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Gene: ENY2 |
Gene summary for ENY2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ENY2 | Gene ID | 56943 |
Gene name | ENY2 transcription and export complex 2 subunit | |
Gene Alias | DC6 | |
Cytomap | 8q23.1 | |
Gene Type | protein-coding | GO ID | GO:0001678 | UniProtAcc | Q9NPA8 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56943 | ENY2 | GSM4909281 | Human | Breast | IDC | 6.05e-86 | 1.01e+00 | 0.21 |
56943 | ENY2 | GSM4909282 | Human | Breast | IDC | 2.02e-35 | 7.46e-01 | -0.0288 |
56943 | ENY2 | GSM4909285 | Human | Breast | IDC | 1.44e-15 | 4.58e-01 | 0.21 |
56943 | ENY2 | GSM4909286 | Human | Breast | IDC | 5.86e-04 | 2.45e-01 | 0.1081 |
56943 | ENY2 | GSM4909287 | Human | Breast | IDC | 2.12e-42 | 7.07e-01 | 0.2057 |
56943 | ENY2 | GSM4909288 | Human | Breast | IDC | 2.38e-06 | 3.31e-01 | 0.0988 |
56943 | ENY2 | GSM4909290 | Human | Breast | IDC | 2.86e-12 | 4.80e-01 | 0.2096 |
56943 | ENY2 | GSM4909291 | Human | Breast | IDC | 2.82e-05 | 3.67e-01 | 0.1753 |
56943 | ENY2 | GSM4909292 | Human | Breast | IDC | 4.99e-05 | 5.59e-01 | 0.1236 |
56943 | ENY2 | GSM4909293 | Human | Breast | IDC | 5.01e-03 | 2.58e-01 | 0.1581 |
56943 | ENY2 | GSM4909294 | Human | Breast | IDC | 5.33e-17 | 3.56e-01 | 0.2022 |
56943 | ENY2 | GSM4909295 | Human | Breast | IDC | 7.77e-03 | 3.47e-01 | 0.0898 |
56943 | ENY2 | GSM4909296 | Human | Breast | IDC | 1.21e-16 | 1.77e-01 | 0.1524 |
56943 | ENY2 | GSM4909297 | Human | Breast | IDC | 2.51e-22 | -2.58e-02 | 0.1517 |
56943 | ENY2 | GSM4909301 | Human | Breast | IDC | 8.09e-08 | 3.06e-01 | 0.1577 |
56943 | ENY2 | GSM4909304 | Human | Breast | IDC | 4.42e-07 | 3.69e-01 | 0.1636 |
56943 | ENY2 | GSM4909306 | Human | Breast | IDC | 5.15e-14 | 5.05e-01 | 0.1564 |
56943 | ENY2 | GSM4909307 | Human | Breast | IDC | 6.62e-04 | 2.57e-01 | 0.1569 |
56943 | ENY2 | GSM4909308 | Human | Breast | IDC | 1.15e-13 | 4.14e-01 | 0.158 |
56943 | ENY2 | GSM4909309 | Human | Breast | IDC | 3.12e-05 | 2.32e-01 | 0.0483 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007132615 | Prostate | Tumor | cellular response to monosaccharide stimulus | 39/3246 | 154/18723 | 7.73e-03 | 3.44e-02 | 39 |
GO:006117812 | Prostate | Tumor | regulation of insulin secretion involved in cellular response to glucose stimulus | 19/3246 | 64/18723 | 1.03e-02 | 4.31e-02 | 19 |
GO:007132216 | Prostate | Tumor | cellular response to carbohydrate stimulus | 40/3246 | 163/18723 | 1.21e-02 | 4.93e-02 | 40 |
GO:000691324 | Skin | cSCC | nucleocytoplasmic transport | 162/4864 | 301/18723 | 4.20e-25 | 1.10e-22 | 162 |
GO:005116924 | Skin | cSCC | nuclear transport | 162/4864 | 301/18723 | 4.20e-25 | 1.10e-22 | 162 |
GO:0006403111 | Skin | cSCC | RNA localization | 120/4864 | 201/18723 | 4.17e-24 | 1.01e-21 | 120 |
GO:0051168111 | Skin | cSCC | nuclear export | 91/4864 | 154/18723 | 3.33e-18 | 4.18e-16 | 91 |
GO:005065719 | Skin | cSCC | nucleic acid transport | 92/4864 | 163/18723 | 1.35e-16 | 1.33e-14 | 92 |
GO:005065819 | Skin | cSCC | RNA transport | 92/4864 | 163/18723 | 1.35e-16 | 1.33e-14 | 92 |
GO:005123619 | Skin | cSCC | establishment of RNA localization | 93/4864 | 166/18723 | 1.78e-16 | 1.69e-14 | 93 |
