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Gene: BNIP3L |
Gene summary for BNIP3L |
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Gene information | Species | Human | Gene symbol | BNIP3L | Gene ID | 665 |
Gene name | BCL2 interacting protein 3 like | |
Gene Alias | BNIP3a | |
Cytomap | 8p21.2 | |
Gene Type | protein-coding | GO ID | GO:0000422 | UniProtAcc | O60238 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
665 | BNIP3L | GSM4909286 | Human | Breast | IDC | 1.07e-07 | -2.72e-01 | 0.1081 |
665 | BNIP3L | GSM4909287 | Human | Breast | IDC | 2.83e-09 | -3.35e-01 | 0.2057 |
665 | BNIP3L | GSM4909291 | Human | Breast | IDC | 6.78e-05 | -3.31e-01 | 0.1753 |
665 | BNIP3L | GSM4909296 | Human | Breast | IDC | 6.98e-13 | -3.08e-01 | 0.1524 |
665 | BNIP3L | GSM4909297 | Human | Breast | IDC | 3.80e-13 | -3.28e-01 | 0.1517 |
665 | BNIP3L | GSM4909304 | Human | Breast | IDC | 9.96e-04 | -2.79e-01 | 0.1636 |
665 | BNIP3L | GSM4909309 | Human | Breast | IDC | 2.77e-05 | -2.90e-01 | 0.0483 |
665 | BNIP3L | GSM4909311 | Human | Breast | IDC | 2.20e-18 | -3.67e-01 | 0.1534 |
665 | BNIP3L | GSM4909312 | Human | Breast | IDC | 1.32e-13 | -3.03e-01 | 0.1552 |
665 | BNIP3L | GSM4909315 | Human | Breast | IDC | 3.26e-02 | 3.06e-01 | 0.21 |
665 | BNIP3L | GSM4909319 | Human | Breast | IDC | 1.63e-27 | -4.64e-01 | 0.1563 |
665 | BNIP3L | GSM4909320 | Human | Breast | IDC | 6.02e-07 | -3.56e-01 | 0.1575 |
665 | BNIP3L | GSM4909321 | Human | Breast | IDC | 2.73e-13 | -2.86e-01 | 0.1559 |
665 | BNIP3L | ctrl6 | Human | Breast | Precancer | 3.83e-26 | 8.96e-01 | -0.0061 |
665 | BNIP3L | brca3 | Human | Breast | Precancer | 3.49e-12 | 4.87e-01 | -0.0263 |
665 | BNIP3L | brca7 | Human | Breast | Precancer | 2.29e-05 | 7.43e-01 | -0.009 |
665 | BNIP3L | brca10 | Human | Breast | Precancer | 1.84e-24 | 7.52e-01 | -0.0029 |
665 | BNIP3L | M2 | Human | Breast | IDC | 8.28e-04 | -4.40e-01 | 0.21 |
665 | BNIP3L | NCCBC14 | Human | Breast | DCIS | 6.77e-09 | 9.17e-02 | 0.2021 |
665 | BNIP3L | NCCBC5 | Human | Breast | DCIS | 7.90e-16 | -1.77e-01 | 0.2046 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00070069 | Prostate | BPH | mitochondrial membrane organization | 35/3107 | 116/18723 | 1.98e-04 | 1.63e-03 | 35 |
GO:001082110 | Prostate | BPH | regulation of mitochondrion organization | 41/3107 | 144/18723 | 2.40e-04 | 1.92e-03 | 41 |
GO:00162416 | Prostate | BPH | regulation of macroautophagy | 40/3107 | 141/18723 | 3.09e-04 | 2.37e-03 | 40 |
GO:00905597 | Prostate | BPH | regulation of membrane permeability | 25/3107 | 78/18723 | 5.74e-04 | 3.99e-03 | 25 |
GO:00518818 | Prostate | BPH | regulation of mitochondrial membrane potential | 24/3107 | 74/18723 | 6.06e-04 | 4.16e-03 | 24 |
GO:19031468 | Prostate | BPH | regulation of autophagy of mitochondrion | 13/3107 | 33/18723 | 1.50e-03 | 8.85e-03 | 13 |
GO:19037477 | Prostate | BPH | regulation of establishment of protein localization to mitochondrion | 17/3107 | 50/18723 | 2.06e-03 | 1.16e-02 | 17 |
GO:19035336 | Prostate | BPH | regulation of protein targeting | 23/3107 | 81/18723 | 5.35e-03 | 2.49e-02 | 23 |
GO:00162392 | Prostate | BPH | positive regulation of macroautophagy | 19/3107 | 63/18723 | 5.36e-03 | 2.49e-02 | 19 |
GO:00469027 | Prostate | BPH | regulation of mitochondrial membrane permeability | 19/3107 | 63/18723 | 5.36e-03 | 2.49e-02 | 19 |
GO:19032146 | Prostate | BPH | regulation of protein targeting to mitochondrion | 14/3107 | 44/18723 | 9.52e-03 | 4.03e-02 | 14 |
GO:00973458 | Prostate | BPH | mitochondrial outer membrane permeabilization | 11/3107 | 32/18723 | 1.11e-02 | 4.55e-02 | 11 |
GO:00109173 | Prostate | BPH | negative regulation of mitochondrial membrane potential | 6/3107 | 13/18723 | 1.24e-02 | 4.94e-02 | 6 |
GO:007259417 | Prostate | Tumor | establishment of protein localization to organelle | 151/3246 | 422/18723 | 3.19e-20 | 2.83e-17 | 151 |
GO:000989619 | Prostate | Tumor | positive regulation of catabolic process | 155/3246 | 492/18723 | 5.62e-15 | 8.52e-13 | 155 |
GO:000660519 | Prostate | Tumor | protein targeting | 109/3246 | 314/18723 | 6.11e-14 | 7.30e-12 | 109 |
GO:003133119 | Prostate | Tumor | positive regulation of cellular catabolic process | 134/3246 | 427/18723 | 5.54e-13 | 5.84e-11 | 134 |
GO:003238614 | Prostate | Tumor | regulation of intracellular transport | 111/3246 | 337/18723 | 1.83e-12 | 1.65e-10 | 111 |
GO:003315717 | Prostate | Tumor | regulation of intracellular protein transport | 81/3246 | 229/18723 | 3.47e-11 | 2.37e-09 | 81 |
GO:000683917 | Prostate | Tumor | mitochondrial transport | 84/3246 | 254/18723 | 7.17e-10 | 3.57e-08 | 84 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0413716 | Breast | Precancer | Mitophagy - animal | 15/684 | 72/8465 | 5.22e-04 | 3.93e-03 | 3.01e-03 | 15 |
hsa0413717 | Breast | Precancer | Mitophagy - animal | 15/684 | 72/8465 | 5.22e-04 | 3.93e-03 | 3.01e-03 | 15 |
hsa0413723 | Breast | IDC | Mitophagy - animal | 17/867 | 72/8465 | 7.61e-04 | 6.04e-03 | 4.52e-03 | 17 |
hsa0413733 | Breast | IDC | Mitophagy - animal | 17/867 | 72/8465 | 7.61e-04 | 6.04e-03 | 4.52e-03 | 17 |
hsa0413742 | Breast | DCIS | Mitophagy - animal | 17/846 | 72/8465 | 5.75e-04 | 4.42e-03 | 3.26e-03 | 17 |
hsa0413752 | Breast | DCIS | Mitophagy - animal | 17/846 | 72/8465 | 5.75e-04 | 4.42e-03 | 3.26e-03 | 17 |
hsa0413720 | Endometrium | AEH | Mitophagy - animal | 21/1197 | 72/8465 | 7.03e-04 | 4.86e-03 | 3.56e-03 | 21 |
hsa04137110 | Endometrium | AEH | Mitophagy - animal | 21/1197 | 72/8465 | 7.03e-04 | 4.86e-03 | 3.56e-03 | 21 |
hsa0413725 | Endometrium | EEC | Mitophagy - animal | 22/1237 | 72/8465 | 4.12e-04 | 3.30e-03 | 2.46e-03 | 22 |
hsa0413735 | Endometrium | EEC | Mitophagy - animal | 22/1237 | 72/8465 | 4.12e-04 | 3.30e-03 | 2.46e-03 | 22 |
hsa04137210 | Esophagus | ESCC | Mitophagy - animal | 54/4205 | 72/8465 | 9.33e-06 | 4.96e-05 | 2.54e-05 | 54 |
