Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/SLC25A1_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/SLC25A1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/SLC25A1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/SLC25A1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/SLC25A1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/SLC25A1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/SLC25A1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/SLC25A1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/SLC25A1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00091416 | Liver | Cirrhotic | nucleoside triphosphate metabolic process | 43/4634 | 112/18723 | 9.31e-04 | 6.62e-03 | 43 |
GO:00725225 | Liver | Cirrhotic | purine-containing compound biosynthetic process | 69/4634 | 200/18723 | 1.22e-03 | 8.24e-03 | 69 |
GO:00061645 | Liver | Cirrhotic | purine nucleotide biosynthetic process | 65/4634 | 191/18723 | 2.42e-03 | 1.46e-02 | 65 |
GO:00196271 | Liver | Cirrhotic | urea metabolic process | 8/4634 | 12/18723 | 2.59e-03 | 1.53e-02 | 8 |
GO:00719411 | Liver | Cirrhotic | nitrogen cycle metabolic process | 8/4634 | 12/18723 | 2.59e-03 | 1.53e-02 | 8 |
GO:00091446 | Liver | Cirrhotic | purine nucleoside triphosphate metabolic process | 34/4634 | 88/18723 | 2.68e-03 | 1.57e-02 | 34 |
GO:00091425 | Liver | Cirrhotic | nucleoside triphosphate biosynthetic process | 33/4634 | 85/18723 | 2.81e-03 | 1.63e-02 | 33 |
GO:0033866 | Liver | Cirrhotic | nucleoside bisphosphate biosynthetic process | 25/4634 | 60/18723 | 2.92e-03 | 1.67e-02 | 25 |
GO:0034030 | Liver | Cirrhotic | ribonucleoside bisphosphate biosynthetic process | 25/4634 | 60/18723 | 2.92e-03 | 1.67e-02 | 25 |
GO:0034033 | Liver | Cirrhotic | purine nucleoside bisphosphate biosynthetic process | 25/4634 | 60/18723 | 2.92e-03 | 1.67e-02 | 25 |
GO:00090661 | Liver | Cirrhotic | aspartate family amino acid metabolic process | 21/4634 | 49/18723 | 4.13e-03 | 2.21e-02 | 21 |
GO:00091455 | Liver | Cirrhotic | purine nucleoside triphosphate biosynthetic process | 27/4634 | 69/18723 | 5.74e-03 | 2.88e-02 | 27 |
GO:00092055 | Liver | Cirrhotic | purine ribonucleoside triphosphate metabolic process | 31/4634 | 82/18723 | 5.87e-03 | 2.95e-02 | 31 |
GO:0035384 | Liver | Cirrhotic | thioester biosynthetic process | 19/4634 | 45/18723 | 7.53e-03 | 3.57e-02 | 19 |
GO:0071616 | Liver | Cirrhotic | acyl-CoA biosynthetic process | 19/4634 | 45/18723 | 7.53e-03 | 3.57e-02 | 19 |
GO:00092065 | Liver | Cirrhotic | purine ribonucleoside triphosphate biosynthetic process | 26/4634 | 68/18723 | 9.37e-03 | 4.29e-02 | 26 |
GO:000609122 | Liver | HCC | generation of precursor metabolites and energy | 340/7958 | 490/18723 | 4.04e-34 | 2.85e-31 | 340 |
GO:004533312 | Liver | HCC | cellular respiration | 171/7958 | 230/18723 | 6.35e-23 | 1.26e-20 | 171 |
GO:004603422 | Liver | HCC | ATP metabolic process | 198/7958 | 277/18723 | 8.30e-23 | 1.55e-20 | 198 |
GO:001598022 | Liver | HCC | energy derivation by oxidation of organic compounds | 221/7958 | 318/18723 | 1.02e-22 | 1.86e-20 | 221 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC25A1 | SNV | Missense_Mutation | | c.709N>A | p.Gly237Arg | p.G237R | P53007 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-C8-A27B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
SLC25A1 | SNV | Missense_Mutation | rs782258354 | c.694N>A | p.Ala232Thr | p.A232T | P53007 | protein_coding | deleterious(0.03) | possibly_damaging(0.846) | TCGA-LL-A7SZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
SLC25A1 | insertion | Frame_Shift_Ins | novel | c.226_227insTTACCTTCTCACCTATCAGCTGCTTTTACTTTCAGAATTG | p.Arg76LeufsTer26 | p.R76Lfs*26 | P53007 | protein_coding | | | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD |
SLC25A1 | SNV | Missense_Mutation | | c.358G>A | p.Asp120Asn | p.D120N | P53007 | protein_coding | tolerated(0.27) | benign(0.007) | TCGA-EX-A1H5-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SLC25A1 | SNV | Missense_Mutation | rs431905510 | c.845N>A | p.Arg282His | p.R282H | P53007 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SLC25A1 | SNV | Missense_Mutation | novel | c.593N>A | p.Arg198His | p.R198H | P53007 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC25A1 | SNV | Missense_Mutation | novel | c.631N>A | p.Gly211Arg | p.G211R | P53007 | protein_coding | deleterious(0.02) | benign(0.445) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC25A1 | SNV | Missense_Mutation | novel | c.631N>T | p.Gly211Trp | p.G211W | P53007 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AP-A1DM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC25A1 | SNV | Missense_Mutation | | c.457N>A | p.Asp153Asn | p.D153N | P53007 | protein_coding | deleterious(0.03) | possibly_damaging(0.709) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
SLC25A1 | SNV | Missense_Mutation | novel | c.725N>G | p.Asp242Gly | p.D242G | P53007 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |