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Gene: SSB |
Gene summary for SSB |
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Gene information | Species | Human | Gene symbol | SSB | Gene ID | 6741 |
Gene name | small RNA binding exonuclease protection factor La | |
Gene Alias | LARP3 | |
Cytomap | 2q31.1 | |
Gene Type | protein-coding | GO ID | GO:0000956 | UniProtAcc | P05455 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6741 | SSB | CA_HPV_1 | Human | Cervix | CC | 1.95e-06 | -7.50e-02 | 0.0264 |
6741 | SSB | CCI_1 | Human | Cervix | CC | 2.89e-07 | -5.70e-01 | 0.528 |
6741 | SSB | CCI_2 | Human | Cervix | CC | 1.35e-03 | -4.83e-01 | 0.5249 |
6741 | SSB | CCI_3 | Human | Cervix | CC | 2.35e-07 | -5.14e-01 | 0.516 |
6741 | SSB | CCII_1 | Human | Cervix | CC | 3.96e-16 | -5.94e-01 | 0.3249 |
6741 | SSB | sample3 | Human | Cervix | CC | 2.70e-03 | -2.60e-01 | 0.1387 |
6741 | SSB | L1 | Human | Cervix | CC | 1.82e-09 | -3.65e-01 | 0.0802 |
6741 | SSB | T1 | Human | Cervix | CC | 4.04e-05 | -3.02e-01 | 0.0918 |
6741 | SSB | T3 | Human | Cervix | CC | 1.46e-02 | -2.63e-01 | 0.1389 |
6741 | SSB | AEH-subject1 | Human | Endometrium | AEH | 2.29e-18 | -5.09e-01 | -0.3059 |
6741 | SSB | AEH-subject2 | Human | Endometrium | AEH | 1.32e-21 | -5.38e-01 | -0.2525 |
6741 | SSB | AEH-subject3 | Human | Endometrium | AEH | 6.38e-16 | -3.80e-01 | -0.2576 |
6741 | SSB | AEH-subject4 | Human | Endometrium | AEH | 8.29e-06 | -3.56e-01 | -0.2657 |
6741 | SSB | AEH-subject5 | Human | Endometrium | AEH | 3.25e-12 | -4.34e-01 | -0.2953 |
6741 | SSB | EEC-subject1 | Human | Endometrium | EEC | 4.96e-16 | -4.13e-01 | -0.2682 |
6741 | SSB | EEC-subject2 | Human | Endometrium | EEC | 3.66e-24 | -5.05e-01 | -0.2607 |
6741 | SSB | EEC-subject3 | Human | Endometrium | EEC | 4.89e-53 | -5.03e-01 | -0.2525 |
6741 | SSB | EEC-subject4 | Human | Endometrium | EEC | 7.89e-10 | -2.88e-01 | -0.2571 |
6741 | SSB | EEC-subject5 | Human | Endometrium | EEC | 2.53e-08 | -2.98e-01 | -0.249 |
6741 | SSB | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.93e-33 | -2.89e-01 | -0.1869 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006401112 | Thyroid | PTC | RNA catabolic process | 163/5968 | 278/18723 | 2.13e-20 | 3.27e-18 | 163 |
GO:0006402112 | Thyroid | PTC | mRNA catabolic process | 139/5968 | 232/18723 | 9.59e-19 | 1.12e-16 | 139 |
GO:0051168112 | Thyroid | PTC | nuclear export | 102/5968 | 154/18723 | 1.78e-18 | 2.01e-16 | 102 |
GO:0034655112 | Thyroid | PTC | nucleobase-containing compound catabolic process | 211/5968 | 407/18723 | 2.72e-17 | 2.52e-15 | 211 |
GO:0000956111 | Thyroid | PTC | nuclear-transcribed mRNA catabolic process | 78/5968 | 112/18723 | 2.37e-16 | 1.94e-14 | 78 |
GO:00346608 | Thyroid | PTC | ncRNA metabolic process | 239/5968 | 485/18723 | 5.54e-16 | 4.26e-14 | 239 |
GO:0046700111 | Thyroid | PTC | heterocycle catabolic process | 221/5968 | 445/18723 | 2.43e-15 | 1.72e-13 | 221 |
GO:0044270111 | Thyroid | PTC | cellular nitrogen compound catabolic process | 223/5968 | 451/18723 | 3.34e-15 | 2.31e-13 | 223 |
GO:0051236110 | Thyroid | PTC | establishment of RNA localization | 100/5968 | 166/18723 | 4.26e-14 | 2.58e-12 | 100 |
