241Thr | p.A241T | P07101 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TH | SNV | Missense_Mutation | rs200751977 | c.1492G>A | p.Asp498Asn | p.D498N | P07101 | protein_coding | deleterious(0.02) | benign(0.077) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7054 | TH | ENZYME, DRUGGABLE GENOME | L-Phenylalanine | PHENYLALANINE | ||
7054 | TH | ENZYME, DRUGGABLE GENOME | methylphenidate | METHYLPHENIDATE | 26810137 | |
7054 | TH | ENZYME, DRUGGABLE GENOME | metyrosine | METYROSINE | ||
7054 | TH | ENZYME, DRUGGABLE GENOME | EPO | EPOETIN ALFA | 16368081 | |
7054 | TH | ENZYME, DRUGGABLE GENOME | TETRAHYDROBIOPTERIN | SAPROPTERIN | ||
7054 | TH | ENZYME, DRUGGABLE GENOME | SERTRALINE HYDROCHLORIDE | 8629887 | ||
7054 | TH | ENZYME, DRUGGABLE GENOME | DEHYDROEPIANDROSTERONE | PRASTERONE | 8704732 | |
7054 | TH | ENZYME, DRUGGABLE GENOME | inhibitor | CHEMBL1200862 | METYROSINE | |
7054 | TH | ENZYME, DRUGGABLE GENOME | IFN | 8724983 | ||
7054 | TH | ENZYME, DRUGGABLE GENOME | DOXYCYCLINE | DOXYCYCLINE | 15585109 |
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