Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/RBM3_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/RBM3_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/RBM3_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/RBM3_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/RBM3_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/RBM3_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/RBM3_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/RBM3_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/RBM3_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/RBM3_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/RBM3_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/RBM3_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000039841 | Stomach | SIM | mRNA splicing, via spliceosome | 25/708 | 320/18723 | 5.21e-04 | 8.27e-03 | 25 |
GO:000037541 | Stomach | SIM | RNA splicing, via transesterification reactions | 25/708 | 324/18723 | 6.24e-04 | 9.29e-03 | 25 |
GO:000641751 | Stomach | SIM | regulation of translation | 32/708 | 468/18723 | 9.56e-04 | 1.27e-02 | 32 |
GO:004802631 | Stomach | SIM | positive regulation of mRNA splicing, via spliceosome | 5/708 | 22/18723 | 1.17e-03 | 1.49e-02 | 5 |
GO:003312031 | Stomach | SIM | positive regulation of RNA splicing | 6/708 | 37/18723 | 2.44e-03 | 2.47e-02 | 6 |
GO:004802421 | Stomach | SIM | regulation of mRNA splicing, via spliceosome | 10/708 | 101/18723 | 4.88e-03 | 4.19e-02 | 10 |
GO:004348430 | Thyroid | HT | regulation of RNA splicing | 46/1272 | 148/18723 | 4.82e-19 | 6.71e-16 | 46 |
GO:000838028 | Thyroid | HT | RNA splicing | 84/1272 | 434/18723 | 1.23e-18 | 1.14e-15 | 84 |
GO:000037527 | Thyroid | HT | RNA splicing, via transesterification reactions | 66/1272 | 324/18723 | 4.86e-16 | 2.08e-13 | 66 |
GO:000037727 | Thyroid | HT | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 65/1272 | 320/18723 | 9.43e-16 | 3.50e-13 | 65 |
GO:000039827 | Thyroid | HT | mRNA splicing, via spliceosome | 65/1272 | 320/18723 | 9.43e-16 | 3.50e-13 | 65 |
GO:004802429 | Thyroid | HT | regulation of mRNA splicing, via spliceosome | 34/1272 | 101/18723 | 1.32e-15 | 4.57e-13 | 34 |
GO:005068426 | Thyroid | HT | regulation of mRNA processing | 39/1272 | 137/18723 | 6.30e-15 | 1.95e-12 | 39 |
GO:000641730 | Thyroid | HT | regulation of translation | 78/1272 | 468/18723 | 1.12e-13 | 2.83e-11 | 78 |
GO:190331127 | Thyroid | HT | regulation of mRNA metabolic process | 56/1272 | 288/18723 | 6.33e-13 | 1.47e-10 | 56 |
GO:003425027 | Thyroid | HT | positive regulation of cellular amide metabolic process | 35/1272 | 162/18723 | 7.30e-10 | 8.12e-08 | 35 |
GO:004572727 | Thyroid | HT | positive regulation of translation | 31/1272 | 136/18723 | 1.71e-09 | 1.78e-07 | 31 |
GO:003312026 | Thyroid | HT | positive regulation of RNA splicing | 13/1272 | 37/18723 | 4.72e-07 | 2.07e-05 | 13 |
GO:004802620 | Thyroid | HT | positive regulation of mRNA splicing, via spliceosome | 8/1272 | 22/18723 | 6.00e-05 | 1.13e-03 | 8 |
GO:00506857 | Thyroid | HT | positive regulation of mRNA processing | 8/1272 | 32/18723 | 1.07e-03 | 1.08e-02 | 8 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RBM3 | SNV | Missense_Mutation | | c.185N>A | p.Val62Asp | p.V62D | P98179 | protein_coding | tolerated(1) | benign(0) | TCGA-E9-A1R2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | CR |
RBM3 | SNV | Missense_Mutation | | c.287N>T | p.Ala96Val | p.A96V | P98179 | protein_coding | tolerated(0.08) | benign(0.003) | TCGA-EK-A2H1-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cetuximab | SD |
RBM3 | SNV | Missense_Mutation | novel | c.269N>C | p.Arg90Thr | p.R90T | P98179 | protein_coding | deleterious(0.01) | possibly_damaging(0.587) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RBM3 | SNV | Missense_Mutation | rs782287047 | c.295N>T | p.Arg99Cys | p.R99C | P98179 | protein_coding | tolerated(0.14) | benign(0) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RBM3 | SNV | Missense_Mutation | novel | c.42N>A | p.Asn14Lys | p.N14K | P98179 | protein_coding | deleterious(0.01) | possibly_damaging(0.9) | TCGA-A5-A1OG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | PD |
RBM3 | SNV | Missense_Mutation | novel | c.392N>A | p.Arg131His | p.R131H | P98179 | protein_coding | tolerated(0.27) | benign(0.078) | TCGA-AJ-A8CW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RBM3 | SNV | Missense_Mutation | novel | c.305N>T | p.Ser102Ile | p.S102I | P98179 | protein_coding | deleterious(0.02) | benign(0) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RBM3 | SNV | Missense_Mutation | | c.113T>G | p.Val38Gly | p.V38G | P98179 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RBM3 | SNV | Missense_Mutation | | c.284N>A | p.Gly95Glu | p.G95E | P98179 | protein_coding | tolerated(0.28) | possibly_damaging(0.604) | TCGA-D1-A17F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RBM3 | SNV | Missense_Mutation | novel | c.88N>A | p.Gly30Arg | p.G30R | P98179 | protein_coding | tolerated(0.11) | possibly_damaging(0.729) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |