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Gene: GCLM |
Gene summary for GCLM |
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Gene information | Species | Human | Gene symbol | GCLM | Gene ID | 2730 |
Gene name | glutamate-cysteine ligase modifier subunit | |
Gene Alias | GLCLR | |
Cytomap | 1p22.1 | |
Gene Type | protein-coding | GO ID | GO:0000096 | UniProtAcc | P48507 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2730 | GCLM | GSM4909281 | Human | Breast | IDC | 6.28e-12 | -5.20e-01 | 0.21 |
2730 | GCLM | GSM4909285 | Human | Breast | IDC | 2.17e-12 | -5.02e-01 | 0.21 |
2730 | GCLM | GSM4909286 | Human | Breast | IDC | 1.61e-15 | -5.37e-01 | 0.1081 |
2730 | GCLM | GSM4909287 | Human | Breast | IDC | 4.14e-05 | -4.09e-01 | 0.2057 |
2730 | GCLM | GSM4909288 | Human | Breast | IDC | 2.46e-02 | -5.55e-01 | 0.0988 |
2730 | GCLM | GSM4909290 | Human | Breast | IDC | 3.29e-06 | -4.88e-01 | 0.2096 |
2730 | GCLM | GSM4909291 | Human | Breast | IDC | 2.57e-04 | -4.88e-01 | 0.1753 |
2730 | GCLM | GSM4909293 | Human | Breast | IDC | 2.44e-12 | -5.56e-01 | 0.1581 |
2730 | GCLM | GSM4909294 | Human | Breast | IDC | 2.07e-17 | -5.70e-01 | 0.2022 |
2730 | GCLM | GSM4909295 | Human | Breast | IDC | 2.04e-02 | -4.71e-01 | 0.0898 |
2730 | GCLM | GSM4909296 | Human | Breast | IDC | 5.36e-19 | -5.83e-01 | 0.1524 |
2730 | GCLM | GSM4909297 | Human | Breast | IDC | 2.22e-16 | -5.50e-01 | 0.1517 |
2730 | GCLM | GSM4909298 | Human | Breast | IDC | 4.62e-14 | -5.55e-01 | 0.1551 |
2730 | GCLM | GSM4909299 | Human | Breast | IDC | 4.85e-12 | -5.26e-01 | 0.035 |
2730 | GCLM | GSM4909301 | Human | Breast | IDC | 5.27e-18 | -5.57e-01 | 0.1577 |
2730 | GCLM | GSM4909302 | Human | Breast | IDC | 9.30e-14 | -5.54e-01 | 0.1545 |
2730 | GCLM | GSM4909304 | Human | Breast | IDC | 6.83e-07 | -4.09e-01 | 0.1636 |
2730 | GCLM | GSM4909305 | Human | Breast | IDC | 1.23e-07 | -5.27e-01 | 0.0436 |
2730 | GCLM | GSM4909306 | Human | Breast | IDC | 4.92e-15 | -5.43e-01 | 0.1564 |
2730 | GCLM | GSM4909307 | Human | Breast | IDC | 1.35e-08 | -4.65e-01 | 0.1569 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:200123329 | Skin | cSCC | regulation of apoptotic signaling pathway | 173/4864 | 356/18723 | 2.25e-20 | 3.44e-18 | 173 |
GO:000697929 | Skin | cSCC | response to oxidative stress | 184/4864 | 446/18723 | 8.57e-13 | 4.89e-11 | 184 |
GO:200123429 | Skin | cSCC | negative regulation of apoptotic signaling pathway | 101/4864 | 224/18723 | 4.17e-10 | 1.70e-08 | 101 |
GO:000863726 | Skin | cSCC | apoptotic mitochondrial changes | 55/4864 | 107/18723 | 1.63e-08 | 4.91e-07 | 55 |
GO:200123628 | Skin | cSCC | regulation of extrinsic apoptotic signaling pathway | 68/4864 | 151/18723 | 3.01e-07 | 6.12e-06 | 68 |
GO:009719128 | Skin | cSCC | extrinsic apoptotic signaling pathway | 91/4864 | 219/18723 | 3.31e-07 | 6.63e-06 | 91 |
GO:000756827 | Skin | cSCC | aging | 127/4864 | 339/18723 | 1.80e-06 | 3.02e-05 | 127 |
GO:005188118 | Skin | cSCC | regulation of mitochondrial membrane potential | 38/4864 | 74/18723 | 2.67e-06 | 4.28e-05 | 38 |
GO:007099729 | Skin | cSCC | neuron death | 133/4864 | 361/18723 | 2.91e-06 | 4.58e-05 | 133 |
GO:00065758 | Skin | cSCC | cellular modified amino acid metabolic process | 73/4864 | 188/18723 | 7.11e-05 | 6.85e-04 | 73 |
GO:003166728 | Skin | cSCC | response to nutrient levels | 160/4864 | 474/18723 | 8.44e-05 | 8.02e-04 | 160 |
GO:199082317 | Skin | cSCC | response to leukemia inhibitory factor | 42/4864 | 95/18723 | 8.79e-05 | 8.27e-04 | 42 |
GO:00423987 | Skin | cSCC | cellular modified amino acid biosynthetic process | 24/4864 | 46/18723 | 1.32e-04 | 1.19e-03 | 24 |
GO:199083016 | Skin | cSCC | cellular response to leukemia inhibitory factor | 41/4864 | 94/18723 | 1.53e-04 | 1.35e-03 | 41 |
GO:190121426 | Skin | cSCC | regulation of neuron death | 112/4864 | 319/18723 | 1.71e-04 | 1.48e-03 | 112 |
GO:007123021 | Skin | cSCC | cellular response to amino acid stimulus | 32/4864 | 71/18723 | 3.84e-04 | 3.01e-03 | 32 |
GO:005140225 | Skin | cSCC | neuron apoptotic process | 88/4864 | 246/18723 | 4.04e-04 | 3.16e-03 | 88 |
GO:000110123 | Skin | cSCC | response to acid chemical | 53/4864 | 135/18723 | 4.79e-04 | 3.61e-03 | 53 |
GO:0009410110 | Skin | cSCC | response to xenobiotic stimulus | 151/4864 | 462/18723 | 6.76e-04 | 4.82e-03 | 151 |
GO:004320014 | Skin | cSCC | response to amino acid | 46/4864 | 116/18723 | 8.50e-04 | 5.86e-03 | 46 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0421610 | Breast | Precancer | Ferroptosis | 11/684 | 41/8465 | 2.95e-04 | 2.45e-03 | 1.88e-03 | 11 |
hsa0048010 | Breast | Precancer | Glutathione metabolism | 12/684 | 57/8465 | 1.68e-03 | 1.08e-02 | 8.30e-03 | 12 |
hsa0421613 | Breast | Precancer | Ferroptosis | 11/684 | 41/8465 | 2.95e-04 | 2.45e-03 | 1.88e-03 | 11 |
hsa0048013 | Breast | Precancer | Glutathione metabolism | 12/684 | 57/8465 | 1.68e-03 | 1.08e-02 | 8.30e-03 | 12 |
hsa0421623 | Breast | IDC | Ferroptosis | 12/867 | 41/8465 | 5.87e-04 | 4.89e-03 | 3.66e-03 | 12 |
hsa0421633 | Breast | IDC | Ferroptosis | 12/867 | 41/8465 | 5.87e-04 | 4.89e-03 | 3.66e-03 | 12 |
hsa0421642 | Breast | DCIS | Ferroptosis | 12/846 | 41/8465 | 4.69e-04 | 3.69e-03 | 2.72e-03 | 12 |
hsa0048041 | Breast | DCIS | Glutathione metabolism | 13/846 | 57/8465 | 3.44e-03 | 1.98e-02 | 1.46e-02 | 13 |
hsa0421652 | Breast | DCIS | Ferroptosis | 12/846 | 41/8465 | 4.69e-04 | 3.69e-03 | 2.72e-03 | 12 |
hsa0048051 | Breast | DCIS | Glutathione metabolism | 13/846 | 57/8465 | 3.44e-03 | 1.98e-02 | 1.46e-02 | 13 |
hsa0421628 | Esophagus | HGIN | Ferroptosis | 15/1383 | 41/8465 | 1.35e-03 | 1.26e-02 | 1.00e-02 | 15 |
hsa04216111 | Esophagus | HGIN | Ferroptosis | 15/1383 | 41/8465 | 1.35e-03 | 1.26e-02 | 1.00e-02 | 15 |
hsa0048018 | Esophagus | ESCC | Glutathione metabolism | 44/4205 | 57/8465 | 1.81e-05 | 9.03e-05 | 4.63e-05 | 44 |
