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Gene: IGFBP2 |
Gene summary for IGFBP2 |
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Gene information | Species | Human | Gene symbol | IGFBP2 | Gene ID | 3485 |
Gene name | insulin like growth factor binding protein 2 | |
Gene Alias | IBP2 | |
Cytomap | 2q35 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P18065 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3485 | IGFBP2 | GSM4909281 | Human | Breast | IDC | 1.35e-11 | 3.23e-01 | 0.21 |
3485 | IGFBP2 | GSM4909293 | Human | Breast | IDC | 5.87e-95 | 1.29e+00 | 0.1581 |
3485 | IGFBP2 | GSM4909301 | Human | Breast | IDC | 1.10e-03 | 2.17e-01 | 0.1577 |
3485 | IGFBP2 | GSM4909303 | Human | Breast | IDC | 2.38e-06 | 4.93e-01 | 0.0438 |
3485 | IGFBP2 | GSM4909307 | Human | Breast | IDC | 2.28e-07 | 2.77e-01 | 0.1569 |
3485 | IGFBP2 | GSM4909308 | Human | Breast | IDC | 1.58e-04 | 2.05e-01 | 0.158 |
3485 | IGFBP2 | GSM4909316 | Human | Breast | IDC | 4.73e-08 | 6.75e-01 | 0.21 |
3485 | IGFBP2 | GSM4909319 | Human | Breast | IDC | 2.28e-07 | 5.55e-02 | 0.1563 |
3485 | IGFBP2 | GSM4909321 | Human | Breast | IDC | 8.62e-13 | 4.56e-01 | 0.1559 |
3485 | IGFBP2 | ctrl6 | Human | Breast | Precancer | 3.78e-14 | 6.46e-01 | -0.0061 |
3485 | IGFBP2 | NCCBC3 | Human | Breast | DCIS | 1.61e-02 | 2.63e-01 | 0.1198 |
3485 | IGFBP2 | NCCBC5 | Human | Breast | DCIS | 1.68e-03 | 3.42e-01 | 0.2046 |
3485 | IGFBP2 | P3 | Human | Breast | IDC | 6.53e-05 | 6.65e-01 | 0.1542 |
3485 | IGFBP2 | DCIS2 | Human | Breast | DCIS | 5.83e-06 | -8.19e-02 | 0.0085 |
3485 | IGFBP2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.03e-08 | 4.26e-01 | 0.0155 |
3485 | IGFBP2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.04e-06 | 5.72e-01 | -0.1808 |
3485 | IGFBP2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.76e-02 | 7.79e-01 | 0.0216 |
3485 | IGFBP2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.89e-30 | 1.27e+00 | -0.0811 |
3485 | IGFBP2 | HTA11_78_2000001011 | Human | Colorectum | AD | 5.97e-27 | 1.03e+00 | -0.1088 |
3485 | IGFBP2 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.77e-04 | 4.32e-01 | -0.1954 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00447066 | Prostate | BPH | multi-multicellular organism process | 59/3107 | 220/18723 | 8.01e-05 | 7.66e-04 | 59 |
GO:00480093 | Prostate | BPH | insulin-like growth factor receptor signaling pathway | 16/3107 | 37/18723 | 1.22e-04 | 1.10e-03 | 16 |
GO:004211010 | Prostate | BPH | T cell activation | 111/3107 | 487/18723 | 2.11e-04 | 1.72e-03 | 111 |
GO:000941016 | Prostate | BPH | response to xenobiotic stimulus | 106/3107 | 462/18723 | 2.24e-04 | 1.79e-03 | 106 |
GO:00096129 | Prostate | BPH | response to mechanical stimulus | 55/3107 | 216/18723 | 5.61e-04 | 3.91e-03 | 55 |
GO:000715910 | Prostate | BPH | leukocyte cell-cell adhesion | 86/3107 | 371/18723 | 5.95e-04 | 4.11e-03 | 86 |
GO:190303710 | Prostate | BPH | regulation of leukocyte cell-cell adhesion | 78/3107 | 336/18723 | 9.95e-04 | 6.25e-03 | 78 |
GO:00323558 | Prostate | BPH | response to estradiol | 38/3107 | 141/18723 | 1.25e-03 | 7.57e-03 | 38 |
GO:005086310 | Prostate | BPH | regulation of T cell activation | 76/3107 | 329/18723 | 1.32e-03 | 7.95e-03 | 76 |
