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Gene: SET |
Gene summary for SET |
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Gene information | Species | Human | Gene symbol | SET | Gene ID | 6418 |
Gene name | SET nuclear proto-oncogene | |
Gene Alias | 2PP2A | |
Cytomap | 9q34.11 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q01105 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6418 | SET | GSM4909281 | Human | Breast | IDC | 1.19e-12 | 4.38e-01 | 0.21 |
6418 | SET | GSM4909282 | Human | Breast | IDC | 5.84e-06 | 2.65e-01 | -0.0288 |
6418 | SET | GSM4909286 | Human | Breast | IDC | 1.21e-04 | 2.05e-01 | 0.1081 |
6418 | SET | GSM4909288 | Human | Breast | IDC | 4.01e-02 | 8.44e-02 | 0.0988 |
6418 | SET | GSM4909290 | Human | Breast | IDC | 1.06e-06 | 3.80e-01 | 0.2096 |
6418 | SET | GSM4909293 | Human | Breast | IDC | 3.04e-10 | 3.72e-01 | 0.1581 |
6418 | SET | GSM4909294 | Human | Breast | IDC | 1.30e-17 | 2.92e-01 | 0.2022 |
6418 | SET | GSM4909296 | Human | Breast | IDC | 3.02e-15 | -3.98e-01 | 0.1524 |
6418 | SET | GSM4909297 | Human | Breast | IDC | 1.76e-25 | 2.22e-01 | 0.1517 |
6418 | SET | GSM4909306 | Human | Breast | IDC | 7.23e-03 | -2.71e-01 | 0.1564 |
6418 | SET | GSM4909309 | Human | Breast | IDC | 2.00e-02 | -2.24e-01 | 0.0483 |
6418 | SET | GSM4909311 | Human | Breast | IDC | 3.37e-49 | -5.41e-01 | 0.1534 |
6418 | SET | GSM4909312 | Human | Breast | IDC | 1.00e-09 | -2.43e-01 | 0.1552 |
6418 | SET | GSM4909317 | Human | Breast | IDC | 1.36e-02 | 2.79e-01 | 0.1355 |
6418 | SET | GSM4909318 | Human | Breast | IDC | 4.71e-08 | 4.81e-01 | 0.2031 |
6418 | SET | GSM4909319 | Human | Breast | IDC | 1.16e-58 | -8.01e-01 | 0.1563 |
6418 | SET | GSM4909320 | Human | Breast | IDC | 5.01e-11 | -7.26e-01 | 0.1575 |
6418 | SET | GSM4909321 | Human | Breast | IDC | 1.85e-12 | -3.31e-01 | 0.1559 |
6418 | SET | brca10 | Human | Breast | Precancer | 1.12e-11 | -5.22e-01 | -0.0029 |
6418 | SET | M2 | Human | Breast | IDC | 7.97e-12 | 4.74e-01 | 0.21 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00506574 | Colorectum | FAP | nucleic acid transport | 38/2622 | 163/18723 | 9.12e-04 | 9.19e-03 | 38 |
GO:00506584 | Colorectum | FAP | RNA transport | 38/2622 | 163/18723 | 9.12e-04 | 9.19e-03 | 38 |
GO:00063682 | Colorectum | FAP | transcription elongation from RNA polymerase II promoter | 20/2622 | 69/18723 | 9.25e-04 | 9.26e-03 | 20 |
GO:19012153 | Colorectum | FAP | negative regulation of neuron death | 46/2622 | 208/18723 | 9.52e-04 | 9.42e-03 | 46 |
GO:00331203 | Colorectum | FAP | positive regulation of RNA splicing | 13/2622 | 37/18723 | 1.03e-03 | 1.00e-02 | 13 |
GO:00018382 | Colorectum | FAP | embryonic epithelial tube formation | 30/2622 | 121/18723 | 1.08e-03 | 1.05e-02 | 30 |
GO:00721752 | Colorectum | FAP | epithelial tube formation | 32/2622 | 132/18723 | 1.12e-03 | 1.08e-02 | 32 |
GO:00508071 | Colorectum | FAP | regulation of synapse organization | 46/2622 | 211/18723 | 1.30e-03 | 1.20e-02 | 46 |
GO:00063542 | Colorectum | FAP | DNA-templated transcription, elongation | 24/2622 | 91/18723 | 1.32e-03 | 1.22e-02 | 24 |
