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Gene: RHOA |
Gene summary for RHOA |
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Gene information | Species | Human | Gene symbol | RHOA | Gene ID | 387 |
Gene name | ras homolog family member A | |
Gene Alias | ARH12 | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | A0A024R324 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
387 | RHOA | CA_HPV_1 | Human | Cervix | CC | 4.50e-11 | 1.49e-01 | 0.0264 |
387 | RHOA | CA_HPV_3 | Human | Cervix | CC | 5.14e-05 | -9.20e-03 | 0.0414 |
387 | RHOA | CCI_1 | Human | Cervix | CC | 1.73e-07 | -6.40e-01 | 0.528 |
387 | RHOA | CCII_1 | Human | Cervix | CC | 5.60e-27 | -8.70e-01 | 0.3249 |
387 | RHOA | sample3 | Human | Cervix | CC | 1.87e-06 | -1.36e-01 | 0.1387 |
387 | RHOA | L1 | Human | Cervix | CC | 8.50e-11 | -1.69e-01 | 0.0802 |
387 | RHOA | T1 | Human | Cervix | CC | 3.99e-11 | -4.43e-01 | 0.0918 |
387 | RHOA | T3 | Human | Cervix | CC | 1.12e-09 | -1.34e-01 | 0.1389 |
387 | RHOA | HTA11_2487_2000001011 | Human | Colorectum | SER | 9.90e-18 | 1.27e+00 | -0.1808 |
387 | RHOA | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.15e-14 | 1.30e+00 | -0.0811 |
387 | RHOA | HTA11_78_2000001011 | Human | Colorectum | AD | 7.49e-24 | 1.39e+00 | -0.1088 |
387 | RHOA | HTA11_347_2000001011 | Human | Colorectum | AD | 2.90e-51 | 1.58e+00 | -0.1954 |
387 | RHOA | HTA11_411_2000001011 | Human | Colorectum | SER | 5.14e-16 | 1.87e+00 | -0.2602 |
387 | RHOA | HTA11_2112_2000001011 | Human | Colorectum | SER | 9.14e-05 | 1.07e+00 | -0.2196 |
387 | RHOA | HTA11_83_2000001011 | Human | Colorectum | SER | 6.77e-16 | 1.38e+00 | -0.1526 |
387 | RHOA | HTA11_696_2000001011 | Human | Colorectum | AD | 1.22e-16 | 8.46e-01 | -0.1464 |
387 | RHOA | HTA11_866_2000001011 | Human | Colorectum | AD | 2.83e-04 | 4.53e-01 | -0.1001 |
387 | RHOA | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.19e-20 | 1.12e+00 | -0.059 |
387 | RHOA | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.11e-19 | 1.46e+00 | -0.1706 |
387 | RHOA | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.89e-20 | 1.67e+00 | -0.2061 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004325441 | Stomach | SIM | regulation of protein-containing complex assembly | 36/708 | 428/18723 | 6.89e-06 | 2.71e-04 | 36 |
GO:011005351 | Stomach | SIM | regulation of actin filament organization | 27/708 | 278/18723 | 7.56e-06 | 2.92e-04 | 27 |
GO:003297041 | Stomach | SIM | regulation of actin filament-based process | 34/708 | 397/18723 | 8.43e-06 | 3.18e-04 | 34 |
GO:00322315 | Stomach | SIM | regulation of actin filament bundle assembly | 15/708 | 105/18723 | 9.40e-06 | 3.47e-04 | 15 |
GO:003133441 | Stomach | SIM | positive regulation of protein-containing complex assembly | 24/708 | 237/18723 | 1.20e-05 | 4.30e-04 | 24 |
GO:000974351 | Stomach | SIM | response to carbohydrate | 25/708 | 253/18723 | 1.21e-05 | 4.30e-04 | 25 |
GO:00342505 | Stomach | SIM | positive regulation of cellular amide metabolic process | 19/708 | 162/18723 | 1.23e-05 | 4.32e-04 | 19 |
GO:00725935 | Stomach | SIM | reactive oxygen species metabolic process | 24/708 | 239/18723 | 1.38e-05 | 4.74e-04 | 24 |
GO:004586251 | Stomach | SIM | positive regulation of proteolysis | 32/708 | 372/18723 | 1.41e-05 | 4.83e-04 | 32 |
GO:003428451 | Stomach | SIM | response to monosaccharide | 23/708 | 225/18723 | 1.55e-05 | 5.19e-04 | 23 |
GO:003295651 | Stomach | SIM | regulation of actin cytoskeleton organization | 31/708 | 358/18723 | 1.69e-05 | 5.45e-04 | 31 |
GO:00109525 | Stomach | SIM | positive regulation of peptidase activity | 21/708 | 197/18723 | 1.92e-05 | 6.11e-04 | 21 |
GO:00322335 | Stomach | SIM | positive regulation of actin filament bundle assembly | 11/708 | 63/18723 | 2.14e-05 | 6.74e-04 | 11 |
GO:00508635 | Stomach | SIM | regulation of T cell activation | 29/708 | 329/18723 | 2.26e-05 | 7.00e-04 | 29 |
GO:000974651 | Stomach | SIM | response to hexose | 22/708 | 219/18723 | 3.09e-05 | 9.18e-04 | 22 |
GO:00514925 | Stomach | SIM | regulation of stress fiber assembly | 13/708 | 91/18723 | 3.67e-05 | 1.05e-03 | 13 |
GO:00362935 | Stomach | SIM | response to decreased oxygen levels | 28/708 | 322/18723 | 3.96e-05 | 1.12e-03 | 28 |
GO:00300385 | Stomach | SIM | contractile actin filament bundle assembly | 14/708 | 106/18723 | 4.55e-05 | 1.26e-03 | 14 |
GO:00431495 | Stomach | SIM | stress fiber assembly | 14/708 | 106/18723 | 4.55e-05 | 1.26e-03 | 14 |
GO:00109505 | Stomach | SIM | positive regulation of endopeptidase activity | 19/708 | 179/18723 | 5.01e-05 | 1.33e-03 | 19 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0541820 | Cervix | CC | Fluid shear stress and atherosclerosis | 50/1267 | 139/8465 | 5.71e-10 | 1.32e-08 | 7.81e-09 | 50 |
hsa0513020 | Cervix | CC | Pathogenic Escherichia coli infection | 63/1267 | 197/8465 | 9.28e-10 | 2.00e-08 | 1.19e-08 | 63 |
hsa0513220 | Cervix | CC | Salmonella infection | 74/1267 | 249/8465 | 1.33e-09 | 2.54e-08 | 1.50e-08 | 74 |
hsa0541720 | Cervix | CC | Lipid and atherosclerosis | 65/1267 | 215/8465 | 6.47e-09 | 1.10e-07 | 6.52e-08 | 65 |
hsa0516318 | Cervix | CC | Human cytomegalovirus infection | 65/1267 | 225/8465 | 4.59e-08 | 6.47e-07 | 3.83e-07 | 65 |
hsa0513120 | Cervix | CC | Shigellosis | 69/1267 | 247/8465 | 7.64e-08 | 1.03e-06 | 6.10e-07 | 69 |
hsa0520516 | Cervix | CC | Proteoglycans in cancer | 60/1267 | 205/8465 | 9.13e-08 | 1.18e-06 | 7.00e-07 | 60 |
hsa0451010 | Cervix | CC | Focal adhesion | 59/1267 | 203/8465 | 1.53e-07 | 1.84e-06 | 1.09e-06 | 59 |
hsa0481016 | Cervix | CC | Regulation of actin cytoskeleton | 64/1267 | 229/8465 | 2.24e-07 | 2.59e-06 | 1.53e-06 | 64 |
hsa0452020 | Cervix | CC | Adherens junction | 33/1267 | 93/8465 | 6.99e-07 | 7.31e-06 | 4.32e-06 | 33 |
hsa0453020 | Cervix | CC | Tight junction | 49/1267 | 169/8465 | 1.87e-06 | 1.78e-05 | 1.05e-05 | 49 |
hsa0467020 | Cervix | CC | Leukocyte transendothelial migration | 36/1267 | 114/8465 | 5.22e-06 | 4.83e-05 | 2.86e-05 | 36 |
hsa0401512 | Cervix | CC | Rap1 signaling pathway | 56/1267 | 210/8465 | 6.23e-06 | 5.61e-05 | 3.32e-05 | 56 |
hsa0414418 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
