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Gene: PBX1 |
Gene summary for PBX1 |
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Gene information | Species | Human | Gene symbol | PBX1 | Gene ID | 5087 |
Gene name | PBX homeobox 1 | |
Gene Alias | CAKUHED | |
Cytomap | 1q23.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A8K5V0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5087 | PBX1 | GSM4909281 | Human | Breast | IDC | 2.40e-04 | 2.61e-01 | 0.21 |
5087 | PBX1 | GSM4909285 | Human | Breast | IDC | 1.64e-04 | 1.89e-01 | 0.21 |
5087 | PBX1 | GSM4909286 | Human | Breast | IDC | 3.80e-05 | 2.45e-01 | 0.1081 |
5087 | PBX1 | GSM4909290 | Human | Breast | IDC | 2.00e-06 | 3.54e-01 | 0.2096 |
5087 | PBX1 | GSM4909291 | Human | Breast | IDC | 7.85e-27 | 7.88e-01 | 0.1753 |
5087 | PBX1 | GSM4909293 | Human | Breast | IDC | 1.41e-63 | 1.01e+00 | 0.1581 |
5087 | PBX1 | GSM4909297 | Human | Breast | IDC | 3.19e-10 | 3.07e-01 | 0.1517 |
5087 | PBX1 | GSM4909298 | Human | Breast | IDC | 1.15e-60 | 9.19e-01 | 0.1551 |
5087 | PBX1 | GSM4909301 | Human | Breast | IDC | 4.04e-17 | 5.74e-01 | 0.1577 |
5087 | PBX1 | GSM4909302 | Human | Breast | IDC | 1.81e-04 | 3.03e-01 | 0.1545 |
5087 | PBX1 | GSM4909303 | Human | Breast | IDC | 1.81e-03 | 4.42e-01 | 0.0438 |
5087 | PBX1 | GSM4909305 | Human | Breast | IDC | 1.32e-02 | 2.47e-01 | 0.0436 |
5087 | PBX1 | GSM4909306 | Human | Breast | IDC | 2.26e-16 | 5.99e-01 | 0.1564 |
5087 | PBX1 | GSM4909307 | Human | Breast | IDC | 1.76e-38 | 8.53e-01 | 0.1569 |
5087 | PBX1 | GSM4909308 | Human | Breast | IDC | 2.34e-63 | 9.63e-01 | 0.158 |
5087 | PBX1 | GSM4909309 | Human | Breast | IDC | 3.60e-06 | 3.63e-01 | 0.0483 |
5087 | PBX1 | GSM4909311 | Human | Breast | IDC | 7.25e-14 | 3.06e-02 | 0.1534 |
5087 | PBX1 | GSM4909312 | Human | Breast | IDC | 8.46e-43 | 8.14e-01 | 0.1552 |
5087 | PBX1 | GSM4909313 | Human | Breast | IDC | 1.84e-19 | 6.51e-01 | 0.0391 |
5087 | PBX1 | GSM4909317 | Human | Breast | IDC | 2.09e-45 | 9.58e-01 | 0.1355 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00721635 | Thyroid | HT | mesonephric epithelium development | 14/1272 | 92/18723 | 3.57e-03 | 2.73e-02 | 14 |
GO:00721645 | Thyroid | HT | mesonephric tubule development | 14/1272 | 92/18723 | 3.57e-03 | 2.73e-02 | 14 |
GO:000165516 | Thyroid | HT | urogenital system development | 36/1272 | 338/18723 | 4.99e-03 | 3.36e-02 | 36 |
GO:00018234 | Thyroid | HT | mesonephros development | 14/1272 | 96/18723 | 5.28e-03 | 3.50e-02 | 14 |
GO:000734618 | Thyroid | HT | regulation of mitotic cell cycle | 45/1272 | 457/18723 | 7.86e-03 | 4.61e-02 | 45 |
GO:00720806 | Thyroid | HT | nephron tubule development | 13/1272 | 91/18723 | 8.36e-03 | 4.79e-02 | 13 |
GO:000734619 | Thyroid | PTC | regulation of mitotic cell cycle | 212/5968 | 457/18723 | 4.03e-11 | 1.44e-09 | 212 |
GO:004477218 | Thyroid | PTC | mitotic cell cycle phase transition | 196/5968 | 424/18723 | 3.17e-10 | 1.02e-08 | 196 |
GO:0048732113 | Thyroid | PTC | gland development | 193/5968 | 436/18723 | 2.88e-08 | 6.42e-07 | 193 |
GO:004578718 | Thyroid | PTC | positive regulation of cell cycle | 144/5968 | 313/18723 | 9.93e-08 | 1.99e-06 | 144 |
GO:19019908 | Thyroid | PTC | regulation of mitotic cell cycle phase transition | 138/5968 | 299/18723 | 1.44e-07 | 2.78e-06 | 138 |
GO:004593119 | Thyroid | PTC | positive regulation of mitotic cell cycle | 65/5968 | 121/18723 | 5.08e-07 | 8.26e-06 | 65 |
GO:000182215 | Thyroid | PTC | kidney development | 133/5968 | 293/18723 | 7.57e-07 | 1.18e-05 | 133 |
GO:0001503110 | Thyroid | PTC | ossification | 176/5968 | 408/18723 | 9.26e-07 | 1.40e-05 | 176 |
GO:000165517 | Thyroid | PTC | urogenital system development | 149/5968 | 338/18723 | 1.41e-06 | 2.01e-05 | 149 |
GO:007200114 | Thyroid | PTC | renal system development | 135/5968 | 302/18723 | 1.76e-06 | 2.43e-05 | 135 |
GO:19019878 | Thyroid | PTC | regulation of cell cycle phase transition | 167/5968 | 390/18723 | 2.97e-06 | 3.87e-05 | 167 |
GO:006056219 | Thyroid | PTC | epithelial tube morphogenesis | 141/5968 | 325/18723 | 7.52e-06 | 8.73e-05 | 141 |
