Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/PUM2_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/PUM2_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/PUM2_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/PUM2_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/PUM2_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/PUM2_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/PUM2_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/PUM2_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/PUM2_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/PUM2_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00622075 | Prostate | Tumor | regulation of pattern recognition receptor signaling pathway | 28/3246 | 105/18723 | 1.08e-02 | 4.47e-02 | 28 |
GO:00027536 | Prostate | Tumor | cytoplasmic pattern recognition receptor signaling pathway | 18/3246 | 60/18723 | 1.10e-02 | 4.55e-02 | 18 |
GO:190331125 | Skin | AK | regulation of mRNA metabolic process | 81/1910 | 288/18723 | 7.27e-18 | 8.61e-15 | 81 |
GO:000641728 | Skin | AK | regulation of translation | 102/1910 | 468/18723 | 6.79e-14 | 2.36e-11 | 102 |
GO:000640225 | Skin | AK | mRNA catabolic process | 56/1910 | 232/18723 | 6.06e-10 | 6.41e-08 | 56 |
GO:006101320 | Skin | AK | regulation of mRNA catabolic process | 42/1910 | 166/18723 | 1.94e-08 | 1.15e-06 | 42 |
GO:004348820 | Skin | AK | regulation of mRNA stability | 40/1910 | 158/18723 | 4.12e-08 | 2.14e-06 | 40 |
GO:000640125 | Skin | AK | RNA catabolic process | 58/1910 | 278/18723 | 8.82e-08 | 4.08e-06 | 58 |
GO:003052226 | Skin | AK | intracellular receptor signaling pathway | 55/1910 | 265/18723 | 2.26e-07 | 9.03e-06 | 55 |
GO:004348720 | Skin | AK | regulation of RNA stability | 40/1910 | 170/18723 | 3.43e-07 | 1.33e-05 | 40 |
GO:003519610 | Skin | AK | production of miRNAs involved in gene silencing by miRNA | 18/1910 | 52/18723 | 1.88e-06 | 5.54e-05 | 18 |
GO:006096415 | Skin | AK | regulation of gene silencing by miRNA | 17/1910 | 49/18723 | 3.49e-06 | 8.86e-05 | 17 |
GO:00310509 | Skin | AK | dsRNA processing | 18/1910 | 54/18723 | 3.50e-06 | 8.86e-05 | 18 |
GO:00709189 | Skin | AK | production of small RNA involved in gene silencing by RNA | 18/1910 | 54/18723 | 3.50e-06 | 8.86e-05 | 18 |
GO:00321038 | Skin | AK | positive regulation of response to external stimulus | 74/1910 | 427/18723 | 3.63e-06 | 9.07e-05 | 74 |
GO:006014710 | Skin | AK | regulation of posttranscriptional gene silencing | 17/1910 | 52/18723 | 8.76e-06 | 1.89e-04 | 17 |
GO:00609668 | Skin | AK | regulation of gene silencing by RNA | 17/1910 | 53/18723 | 1.17e-05 | 2.42e-04 | 17 |
GO:20006378 | Skin | AK | positive regulation of gene silencing by miRNA | 12/1910 | 30/18723 | 1.83e-05 | 3.47e-04 | 12 |
GO:000961519 | Skin | AK | response to virus | 63/1910 | 367/18723 | 2.53e-05 | 4.54e-04 | 63 |
GO:00601488 | Skin | AK | positive regulation of posttranscriptional gene silencing | 12/1910 | 31/18723 | 2.71e-05 | 4.77e-04 | 12 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PUM2 | SNV | Missense_Mutation | | c.2534A>C | p.Asp845Ala | p.D845A | Q8TB72 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-A2-A04Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
PUM2 | SNV | Missense_Mutation | | c.1364N>G | p.Thr455Ser | p.T455S | Q8TB72 | protein_coding | tolerated(0.26) | benign(0.041) | TCGA-A2-A0D2-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
PUM2 | SNV | Missense_Mutation | rs372196772 | c.536N>A | p.Arg179His | p.R179H | Q8TB72 | protein_coding | tolerated(0.15) | possibly_damaging(0.796) | TCGA-A8-A07W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | exemestane | SD |
PUM2 | SNV | Missense_Mutation | | c.308N>T | p.Pro103Leu | p.P103L | Q8TB72 | protein_coding | deleterious_low_confidence(0) | probably_damaging(1) | TCGA-AR-A24H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
PUM2 | SNV | Missense_Mutation | rs761103124 | c.502G>A | p.Asp168Asn | p.D168N | Q8TB72 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD |
PUM2 | SNV | Missense_Mutation | | c.562N>A | p.Glu188Lys | p.E188K | Q8TB72 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.465) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
PUM2 | SNV | Missense_Mutation | | c.2147A>G | p.Asn716Ser | p.N716S | Q8TB72 | protein_coding | tolerated(0.13) | benign(0.194) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PUM2 | SNV | Missense_Mutation | | c.364N>A | p.Glu122Lys | p.E122K | Q8TB72 | protein_coding | tolerated_low_confidence(0.22) | possibly_damaging(0.465) | TCGA-C8-A12Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
PUM2 | insertion | Nonsense_Mutation | novel | c.1525_1526insTATTGTTTCTTATGTTTTTTTTATGA | p.Gln509LeufsTer9 | p.Q509Lfs*9 | Q8TB72 | protein_coding | | | TCGA-A2-A0EM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
PUM2 | deletion | Frame_Shift_Del | novel | c.2019delT | p.Arg674GlufsTer54 | p.R674Efs*54 | Q8TB72 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |