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Gene: TACSTD2 |
Gene summary for TACSTD2 |
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Gene information | Species | Human | Gene symbol | TACSTD2 | Gene ID | 4070 |
Gene name | tumor associated calcium signal transducer 2 | |
Gene Alias | EGP-1 | |
Cytomap | 1p32.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | P09758 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4070 | TACSTD2 | GSM4909281 | Human | Breast | IDC | 8.47e-31 | -8.82e-01 | 0.21 |
4070 | TACSTD2 | GSM4909282 | Human | Breast | IDC | 1.32e-21 | 4.71e-01 | -0.0288 |
4070 | TACSTD2 | GSM4909285 | Human | Breast | IDC | 7.61e-09 | 1.01e-01 | 0.21 |
4070 | TACSTD2 | GSM4909286 | Human | Breast | IDC | 1.90e-83 | -1.49e+00 | 0.1081 |
4070 | TACSTD2 | GSM4909288 | Human | Breast | IDC | 2.86e-06 | -7.81e-01 | 0.0988 |
4070 | TACSTD2 | GSM4909290 | Human | Breast | IDC | 2.22e-26 | -8.21e-01 | 0.2096 |
4070 | TACSTD2 | GSM4909291 | Human | Breast | IDC | 1.10e-24 | -1.00e+00 | 0.1753 |
4070 | TACSTD2 | GSM4909292 | Human | Breast | IDC | 3.41e-04 | -9.50e-01 | 0.1236 |
4070 | TACSTD2 | GSM4909293 | Human | Breast | IDC | 1.83e-33 | -7.57e-01 | 0.1581 |
4070 | TACSTD2 | GSM4909294 | Human | Breast | IDC | 1.34e-26 | -8.61e-01 | 0.2022 |
4070 | TACSTD2 | GSM4909296 | Human | Breast | IDC | 2.23e-23 | -7.87e-01 | 0.1524 |
4070 | TACSTD2 | GSM4909297 | Human | Breast | IDC | 3.79e-07 | -5.30e-01 | 0.1517 |
4070 | TACSTD2 | GSM4909298 | Human | Breast | IDC | 4.47e-27 | -6.79e-01 | 0.1551 |
4070 | TACSTD2 | GSM4909300 | Human | Breast | IDC | 2.04e-02 | 3.32e-01 | 0.0334 |
4070 | TACSTD2 | GSM4909301 | Human | Breast | IDC | 7.48e-20 | -6.41e-01 | 0.1577 |
4070 | TACSTD2 | GSM4909302 | Human | Breast | IDC | 9.22e-18 | -6.63e-01 | 0.1545 |
4070 | TACSTD2 | GSM4909304 | Human | Breast | IDC | 5.32e-47 | -1.01e+00 | 0.1636 |
4070 | TACSTD2 | GSM4909305 | Human | Breast | IDC | 7.21e-04 | 1.61e-01 | 0.0436 |
4070 | TACSTD2 | GSM4909306 | Human | Breast | IDC | 2.82e-11 | -3.19e-01 | 0.1564 |
4070 | TACSTD2 | GSM4909307 | Human | Breast | IDC | 1.86e-18 | -7.36e-01 | 0.1569 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190290412 | Liver | HCC | negative regulation of supramolecular fiber organization | 90/7958 | 167/18723 | 1.90e-03 | 9.69e-03 | 90 |
GO:00016553 | Liver | HCC | urogenital system development | 170/7958 | 338/18723 | 2.15e-03 | 1.08e-02 | 170 |
GO:003003822 | Liver | HCC | contractile actin filament bundle assembly | 60/7958 | 106/18723 | 2.34e-03 | 1.16e-02 | 60 |
GO:004314922 | Liver | HCC | stress fiber assembly | 60/7958 | 106/18723 | 2.34e-03 | 1.16e-02 | 60 |
GO:00018222 | Liver | HCC | kidney development | 148/7958 | 293/18723 | 3.25e-03 | 1.49e-02 | 148 |
GO:00720012 | Liver | HCC | renal system development | 152/7958 | 302/18723 | 3.45e-03 | 1.56e-02 | 152 |
GO:003152911 | Liver | HCC | ruffle organization | 34/7958 | 56/18723 | 4.54e-03 | 1.96e-02 | 34 |
GO:00107711 | Liver | HCC | negative regulation of cell morphogenesis involved in differentiation | 11/7958 | 14/18723 | 6.81e-03 | 2.73e-02 | 11 |
GO:19000251 | Liver | HCC | negative regulation of substrate adhesion-dependent cell spreading | 11/7958 | 14/18723 | 6.81e-03 | 2.73e-02 | 11 |
GO:003223122 | Liver | HCC | regulation of actin filament bundle assembly | 57/7958 | 105/18723 | 9.73e-03 | 3.66e-02 | 57 |
GO:00514946 | Liver | HCC | negative regulation of cytoskeleton organization | 84/7958 | 163/18723 | 1.22e-02 | 4.43e-02 | 84 |
GO:011002022 | Liver | HCC | regulation of actomyosin structure organization | 54/7958 | 100/18723 | 1.33e-02 | 4.76e-02 | 54 |
GO:000166721 | Liver | HCC | ameboidal-type cell migration | 226/7958 | 475/18723 | 1.35e-02 | 4.81e-02 | 226 |
GO:190002432 | Liver | Cyst | regulation of substrate adhesion-dependent cell spreading | 8/496 | 57/18723 | 1.21e-04 | 5.28e-03 | 8 |
GO:190290332 | Liver | Cyst | regulation of supramolecular fiber organization | 22/496 | 383/18723 | 6.04e-04 | 1.73e-02 | 22 |
GO:000701532 | Liver | Cyst | actin filament organization | 24/496 | 442/18723 | 7.70e-04 | 2.07e-02 | 24 |
GO:003444632 | Liver | Cyst | substrate adhesion-dependent cell spreading | 9/496 | 108/18723 | 2.30e-03 | 4.60e-02 | 9 |
GO:00315897 | Lung | IAC | cell-substrate adhesion | 85/2061 | 363/18723 | 8.57e-12 | 4.27e-09 | 85 |
GO:00226048 | Lung | IAC | regulation of cell morphogenesis | 74/2061 | 309/18723 | 6.31e-11 | 1.70e-08 | 74 |
GO:00108108 | Lung | IAC | regulation of cell-substrate adhesion | 57/2061 | 221/18723 | 5.09e-10 | 1.04e-07 | 57 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TACSTD2 | deletion | Frame_Shift_Del | novel | c.534delG | p.Leu179SerfsTer92 | p.L179Sfs*92 | P09758 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
TACSTD2 | SNV | Missense_Mutation | novel | c.476N>A | p.Arg159His | p.R159H | P09758 | protein_coding | deleterious(0) | probably_damaging(0.94) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TACSTD2 | SNV | Missense_Mutation | novel | c.884T>C | p.Leu295Pro | p.L295P | P09758 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
TACSTD2 | SNV | Missense_Mutation | c.763C>T | p.Arg255Cys | p.R255C | P09758 | protein_coding | deleterious(0) | benign(0.353) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TACSTD2 | SNV | Missense_Mutation | novel | c.745G>A | p.Glu249Lys | p.E249K | P09758 | protein_coding | tolerated(0.12) | benign(0.01) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
TACSTD2 | SNV | Missense_Mutation | novel | c.821C>T | p.Thr274Ile | p.T274I | P09758 | protein_coding | tolerated(0.09) | benign(0.373) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TACSTD2 | SNV | Missense_Mutation | novel | c.334G>A | p.Gly112Ser | p.G112S | P09758 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TACSTD2 | SNV | Missense_Mutation | novel | c.578N>T | p.Ala193Val | p.A193V | P09758 | protein_coding | tolerated(0.08) | possibly_damaging(0.769) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TACSTD2 | SNV | Missense_Mutation | novel | c.908N>T | p.Ser303Leu | p.S303L | P09758 | protein_coding | tolerated(0.1) | benign(0.001) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TACSTD2 | SNV | Missense_Mutation | novel | c.866N>C | p.Val289Ala | p.V289A | P09758 | protein_coding | tolerated(0.73) | benign(0.056) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4070 | TACSTD2 | NA | antibody | 249565933 | ||
4070 | TACSTD2 | NA | N/A |
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