hsa0413738 | Esophagus | ESCC | Mitophagy - animal | 54/4205 | 72/8465 | 9.33e-06 | 4.96e-05 | 2.54e-05 | 54 |
hsa0413721 | Liver | Cirrhotic | Mitophagy - animal | 39/2530 | 72/8465 | 1.38e-05 | 1.24e-04 | 7.64e-05 | 39 |
hsa0413731 | Liver | Cirrhotic | Mitophagy - animal | 39/2530 | 72/8465 | 1.38e-05 | 1.24e-04 | 7.64e-05 | 39 |
hsa0413741 | Liver | HCC | Mitophagy - animal | 53/4020 | 72/8465 | 5.49e-06 | 4.59e-05 | 2.56e-05 | 53 |
hsa0413751 | Liver | HCC | Mitophagy - animal | 53/4020 | 72/8465 | 5.49e-06 | 4.59e-05 | 2.56e-05 | 53 |
hsa0413728 | Oral cavity | OSCC | Mitophagy - animal | 58/3704 | 72/8465 | 1.48e-10 | 2.07e-09 | 1.05e-09 | 58 |
hsa04137112 | Oral cavity | OSCC | Mitophagy - animal | 58/3704 | 72/8465 | 1.48e-10 | 2.07e-09 | 1.05e-09 | 58 |
hsa0413743 | Oral cavity | EOLP | Mitophagy - animal | 25/1218 | 72/8465 | 1.18e-05 | 6.69e-05 | 3.95e-05 | 25 |
hsa0413753 | Oral cavity | EOLP | Mitophagy - animal | 25/1218 | 72/8465 | 1.18e-05 | 6.69e-05 | 3.95e-05 | 25 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BNIP3L | SNV | Missense_Mutation | c.402N>T | p.Leu134Phe | p.L134F | O60238 | protein_coding | deleterious(0) | probably_damaging(0.919) | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BNIP3L | SNV | Missense_Mutation | rs762423471 | c.403N>G | p.Lys135Glu | p.K135E | O60238 | protein_coding | deleterious(0.01) | possibly_damaging(0.652) | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BNIP3L | insertion | Frame_Shift_Ins | novel | c.551_552insTTGGTATCTTTTCTGTCTAGATTTTTCTTTGT | p.Glu184AspfsTer14 | p.E184Dfs*14 | O60238 | protein_coding | TCGA-A8-A09D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | ||
BNIP3L | SNV | Missense_Mutation | rs747118549 | c.394G>A | p.Glu132Lys | p.E132K | O60238 | protein_coding | deleterious(0.02) | benign(0.114) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
BNIP3L | SNV | Missense_Mutation | c.287N>A | p.Pro96His | p.P96H | O60238 | protein_coding | tolerated(0.07) | probably_damaging(0.987) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
BNIP3L | SNV | Missense_Mutation | novel | c.556N>A | p.Leu186Met | p.L186M | O60238 | protein_coding | deleterious(0.04) | probably_damaging(0.985) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
BNIP3L | SNV | Missense_Mutation | c.223N>A | p.Leu75Ile | p.L75I | O60238 | protein_coding | deleterious(0) | possibly_damaging(0.793) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
BNIP3L | SNV | Missense_Mutation | c.445G>A | p.Glu149Lys | p.E149K | O60238 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
BNIP3L | deletion | Frame_Shift_Del | novel | c.163delN | p.Leu57TrpfsTer69 | p.L57Wfs*69 | O60238 | protein_coding | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
BNIP3L | SNV | Missense_Mutation | rs773482295 | c.413C>T | p.Ala138Val | p.A138V | O60238 | protein_coding | tolerated(0.45) | benign(0.012) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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