Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/STK3_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/STK3_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/STK3_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/STK3_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/STK3_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/STK3_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/STK3_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/STK3_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/STK3_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/STK3_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/STK3_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/STK3_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00219153 | Colorectum | CRC | neural tube development | 30/2078 | 152/18723 | 1.21e-03 | 1.38e-02 | 30 |
GO:00324114 | Colorectum | CRC | positive regulation of transporter activity | 25/2078 | 120/18723 | 1.37e-03 | 1.50e-02 | 25 |
GO:00018414 | Colorectum | CRC | neural tube formation | 22/2078 | 102/18723 | 1.62e-03 | 1.69e-02 | 22 |
GO:00432701 | Colorectum | CRC | positive regulation of ion transport | 47/2078 | 275/18723 | 1.74e-03 | 1.79e-02 | 47 |
GO:19040621 | Colorectum | CRC | regulation of cation transmembrane transport | 58/2078 | 357/18723 | 1.89e-03 | 1.93e-02 | 58 |
GO:00721753 | Colorectum | CRC | epithelial tube formation | 26/2078 | 132/18723 | 2.56e-03 | 2.40e-02 | 26 |
GO:00347671 | Colorectum | CRC | positive regulation of ion transmembrane transport | 31/2078 | 167/18723 | 2.80e-03 | 2.55e-02 | 31 |
GO:00019335 | Colorectum | CRC | negative regulation of protein phosphorylation | 55/2078 | 342/18723 | 3.05e-03 | 2.72e-02 | 55 |
GO:00459365 | Colorectum | CRC | negative regulation of phosphate metabolic process | 68/2078 | 441/18723 | 3.15e-03 | 2.78e-02 | 68 |
GO:00105635 | Colorectum | CRC | negative regulation of phosphorus metabolic process | 68/2078 | 442/18723 | 3.33e-03 | 2.85e-02 | 68 |
GO:00018383 | Colorectum | CRC | embryonic epithelial tube formation | 24/2078 | 121/18723 | 3.33e-03 | 2.85e-02 | 24 |
GO:00703041 | Colorectum | CRC | positive regulation of stress-activated protein kinase signaling cascade | 25/2078 | 128/18723 | 3.44e-03 | 2.92e-02 | 25 |
GO:1901379 | Colorectum | CRC | regulation of potassium ion transmembrane transport | 20/2078 | 95/18723 | 3.46e-03 | 2.94e-02 | 20 |
GO:0043266 | Colorectum | CRC | regulation of potassium ion transport | 22/2078 | 109/18723 | 3.87e-03 | 3.22e-02 | 22 |
GO:00510513 | Colorectum | CRC | negative regulation of transport | 71/2078 | 470/18723 | 4.33e-03 | 3.47e-02 | 71 |
GO:00336734 | Colorectum | CRC | negative regulation of kinase activity | 40/2078 | 237/18723 | 4.58e-03 | 3.57e-02 | 40 |
GO:00226003 | Colorectum | CRC | digestive system process | 21/2078 | 104/18723 | 4.67e-03 | 3.62e-02 | 21 |
GO:0043410 | Colorectum | CRC | positive regulation of MAPK cascade | 72/2078 | 480/18723 | 4.85e-03 | 3.74e-02 | 72 |
GO:00485683 | Colorectum | CRC | embryonic organ development | 65/2078 | 427/18723 | 5.15e-03 | 3.94e-02 | 65 |
GO:00017014 | Colorectum | CRC | in utero embryonic development | 57/2078 | 367/18723 | 5.54e-03 | 4.19e-02 | 57 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STK3 | SNV | Missense_Mutation | | c.533N>T | p.Gly178Val | p.G178V | Q13188 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A041-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STK3 | SNV | Missense_Mutation | rs545643657 | c.1306N>A | p.Glu436Lys | p.E436K | Q13188 | protein_coding | tolerated(0.62) | benign(0.007) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STK3 | SNV | Missense_Mutation | novel | c.1419N>T | p.Leu473Phe | p.L473F | Q13188 | protein_coding | tolerated(0.63) | benign(0.013) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
STK3 | insertion | Nonsense_Mutation | novel | c.775_776insAGAAATCAG | p.Phe259delinsTer | p.F259delins* | Q13188 | protein_coding | | | TCGA-A7-A26I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
STK3 | insertion | Frame_Shift_Ins | novel | c.1417_1418insCC | p.Leu473SerfsTer2 | p.L473Sfs*2 | Q13188 | protein_coding | | | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
STK3 | insertion | Frame_Shift_Ins | novel | c.719_720insCCTCAGACCAAAGAAG | p.Glu241LeufsTer9 | p.E241Lfs*9 | Q13188 | protein_coding | | | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STK3 | SNV | Missense_Mutation | | c.244N>A | p.Ala82Thr | p.A82T | Q13188 | protein_coding | deleterious(0.02) | probably_damaging(0.981) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
STK3 | SNV | Missense_Mutation | novel | c.541N>T | p.Leu181Phe | p.L181F | Q13188 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-EA-A3Y4-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
STK3 | SNV | Missense_Mutation | | c.721N>C | p.Glu241Gln | p.E241Q | Q13188 | protein_coding | deleterious(0.04) | probably_damaging(0.987) | TCGA-LP-A4AV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
STK3 | SNV | Missense_Mutation | | c.425N>A | p.Arg142Gln | p.R142Q | Q13188 | protein_coding | tolerated(0.06) | possibly_damaging(0.723) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6788 | STK3 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | | SOTRASTAURIN | SOTRASTAURIN | |
6788 | STK3 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | | ALSTERPAULLONE | ALSTERPAULLONE | |
6788 | STK3 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | | SP-600125 | SP-600125 | 23634759 |
6788 | STK3 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | inhibitor | 249565869 | CEP-11981 | |
6788 | STK3 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | | BAY-613606 | CHEMBL541400 | |
6788 | STK3 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | | TAE-684 | TAE-684 | |
6788 | STK3 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | | LAUROGUADINE | LAUROGUADINE | |
6788 | STK3 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | | PF-562271 | PF-00562271 | |
6788 | STK3 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | | GW441756X | GW441756X | |
6788 | STK3 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | | ILORASERTIB | ILORASERTIB | |