GO:002240915 | Prostate | BPH | positive regulation of cell-cell adhesion | 67/3107 | 284/18723 | 1.41e-03 | 8.40e-03 | 67 |
GO:00301786 | Prostate | BPH | negative regulation of Wnt signaling pathway | 43/3107 | 170/18723 | 2.42e-03 | 1.31e-02 | 43 |
GO:00900903 | Prostate | BPH | negative regulation of canonical Wnt signaling pathway | 35/3107 | 137/18723 | 4.90e-03 | 2.32e-02 | 35 |
GO:00421299 | Prostate | BPH | regulation of T cell proliferation | 41/3107 | 171/18723 | 8.09e-03 | 3.52e-02 | 41 |
GO:00436274 | Prostate | BPH | response to estrogen | 21/3107 | 75/18723 | 8.97e-03 | 3.83e-02 | 21 |
GO:19030399 | Prostate | BPH | positive regulation of leukocyte cell-cell adhesion | 54/3107 | 239/18723 | 9.57e-03 | 4.05e-02 | 54 |
GO:00706639 | Prostate | BPH | regulation of leukocyte proliferation | 55/3107 | 245/18723 | 1.02e-02 | 4.29e-02 | 55 |
GO:004209810 | Prostate | BPH | T cell proliferation | 46/3107 | 199/18723 | 1.05e-02 | 4.39e-02 | 46 |
GO:00075848 | Prostate | BPH | response to nutrient | 41/3107 | 174/18723 | 1.09e-02 | 4.50e-02 | 41 |
GO:004854519 | Prostate | Tumor | response to steroid hormone | 118/3246 | 339/18723 | 4.46e-15 | 6.94e-13 | 118 |
GO:001605514 | Prostate | Tumor | Wnt signaling pathway | 131/3246 | 444/18723 | 1.16e-10 | 7.11e-09 | 131 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IGFBP2 | SNV | Missense_Mutation | c.871N>A | p.Gly291Arg | p.G291R | P18065 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3664-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IGFBP2 | SNV | Missense_Mutation | c.751G>A | p.Glu251Lys | p.E251K | P18065 | protein_coding | deleterious(0) | possibly_damaging(0.845) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IGFBP2 | SNV | Missense_Mutation | c.797N>C | p.Leu266Pro | p.L266P | P18065 | protein_coding | tolerated(0.07) | probably_damaging(0.927) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
IGFBP2 | SNV | Missense_Mutation | c.961N>G | p.Thr321Ala | p.T321A | P18065 | protein_coding | tolerated_low_confidence(0.56) | benign(0) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
IGFBP2 | SNV | Missense_Mutation | novel | c.530N>A | p.Gly177Asp | p.G177D | P18065 | protein_coding | tolerated(0.33) | benign(0.07) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IGFBP2 | SNV | Missense_Mutation | c.577N>A | p.Glu193Lys | p.E193K | P18065 | protein_coding | tolerated(0.06) | possibly_damaging(0.604) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
IGFBP2 | SNV | Missense_Mutation | novel | c.463G>A | p.Glu155Lys | p.E155K | P18065 | protein_coding | tolerated(0.05) | benign(0.294) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
IGFBP2 | SNV | Missense_Mutation | novel | c.500N>C | p.Met167Thr | p.M167T | P18065 | protein_coding | tolerated(0.77) | benign(0) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IGFBP2 | SNV | Missense_Mutation | c.838N>T | p.Arg280Cys | p.R280C | P18065 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BS-A0UA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
IGFBP2 | SNV | Missense_Mutation | rs774149508 | c.725N>A | p.Arg242His | p.R242H | P18065 | protein_coding | tolerated(0.06) | benign(0.029) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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