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Gene: LOX |
Gene summary for LOX |
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Gene information | Species | Human | Gene symbol | LOX | Gene ID | 4015 |
Gene name | lysyl oxidase | |
Gene Alias | AAT10 | |
Cytomap | 5q23.1 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | B7ZAJ4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4015 | LOX | P4T-E | Human | Esophagus | ESCC | 3.52e-03 | 3.03e-01 | 0.1323 |
4015 | LOX | P8T-E | Human | Esophagus | ESCC | 7.98e-04 | 2.02e-01 | 0.0889 |
4015 | LOX | P16T-E | Human | Esophagus | ESCC | 2.51e-10 | 3.41e-01 | 0.1153 |
4015 | LOX | P17T-E | Human | Esophagus | ESCC | 1.22e-04 | 5.42e-01 | 0.1278 |
4015 | LOX | P23T-E | Human | Esophagus | ESCC | 8.95e-05 | 2.66e-01 | 0.108 |
4015 | LOX | P32T-E | Human | Esophagus | ESCC | 7.80e-22 | 9.89e-01 | 0.1666 |
4015 | LOX | P37T-E | Human | Esophagus | ESCC | 9.32e-18 | 6.36e-01 | 0.1371 |
4015 | LOX | P42T-E | Human | Esophagus | ESCC | 9.84e-07 | 3.99e-01 | 0.1175 |
4015 | LOX | P44T-E | Human | Esophagus | ESCC | 2.72e-04 | 6.69e-01 | 0.1096 |
4015 | LOX | P52T-E | Human | Esophagus | ESCC | 1.68e-10 | 5.54e-01 | 0.1555 |
4015 | LOX | P61T-E | Human | Esophagus | ESCC | 3.95e-07 | 2.81e-01 | 0.099 |
4015 | LOX | P62T-E | Human | Esophagus | ESCC | 1.12e-04 | 2.69e-01 | 0.1302 |
4015 | LOX | P74T-E | Human | Esophagus | ESCC | 1.39e-02 | 1.59e-01 | 0.1479 |
4015 | LOX | P76T-E | Human | Esophagus | ESCC | 1.70e-17 | 7.18e-01 | 0.1207 |
4015 | LOX | P89T-E | Human | Esophagus | ESCC | 1.46e-19 | 1.93e+00 | 0.1752 |
4015 | LOX | P91T-E | Human | Esophagus | ESCC | 1.63e-05 | 1.14e+00 | 0.1828 |
4015 | LOX | P130T-E | Human | Esophagus | ESCC | 2.01e-15 | 5.56e-01 | 0.1676 |
4015 | LOX | C21 | Human | Oral cavity | OSCC | 1.02e-16 | 8.01e-01 | 0.2678 |
4015 | LOX | C30 | Human | Oral cavity | OSCC | 8.45e-06 | 6.01e-01 | 0.3055 |
4015 | LOX | C43 | Human | Oral cavity | OSCC | 1.19e-30 | 5.57e-01 | 0.1704 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003021612 | Prostate | Tumor | keratinocyte differentiation | 41/3246 | 139/18723 | 2.73e-04 | 2.24e-03 | 41 |
GO:004568213 | Prostate | Tumor | regulation of epidermis development | 23/3246 | 65/18723 | 3.63e-04 | 2.84e-03 | 23 |
GO:004578611 | Prostate | Tumor | negative regulation of cell cycle | 93/3246 | 385/18723 | 3.79e-04 | 2.95e-03 | 93 |
GO:004001313 | Prostate | Tumor | negative regulation of locomotion | 94/3246 | 391/18723 | 4.20e-04 | 3.21e-03 | 94 |
GO:004560413 | Prostate | Tumor | regulation of epidermal cell differentiation | 21/3246 | 58/18723 | 4.52e-04 | 3.42e-03 | 21 |
GO:003033613 | Prostate | Tumor | negative regulation of cell migration | 84/3246 | 344/18723 | 4.95e-04 | 3.66e-03 | 84 |
GO:000181914 | Prostate | Tumor | positive regulation of cytokine production | 109/3246 | 467/18723 | 4.98e-04 | 3.67e-03 | 109 |
GO:000963627 | Thyroid | HT | response to toxic substance | 50/1272 | 262/18723 | 2.25e-11 | 3.75e-09 | 50 |
GO:199074827 | Thyroid | HT | cellular detoxification | 31/1272 | 116/18723 | 2.29e-11 | 3.75e-09 | 31 |
GO:009875420 | Thyroid | HT | detoxification | 36/1272 | 152/18723 | 2.63e-11 | 4.07e-09 | 36 |
GO:009723727 | Thyroid | HT | cellular response to toxic substance | 32/1272 | 124/18723 | 3.00e-11 | 4.51e-09 | 32 |
