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Gene: PTTG1 |
Gene summary for PTTG1 |
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Gene information | Species | Human | Gene symbol | PTTG1 | Gene ID | 9232 |
Gene name | PTTG1 regulator of sister chromatid separation, securin | |
Gene Alias | EAP1 | |
Cytomap | 5q33.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | O95997 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9232 | PTTG1 | GSM4909281 | Human | Breast | IDC | 4.73e-09 | 4.09e-01 | 0.21 |
9232 | PTTG1 | GSM4909282 | Human | Breast | IDC | 1.51e-30 | 6.71e-01 | -0.0288 |
9232 | PTTG1 | GSM4909285 | Human | Breast | IDC | 1.11e-16 | 4.70e-01 | 0.21 |
9232 | PTTG1 | GSM4909287 | Human | Breast | IDC | 3.85e-08 | 4.19e-01 | 0.2057 |
9232 | PTTG1 | GSM4909311 | Human | Breast | IDC | 3.11e-02 | -1.12e-01 | 0.1534 |
9232 | PTTG1 | GSM4909319 | Human | Breast | IDC | 1.35e-06 | 6.14e-02 | 0.1563 |
9232 | PTTG1 | M2 | Human | Breast | IDC | 1.92e-02 | 3.59e-01 | 0.21 |
9232 | PTTG1 | NCCBC5 | Human | Breast | DCIS | 5.07e-04 | 3.19e-01 | 0.2046 |
9232 | PTTG1 | P1 | Human | Breast | IDC | 8.01e-05 | 2.28e-01 | 0.1527 |
9232 | PTTG1 | P2 | Human | Breast | IDC | 8.53e-03 | 2.73e-01 | 0.21 |
9232 | PTTG1 | LZE2T | Human | Esophagus | ESCC | 1.01e-05 | 1.68e+00 | 0.082 |
9232 | PTTG1 | LZE4T | Human | Esophagus | ESCC | 2.71e-08 | 6.88e-01 | 0.0811 |
9232 | PTTG1 | LZE7T | Human | Esophagus | ESCC | 4.27e-02 | 4.34e-01 | 0.0667 |
9232 | PTTG1 | LZE20T | Human | Esophagus | ESCC | 3.28e-03 | 6.01e-01 | 0.0662 |
9232 | PTTG1 | LZE22D1 | Human | Esophagus | HGIN | 6.50e-05 | 1.94e-01 | 0.0595 |
9232 | PTTG1 | LZE6T | Human | Esophagus | ESCC | 9.30e-20 | 1.51e+00 | 0.0845 |
9232 | PTTG1 | P2T-E | Human | Esophagus | ESCC | 3.51e-22 | 1.48e+00 | 0.1177 |
9232 | PTTG1 | P4T-E | Human | Esophagus | ESCC | 2.70e-38 | 1.67e+00 | 0.1323 |
9232 | PTTG1 | P5T-E | Human | Esophagus | ESCC | 2.19e-62 | 2.12e+00 | 0.1327 |
9232 | PTTG1 | P9T-E | Human | Esophagus | ESCC | 2.15e-25 | 1.44e+00 | 0.1131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00457864 | Oral cavity | OSCC | negative regulation of cell cycle | 206/7305 | 385/18723 | 4.28e-09 | 9.55e-08 | 206 |
GO:00427707 | Oral cavity | OSCC | signal transduction in response to DNA damage | 102/7305 | 172/18723 | 5.27e-08 | 9.68e-07 | 102 |
GO:190179620 | Oral cavity | OSCC | regulation of signal transduction by p53 class mediator | 62/7305 | 93/18723 | 5.99e-08 | 1.09e-06 | 62 |
GO:00313986 | Oral cavity | OSCC | positive regulation of protein ubiquitination | 75/7305 | 119/18723 | 9.46e-08 | 1.65e-06 | 75 |
GO:004586120 | Oral cavity | OSCC | negative regulation of proteolysis | 181/7305 | 351/18723 | 1.01e-06 | 1.37e-05 | 181 |
GO:00109483 | Oral cavity | OSCC | negative regulation of cell cycle process | 155/7305 | 294/18723 | 1.11e-06 | 1.48e-05 | 155 |
GO:00519832 | Oral cavity | OSCC | regulation of chromosome segregation | 58/7305 | 91/18723 | 1.54e-06 | 2.03e-05 | 58 |
GO:00513061 | Oral cavity | OSCC | mitotic sister chromatid separation | 45/7305 | 67/18723 | 2.82e-06 | 3.47e-05 | 45 |
GO:00330451 | Oral cavity | OSCC | regulation of sister chromatid segregation | 47/7305 | 72/18723 | 5.69e-06 | 6.33e-05 | 47 |
GO:19058181 | Oral cavity | OSCC | regulation of chromosome separation | 47/7305 | 72/18723 | 5.69e-06 | 6.33e-05 | 47 |