hsa0421629 | Esophagus | ESCC | Ferroptosis | 33/4205 | 41/8465 | 4.58e-05 | 1.99e-04 | 1.02e-04 | 33 |
hsa012405 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa0048019 | Esophagus | ESCC | Glutathione metabolism | 44/4205 | 57/8465 | 1.81e-05 | 9.03e-05 | 4.63e-05 | 44 |
hsa0421638 | Esophagus | ESCC | Ferroptosis | 33/4205 | 41/8465 | 4.58e-05 | 1.99e-04 | 1.02e-04 | 33 |
hsa0124012 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa004809 | Liver | Cirrhotic | Glutathione metabolism | 30/2530 | 57/8465 | 2.63e-04 | 1.72e-03 | 1.06e-03 | 30 |
hsa01240 | Liver | Cirrhotic | Biosynthesis of cofactors | 66/2530 | 153/8465 | 3.11e-04 | 1.99e-03 | 1.23e-03 | 66 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GCLM | SNV | Missense_Mutation | novel | c.295N>C | p.Glu99Gln | p.E99Q | P48507 | protein_coding | tolerated(0.47) | benign(0.072) | TCGA-OL-A5RZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR |
GCLM | insertion | Nonsense_Mutation | novel | c.502_503insTAAACTTTAATCACTGTGGATTGTGATTTTTC | p.Asp168ValfsTer9 | p.D168Vfs*9 | P48507 | protein_coding | TCGA-AN-A049-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
GCLM | SNV | Missense_Mutation | c.226C>T | p.His76Tyr | p.H76Y | P48507 | protein_coding | deleterious(0.01) | benign(0.278) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
GCLM | SNV | Missense_Mutation | novel | c.133G>A | p.Asp45Asn | p.D45N | P48507 | protein_coding | deleterious(0) | benign(0.273) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
GCLM | SNV | Missense_Mutation | rs773867359 | c.383N>T | p.Ala128Val | p.A128V | P48507 | protein_coding | deleterious(0.01) | probably_damaging(0.971) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
GCLM | SNV | Missense_Mutation | c.635T>C | p.Leu212Ser | p.L212S | P48507 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GCLM | SNV | Missense_Mutation | rs761296185 | c.716N>T | p.Ala239Val | p.A239V | P48507 | protein_coding | tolerated(0.27) | benign(0) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
GCLM | SNV | Missense_Mutation | novel | c.820T>C | p.Ser274Pro | p.S274P | P48507 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GCLM | SNV | Missense_Mutation | novel | c.815G>T | p.Arg272Met | p.R272M | P48507 | protein_coding | tolerated_low_confidence(0.06) | benign(0.044) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
GCLM | SNV | Missense_Mutation | c.523C>A | p.Leu175Met | p.L175M | P48507 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2730 | GCLM | ENZYME | PMSG | 11780957 | ||
2730 | GCLM | ENZYME | ANTIOXIDANT | 12637989 | ||
2730 | GCLM | ENZYME | H2O2 | 7615092 | ||
2730 | GCLM | ENZYME | CAROTENOID | 15657364 | ||
2730 | GCLM | ENZYME | CISPLATIN | CISPLATIN | 10399958 | |
2730 | GCLM | ENZYME | SULFORAPHANE | SULFORAPHANE | 11535546 | |
2730 | GCLM | ENZYME | MELATONIN | MELATONIN | 10515588 |
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