GO:00606693 | Colorectum | FAP | embryonic placenta morphogenesis | 10/2622 | 26/18723 | 1.77e-03 | 1.53e-02 | 10 |
GO:0048863 | Colorectum | FAP | stem cell differentiation | 44/2622 | 206/18723 | 2.48e-03 | 1.96e-02 | 44 |
GO:0050803 | Colorectum | FAP | regulation of synapse structure or activity | 46/2622 | 218/18723 | 2.59e-03 | 2.03e-02 | 46 |
GO:00069371 | Colorectum | FAP | regulation of muscle contraction | 37/2622 | 169/18723 | 3.39e-03 | 2.47e-02 | 37 |
GO:0006479 | Colorectum | FAP | protein methylation | 39/2622 | 181/18723 | 3.60e-03 | 2.58e-02 | 39 |
GO:0008213 | Colorectum | FAP | protein alkylation | 39/2622 | 181/18723 | 3.60e-03 | 2.58e-02 | 39 |
GO:00018432 | Colorectum | FAP | neural tube closure | 22/2622 | 88/18723 | 4.21e-03 | 2.90e-02 | 22 |
GO:0034968 | Colorectum | FAP | histone lysine methylation | 27/2622 | 115/18723 | 4.23e-03 | 2.90e-02 | 27 |
GO:00432442 | Colorectum | FAP | regulation of protein-containing complex disassembly | 28/2622 | 121/18723 | 4.50e-03 | 3.06e-02 | 28 |
GO:00346144 | Colorectum | FAP | cellular response to reactive oxygen species | 34/2622 | 155/18723 | 4.68e-03 | 3.16e-02 | 34 |
GO:00606062 | Colorectum | FAP | tube closure | 22/2622 | 89/18723 | 4.87e-03 | 3.26e-02 | 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SET | SNV | Missense_Mutation | rs142648600 | c.548N>T | p.Ser183Leu | p.S183L | Q01105 | protein_coding | tolerated(0.16) | benign(0.11) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SET | SNV | Missense_Mutation | novel | c.270N>C | p.Lys90Asn | p.K90N | Q01105 | protein_coding | tolerated(0.05) | benign(0.16) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SET | SNV | Missense_Mutation | c.195N>C | p.Glu65Asp | p.E65D | Q01105 | protein_coding | deleterious(0.01) | possibly_damaging(0.651) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD | |
SET | SNV | Missense_Mutation | novel | c.469N>A | p.His157Asn | p.H157N | Q01105 | protein_coding | tolerated(0.06) | benign(0.208) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
SET | SNV | Missense_Mutation | c.229C>T | p.Arg77Cys | p.R77C | Q01105 | protein_coding | tolerated(0.11) | benign(0.444) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SET | SNV | Missense_Mutation | c.572G>A | p.Ser191Asn | p.S191N | Q01105 | protein_coding | tolerated(0.16) | benign(0.029) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SET | SNV | Missense_Mutation | c.260N>C | p.Leu87Ser | p.L87S | Q01105 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SET | SNV | Missense_Mutation | c.508N>A | p.Glu170Lys | p.E170K | Q01105 | protein_coding | tolerated(0.18) | benign(0.086) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SET | deletion | Frame_Shift_Del | c.273delN | p.Pro92GlnfsTer5 | p.P92Qfs*5 | Q01105 | protein_coding | TCGA-CM-5862-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |||
SET | SNV | Missense_Mutation | novel | c.161N>C | p.Glu54Ala | p.E54A | Q01105 | protein_coding | tolerated(0.06) | possibly_damaging(0.893) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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