Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/NUDT1_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/NUDT1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/NUDT1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/NUDT1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/NUDT1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/NUDT1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:009050111 | Oral cavity | LP | RNA phosphodiester bond hydrolysis | 63/4623 | 152/18723 | 3.88e-06 | 8.13e-05 | 63 |
GO:005105213 | Oral cavity | LP | regulation of DNA metabolic process | 125/4623 | 359/18723 | 9.43e-06 | 1.75e-04 | 125 |
GO:0031668110 | Oral cavity | LP | cellular response to extracellular stimulus | 91/4623 | 246/18723 | 1.07e-05 | 1.94e-04 | 91 |
GO:000911611 | Oral cavity | LP | nucleoside metabolic process | 31/4623 | 62/18723 | 1.46e-05 | 2.57e-04 | 31 |
GO:001819614 | Oral cavity | LP | peptidyl-asparagine modification | 16/4623 | 24/18723 | 1.68e-05 | 2.92e-04 | 16 |
GO:200102018 | Oral cavity | LP | regulation of response to DNA damage stimulus | 82/4623 | 219/18723 | 1.71e-05 | 2.97e-04 | 82 |
GO:001969211 | Oral cavity | LP | deoxyribose phosphate metabolic process | 23/4623 | 42/18723 | 2.85e-05 | 4.51e-04 | 23 |
GO:000939411 | Oral cavity | LP | 2'-deoxyribonucleotide metabolic process | 22/4623 | 40/18723 | 3.88e-05 | 5.71e-04 | 22 |
GO:001827914 | Oral cavity | LP | protein N-linked glycosylation via asparagine | 15/4623 | 23/18723 | 4.61e-05 | 6.51e-04 | 15 |
GO:004668617 | Oral cavity | LP | response to cadmium ion | 32/4623 | 68/18723 | 5.05e-05 | 7.07e-04 | 32 |
GO:000675319 | Oral cavity | LP | nucleoside phosphate metabolic process | 161/4623 | 497/18723 | 5.31e-05 | 7.39e-04 | 161 |
GO:0009117110 | Oral cavity | LP | nucleotide metabolic process | 158/4623 | 489/18723 | 7.17e-05 | 9.49e-04 | 158 |
GO:000926211 | Oral cavity | LP | deoxyribonucleotide metabolic process | 23/4623 | 44/18723 | 7.56e-05 | 9.87e-04 | 23 |
GO:00903051 | Oral cavity | LP | nucleic acid phosphodiester bond hydrolysis | 92/4623 | 261/18723 | 8.07e-05 | 1.04e-03 | 92 |
GO:000920011 | Oral cavity | LP | deoxyribonucleoside triphosphate metabolic process | 12/4623 | 17/18723 | 8.70e-05 | 1.10e-03 | 12 |
GO:0010038110 | Oral cavity | LP | response to metal ion | 124/4623 | 373/18723 | 1.09e-04 | 1.31e-03 | 124 |
GO:00160741 | Oral cavity | LP | sno(s)RNA metabolic process | 11/4623 | 16/18723 | 2.52e-04 | 2.63e-03 | 11 |
GO:0019693110 | Oral cavity | LP | ribose phosphate metabolic process | 128/4623 | 396/18723 | 3.26e-04 | 3.28e-03 | 128 |
GO:0072521110 | Oral cavity | LP | purine-containing compound metabolic process | 130/4623 | 416/18723 | 1.30e-03 | 1.05e-02 | 130 |
GO:00422781 | Oral cavity | LP | purine nucleoside metabolic process | 14/4623 | 26/18723 | 1.33e-03 | 1.07e-02 | 14 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NUDT1 | SNV | Missense_Mutation | rs374666803 | c.205N>A | p.Glu69Lys | p.E69K | P36639 | protein_coding | tolerated(0.2) | possibly_damaging(0.847) | TCGA-AC-A2B8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | chemo | PD |
NUDT1 | SNV | Missense_Mutation | rs746490760 | c.533N>T | p.Thr178Met | p.T178M | P36639 | protein_coding | tolerated(0.08) | benign(0.188) | TCGA-C8-A12V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NUDT1 | insertion | Nonsense_Mutation | novel | c.483_484insCCTGCTCTGCGCCCACCCTAAAATGAGAAACACGGTCATGAGGATGAAATA | p.Lys161_Phe162insProAlaLeuArgProProTerAsnGluLysHisGlyHisGluAspGluIle | p.K161_F162insPALRPP*NEKHGHEDEI | P36639 | protein_coding | | | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
NUDT1 | SNV | Missense_Mutation | | c.190N>C | p.Glu64Gln | p.E64Q | P36639 | protein_coding | tolerated(0.43) | benign(0.255) | TCGA-C5-A1M6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
NUDT1 | SNV | Missense_Mutation | rs747651511 | c.373C>T | p.Arg125Cys | p.R125C | P36639 | protein_coding | tolerated(0.05) | benign(0.073) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
NUDT1 | SNV | Missense_Mutation | novel | c.421N>T | p.Pro141Ser | p.P141S | P36639 | protein_coding | deleterious(0.05) | possibly_damaging(0.834) | TCGA-E6-A1M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
NUDT1 | SNV | Missense_Mutation | novel | c.466N>G | p.Phe156Val | p.F156V | P36639 | protein_coding | deleterious(0) | benign(0.436) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NUDT1 | SNV | Missense_Mutation | novel | c.124N>A | p.Leu42Ile | p.L42I | P36639 | protein_coding | deleterious(0) | possibly_damaging(0.787) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
NUDT1 | SNV | Missense_Mutation | novel | c.291N>A | p.Phe97Leu | p.F97L | P36639 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-QF-A5YS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
NUDT1 | SNV | Missense_Mutation | rs115556911 | c.367N>A | p.Glu123Lys | p.E123K | P36639 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-44-6779-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | taxol | PD |