GO:009006816 | Thyroid | PTC | positive regulation of cell cycle process | 103/5968 | 236/18723 | 9.03e-05 | 7.50e-04 | 103 |
GO:00000866 | Thyroid | PTC | G2/M transition of mitotic cell cycle | 62/5968 | 137/18723 | 6.89e-04 | 4.32e-03 | 62 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05202 | Colorectum | FAP | Transcriptional misregulation in cancer | 45/1404 | 193/8465 | 9.19e-03 | 3.33e-02 | 2.03e-02 | 45 |
hsa052021 | Colorectum | FAP | Transcriptional misregulation in cancer | 45/1404 | 193/8465 | 9.19e-03 | 3.33e-02 | 2.03e-02 | 45 |
hsa052028 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa0520213 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa052026 | Lung | IAC | Transcriptional misregulation in cancer | 40/1053 | 193/8465 | 6.90e-04 | 5.90e-03 | 3.92e-03 | 40 |
hsa0520211 | Lung | IAC | Transcriptional misregulation in cancer | 40/1053 | 193/8465 | 6.90e-04 | 5.90e-03 | 3.92e-03 | 40 |
hsa052022 | Lung | AIS | Transcriptional misregulation in cancer | 39/961 | 193/8465 | 2.15e-04 | 2.41e-03 | 1.54e-03 | 39 |
hsa052023 | Lung | AIS | Transcriptional misregulation in cancer | 39/961 | 193/8465 | 2.15e-04 | 2.41e-03 | 1.54e-03 | 39 |
hsa052024 | Lung | MIAC | Transcriptional misregulation in cancer | 22/507 | 193/8465 | 2.64e-03 | 2.26e-02 | 1.64e-02 | 22 |
hsa052025 | Lung | MIAC | Transcriptional misregulation in cancer | 22/507 | 193/8465 | 2.64e-03 | 2.26e-02 | 1.64e-02 | 22 |
hsa052027 | Prostate | BPH | Transcriptional misregulation in cancer | 53/1718 | 193/8465 | 9.56e-03 | 2.92e-02 | 1.81e-02 | 53 |
hsa0520212 | Prostate | BPH | Transcriptional misregulation in cancer | 53/1718 | 193/8465 | 9.56e-03 | 2.92e-02 | 1.81e-02 | 53 |
hsa0520221 | Prostate | Tumor | Transcriptional misregulation in cancer | 59/1791 | 193/8465 | 1.22e-03 | 5.26e-03 | 3.26e-03 | 59 |
hsa0520231 | Prostate | Tumor | Transcriptional misregulation in cancer | 59/1791 | 193/8465 | 1.22e-03 | 5.26e-03 | 3.26e-03 | 59 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PBX1 | SNV | Missense_Mutation | c.1273N>A | p.His425Asn | p.H425N | P40424 | protein_coding | tolerated(0.27) | benign(0.005) | TCGA-A2-A0YH-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
PBX1 | SNV | Missense_Mutation | c.772N>T | p.Asn258Tyr | p.N258Y | P40424 | protein_coding | deleterious(0.01) | probably_damaging(0.916) | TCGA-AO-A03O-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | SD | |
PBX1 | SNV | Missense_Mutation | novel | c.446N>T | p.Asp149Val | p.D149V | P40424 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-C8-A8HP-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
PBX1 | SNV | Missense_Mutation | novel | c.704N>A | p.Arg235Gln | p.R235Q | P40424 | protein_coding | deleterious(0) | probably_damaging(0.951) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PBX1 | SNV | Missense_Mutation | novel | c.199G>T | p.Ala67Ser | p.A67S | P40424 | protein_coding | tolerated(0.15) | benign(0.091) | TCGA-EK-A2R9-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PBX1 | SNV | Missense_Mutation | c.361N>C | p.Glu121Gln | p.E121Q | P40424 | protein_coding | tolerated(0.08) | possibly_damaging(0.714) | TCGA-IR-A3LI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
PBX1 | SNV | Missense_Mutation | rs541105414 | c.1165G>A | p.Ala389Thr | p.A389T | P40424 | protein_coding | tolerated(0.53) | benign(0) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PBX1 | SNV | Missense_Mutation | rs201029742 | c.1160N>T | p.Gly387Val | p.G387V | P40424 | protein_coding | deleterious(0.03) | benign(0.003) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PBX1 | SNV | Missense_Mutation | c.614A>G | p.His205Arg | p.H205R | P40424 | protein_coding | tolerated(0.14) | benign(0.225) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | |
PBX1 | SNV | Missense_Mutation | c.868C>T | p.Arg290Trp | p.R290W | P40424 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-D5-6531-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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