hsa0513516 | Cervix | CC | Yersinia infection | 39/1267 | 137/8465 | 3.27e-05 | 2.41e-04 | 1.42e-04 | 39 |
hsa0407110 | Cervix | CC | Sphingolipid signaling pathway | 35/1267 | 121/8465 | 5.70e-05 | 3.93e-04 | 2.32e-04 | 35 |
hsa043609 | Cervix | CC | Axon guidance | 47/1267 | 182/8465 | 8.13e-05 | 5.38e-04 | 3.18e-04 | 47 |
hsa0521010 | Cervix | CC | Colorectal cancer | 27/1267 | 86/8465 | 8.60e-05 | 5.57e-04 | 3.30e-04 | 27 |
hsa043109 | Cervix | CC | Wnt signaling pathway | 43/1267 | 171/8465 | 3.03e-04 | 1.64e-03 | 9.68e-04 | 43 |
hsa0472214 | Cervix | CC | Neurotrophin signaling pathway | 32/1267 | 119/8465 | 5.01e-04 | 2.42e-03 | 1.43e-03 | 32 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RHOA | SNV | Missense_Mutation | c.118G>C | p.Glu40Gln | p.E40Q | P61586 | protein_coding | deleterious(0.04) | benign(0.41) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
RHOA | SNV | Missense_Mutation | c.13N>T | p.Arg5Trp | p.R5W | P61586 | protein_coding | deleterious(0.02) | benign(0.013) | TCGA-AC-A3TM-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | CR | |
RHOA | SNV | Missense_Mutation | c.13N>T | p.Arg5Trp | p.R5W | P61586 | protein_coding | deleterious(0.02) | benign(0.013) | TCGA-BH-A0E0-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | |
RHOA | SNV | Missense_Mutation | c.373N>C | p.Glu125Gln | p.E125Q | P61586 | protein_coding | tolerated(0.32) | benign(0.003) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
RHOA | SNV | Missense_Mutation | rs11552761 | c.50N>C | p.Gly17Ala | p.G17A | P61586 | protein_coding | deleterious(0) | benign(0.422) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RHOA | SNV | Missense_Mutation | c.118N>C | p.Glu40Gln | p.E40Q | P61586 | protein_coding | deleterious(0.04) | benign(0.41) | TCGA-GM-A2DO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | CR | |
RHOA | SNV | Missense_Mutation | rs11552761 | c.50N>A | p.Gly17Glu | p.G17E | P61586 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-GM-A3XG-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | CR |
RHOA | insertion | Frame_Shift_Ins | novel | c.561dupA | p.Ser188IlefsTer30 | p.S188Ifs*30 | P61586 | protein_coding | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
RHOA | insertion | Nonsense_Mutation | novel | c.165_166insAGCAAACTAGATGAGTTCCAAATGTAA | p.Leu55_Ala56insSerLysLeuAspGluPheGlnMetTer | p.L55_A56insSKLDEFQM* | P61586 | protein_coding | TCGA-B6-A0IB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
RHOA | SNV | Missense_Mutation | c.318N>G | p.Phe106Leu | p.F106L | P61586 | protein_coding | deleterious(0.03) | benign(0.324) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
387 | RHOA | KINASE, CLINICALLY ACTIONABLE | pravastatin | PRAVASTATIN | 23166513 | |
387 | RHOA | KINASE, CLINICALLY ACTIONABLE | ROTTLERIN | ROTTLERIN | 22093759 | |
387 | RHOA | KINASE, CLINICALLY ACTIONABLE | CLAUSINE E | CLAUSINE E | 22093759 | |
387 | RHOA | KINASE, CLINICALLY ACTIONABLE | simvastatin | SIMVASTATIN | 23166513 |
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