GO:0019439111 | Thyroid | PTC | aromatic compound catabolic process | 225/5968 | 467/18723 | 8.51e-14 | 4.71e-12 | 225 |
GO:0050657110 | Thyroid | PTC | nucleic acid transport | 98/5968 | 163/18723 | 9.08e-14 | 4.90e-12 | 98 |
GO:0050658110 | Thyroid | PTC | RNA transport | 98/5968 | 163/18723 | 9.08e-14 | 4.90e-12 | 98 |
GO:0019080110 | Thyroid | PTC | viral gene expression | 65/5968 | 94/18723 | 1.25e-13 | 6.69e-12 | 65 |
GO:1901361111 | Thyroid | PTC | organic cyclic compound catabolic process | 231/5968 | 495/18723 | 2.55e-12 | 1.12e-10 | 231 |
GO:0015931110 | Thyroid | PTC | nucleobase-containing compound transport | 120/5968 | 222/18723 | 5.45e-12 | 2.35e-10 | 120 |
GO:003304419 | Thyroid | PTC | regulation of chromosome organization | 102/5968 | 187/18723 | 1.04e-10 | 3.58e-09 | 102 |
GO:00311235 | Thyroid | PTC | RNA 3'-end processing | 65/5968 | 116/18723 | 6.24e-08 | 1.30e-06 | 65 |
GO:00711667 | Thyroid | PTC | ribonucleoprotein complex localization | 47/5968 | 77/18723 | 1.28e-07 | 2.48e-06 | 47 |
GO:00315037 | Thyroid | PTC | protein-containing complex localization | 107/5968 | 220/18723 | 1.47e-07 | 2.82e-06 | 107 |
GO:00064058 | Thyroid | PTC | RNA export from nucleus | 50/5968 | 84/18723 | 1.59e-07 | 3.03e-06 | 50 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SSB | SNV | Missense_Mutation | c.925N>A | p.Glu309Lys | p.E309K | P05455 | protein_coding | tolerated(0.07) | benign(0.106) | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SSB | SNV | Missense_Mutation | c.638N>A | p.Ala213Glu | p.A213E | P05455 | protein_coding | tolerated(1) | benign(0) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SSB | deletion | Frame_Shift_Del | novel | c.54delN | p.His19IlefsTer18 | p.H19Ifs*18 | P05455 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
SSB | SNV | Missense_Mutation | rs201142063 | c.676C>G | p.Leu226Val | p.L226V | P05455 | protein_coding | tolerated(0.09) | benign(0.017) | TCGA-C5-A902-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
SSB | SNV | Missense_Mutation | c.1048N>C | p.Ser350Pro | p.S350P | P05455 | protein_coding | tolerated(0.29) | benign(0.003) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
SSB | SNV | Missense_Mutation | novel | c.787N>T | p.Asp263Tyr | p.D263Y | P05455 | protein_coding | deleterious(0) | probably_damaging(0.916) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
SSB | SNV | Missense_Mutation | c.290N>C | p.Leu97Pro | p.L97P | P05455 | protein_coding | deleterious(0) | possibly_damaging(0.896) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | |
SSB | SNV | Missense_Mutation | c.1039N>A | p.Gln347Lys | p.Q347K | P05455 | protein_coding | tolerated(0.37) | benign(0.007) | TCGA-AG-3882-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SSB | SNV | Missense_Mutation | novel | c.452N>C | p.Lys151Thr | p.K151T | P05455 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SSB | SNV | Missense_Mutation | c.587N>T | p.Arg196Ile | p.R196I | P05455 | protein_coding | deleterious(0) | possibly_damaging(0.572) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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