GO:005102816 | Skin | cSCC | mRNA transport | 77/4864 | 130/18723 | 1.06e-15 | 8.95e-14 | 77 |
GO:007116613 | Skin | cSCC | ribonucleoprotein complex localization | 49/4864 | 77/18723 | 3.94e-12 | 2.13e-10 | 49 |
GO:001593119 | Skin | cSCC | nucleobase-containing compound transport | 105/4864 | 222/18723 | 5.49e-12 | 2.89e-10 | 105 |
GO:007142613 | Skin | cSCC | ribonucleoprotein complex export from nucleus | 48/4864 | 76/18723 | 9.76e-12 | 4.97e-10 | 48 |
GO:001657024 | Skin | cSCC | histone modification | 179/4864 | 463/18723 | 9.65e-10 | 3.74e-08 | 179 |
GO:000640513 | Skin | cSCC | RNA export from nucleus | 46/4864 | 84/18723 | 1.89e-08 | 5.56e-07 | 46 |
GO:003150315 | Skin | cSCC | protein-containing complex localization | 95/4864 | 220/18723 | 2.00e-08 | 5.82e-07 | 95 |
GO:000635415 | Skin | cSCC | DNA-templated transcription, elongation | 48/4864 | 91/18723 | 4.58e-08 | 1.19e-06 | 48 |
GO:000636815 | Skin | cSCC | transcription elongation from RNA polymerase II promoter | 39/4864 | 69/18723 | 7.15e-08 | 1.78e-06 | 39 |
GO:000640612 | Skin | cSCC | mRNA export from nucleus | 34/4864 | 59/18723 | 2.59e-07 | 5.33e-06 | 34 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ENY2 | SNV | Missense_Mutation | c.68N>T | p.Thr23Ile | p.T23I | Q9NPA8 | protein_coding | deleterious(0.02) | possibly_damaging(0.462) | TCGA-A6-6138-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ENY2 | SNV | Missense_Mutation | c.61A>G | p.Ile21Val | p.I21V | Q9NPA8 | protein_coding | tolerated(0.53) | benign(0.005) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ENY2 | SNV | Missense_Mutation | novel | c.41C>T | p.Ala14Val | p.A14V | Q9NPA8 | protein_coding | tolerated(0.06) | benign(0.379) | TCGA-AJ-A8CW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ENY2 | SNV | Missense_Mutation | rs754316009 | c.44N>T | p.Ala15Val | p.A15V | Q9NPA8 | protein_coding | tolerated(0.58) | benign(0) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ENY2 | SNV | Missense_Mutation | novel | c.179N>G | p.Glu60Gly | p.E60G | Q9NPA8 | protein_coding | tolerated(0.08) | benign(0.098) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
ENY2 | SNV | Missense_Mutation | novel | c.298N>G | p.Ser100Gly | p.S100G | Q9NPA8 | protein_coding | tolerated(0.15) | benign(0) | TCGA-FI-A3PV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ENY2 | SNV | Missense_Mutation | c.282N>A | p.Phe94Leu | p.F94L | Q9NPA8 | protein_coding | tolerated(0.07) | possibly_damaging(0.752) | TCGA-44-7670-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
ENY2 | SNV | Missense_Mutation | rs754316009 | c.44N>T | p.Ala15Val | p.A15V | Q9NPA8 | protein_coding | tolerated(0.58) | benign(0) | TCGA-86-A4JF-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | unknown | PD |
ENY2 | SNV | Missense_Mutation | c.256G>C | p.Glu86Gln | p.E86Q | Q9NPA8 | protein_coding | deleterious(0) | benign(0.435) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
ENY2 | SNV | Missense_Mutation | novel | c.18N>A | p.Met6Ile | p.M6I | Q9NPA8 | protein_coding | tolerated(0.1) | benign(0.005) | TCGA-CV-6441-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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