GO:009886926 | Thyroid | HT | cellular oxidant detoxification | 26/1272 | 101/18723 | 2.23e-09 | 2.26e-07 | 26 |
GO:001003830 | Thyroid | HT | response to metal ion | 50/1272 | 373/18723 | 3.12e-06 | 1.08e-04 | 50 |
GO:00507297 | Thyroid | HT | positive regulation of inflammatory response | 26/1272 | 142/18723 | 3.14e-06 | 1.08e-04 | 26 |
GO:00321039 | Thyroid | HT | positive regulation of response to external stimulus | 55/1272 | 427/18723 | 3.50e-06 | 1.16e-04 | 55 |
GO:00313497 | Thyroid | HT | positive regulation of defense response | 40/1272 | 278/18723 | 5.40e-06 | 1.66e-04 | 40 |
GO:007124119 | Thyroid | HT | cellular response to inorganic substance | 34/1272 | 226/18723 | 1.03e-05 | 2.79e-04 | 34 |
GO:007124820 | Thyroid | HT | cellular response to metal ion | 27/1272 | 197/18723 | 3.85e-04 | 4.85e-03 | 27 |
GO:0002675 | Thyroid | HT | positive regulation of acute inflammatory response | 7/1272 | 28/18723 | 2.19e-03 | 1.88e-02 | 7 |
GO:005159218 | Thyroid | HT | response to calcium ion | 19/1272 | 149/18723 | 5.92e-03 | 3.76e-02 | 19 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LOX | insertion | In_Frame_Ins | novel | c.899_900insAAGATATCTCTGTTTTTTCACCTGTGAAACCATTCCTTCCTTCTGTTT | p.Glu300_Phe301insArgTyrLeuCysPhePheThrCysGluThrIleProSerPheCysLeu | p.E300_F301insRYLCFFTCETIPSFCL | P28300 | protein_coding | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD | ||
LOX | SNV | Missense_Mutation | novel | c.1202G>A | p.Arg401His | p.R401H | P28300 | protein_coding | tolerated(0.66) | benign(0.07) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
LOX | SNV | Missense_Mutation | c.1010N>A | p.Arg337Gln | p.R337Q | P28300 | protein_coding | deleterious(0.02) | probably_damaging(0.98) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
LOX | SNV | Missense_Mutation | c.49G>A | p.Ala17Thr | p.A17T | P28300 | protein_coding | tolerated(0.37) | benign(0) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
LOX | SNV | Missense_Mutation | novel | c.761N>C | p.Val254Ala | p.V254A | P28300 | protein_coding | tolerated(0.52) | benign(0.048) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
LOX | SNV | Missense_Mutation | c.19G>A | p.Val7Met | p.V7M | P28300 | protein_coding | tolerated(0.08) | benign(0.003) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LOX | SNV | Missense_Mutation | c.842N>A | p.Arg281Gln | p.R281Q | P28300 | protein_coding | deleterious(0.02) | possibly_damaging(0.821) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
LOX | SNV | Missense_Mutation | rs566461481 | c.364N>T | p.Arg122Cys | p.R122C | P28300 | protein_coding | deleterious(0.01) | benign(0.001) | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LOX | SNV | Missense_Mutation | c.76G>A | p.Ala26Thr | p.A26T | P28300 | protein_coding | tolerated(0.61) | benign(0) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LOX | SNV | Missense_Mutation | c.842N>A | p.Arg281Gln | p.R281Q | P28300 | protein_coding | deleterious(0.02) | possibly_damaging(0.821) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4015 | LOX | ENZYME, DRUGGABLE GENOME | inhibitor | 385612244 | ||
4015 | LOX | ENZYME, DRUGGABLE GENOME | inhibitor | 385612245 |
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