GO:00109651 | Oral cavity | OSCC | regulation of mitotic sister chromatid separation | 43/7305 | 65/18723 | 8.50e-06 | 9.06e-05 | 43 |
GO:003033018 | Oral cavity | OSCC | DNA damage response, signal transduction by p53 class mediator | 46/7305 | 72/18723 | 1.66e-05 | 1.64e-04 | 46 |
GO:20012512 | Oral cavity | OSCC | negative regulation of chromosome organization | 52/7305 | 86/18723 | 4.50e-05 | 3.84e-04 | 52 |
GO:190225318 | Oral cavity | OSCC | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 22/7305 | 29/18723 | 6.05e-05 | 4.95e-04 | 22 |
GO:20010213 | Oral cavity | OSCC | negative regulation of response to DNA damage stimulus | 49/7305 | 81/18723 | 7.27e-05 | 5.72e-04 | 49 |
GO:005134618 | Oral cavity | OSCC | negative regulation of hydrolase activity | 182/7305 | 379/18723 | 1.98e-04 | 1.32e-03 | 182 |
GO:001095117 | Oral cavity | OSCC | negative regulation of endopeptidase activity | 126/7305 | 252/18723 | 2.37e-04 | 1.54e-03 | 126 |
GO:001046618 | Oral cavity | OSCC | negative regulation of peptidase activity | 130/7305 | 262/18723 | 2.89e-04 | 1.82e-03 | 130 |
GO:00330471 | Oral cavity | OSCC | regulation of mitotic sister chromatid segregation | 29/7305 | 46/18723 | 8.26e-04 | 4.38e-03 | 29 |
GO:00513041 | Oral cavity | OSCC | chromosome separation | 53/7305 | 96/18723 | 9.24e-04 | 4.86e-03 | 53 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0516624 | Breast | IDC | Human T-cell leukemia virus 1 infection | 40/867 | 222/8465 | 2.52e-04 | 2.21e-03 | 1.66e-03 | 40 |
hsa0516634 | Breast | IDC | Human T-cell leukemia virus 1 infection | 40/867 | 222/8465 | 2.52e-04 | 2.21e-03 | 1.66e-03 | 40 |
hsa0516642 | Breast | DCIS | Human T-cell leukemia virus 1 infection | 41/846 | 222/8465 | 7.03e-05 | 6.88e-04 | 5.07e-04 | 41 |
hsa0516652 | Breast | DCIS | Human T-cell leukemia virus 1 infection | 41/846 | 222/8465 | 7.03e-05 | 6.88e-04 | 5.07e-04 | 41 |
hsa0516639 | Esophagus | HGIN | Human T-cell leukemia virus 1 infection | 51/1383 | 222/8465 | 5.84e-03 | 4.05e-02 | 3.22e-02 | 51 |
hsa041109 | Esophagus | HGIN | Cell cycle | 38/1383 | 157/8465 | 6.70e-03 | 4.37e-02 | 3.47e-02 | 38 |
hsa05166114 | Esophagus | HGIN | Human T-cell leukemia virus 1 infection | 51/1383 | 222/8465 | 5.84e-03 | 4.05e-02 | 3.22e-02 | 51 |
hsa0411016 | Esophagus | HGIN | Cell cycle | 38/1383 | 157/8465 | 6.70e-03 | 4.37e-02 | 3.47e-02 | 38 |
hsa0411023 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa05166211 | Esophagus | ESCC | Human T-cell leukemia virus 1 infection | 164/4205 | 222/8465 | 8.13e-14 | 2.09e-12 | 1.07e-12 | 164 |
hsa041146 | Esophagus | ESCC | Oocyte meiosis | 77/4205 | 131/8465 | 2.19e-02 | 4.80e-02 | 2.46e-02 | 77 |
hsa0411033 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa05166310 | Esophagus | ESCC | Human T-cell leukemia virus 1 infection | 164/4205 | 222/8465 | 8.13e-14 | 2.09e-12 | 1.07e-12 | 164 |
hsa0411411 | Esophagus | ESCC | Oocyte meiosis | 77/4205 | 131/8465 | 2.19e-02 | 4.80e-02 | 2.46e-02 | 77 |
hsa041102 | Liver | HCC | Cell cycle | 106/4020 | 157/8465 | 2.54e-07 | 3.04e-06 | 1.69e-06 | 106 |
hsa0516622 | Liver | HCC | Human T-cell leukemia virus 1 infection | 139/4020 | 222/8465 | 3.17e-06 | 2.79e-05 | 1.55e-05 | 139 |
hsa041103 | Liver | HCC | Cell cycle | 106/4020 | 157/8465 | 2.54e-07 | 3.04e-06 | 1.69e-06 | 106 |
hsa0516632 | Liver | HCC | Human T-cell leukemia virus 1 infection | 139/4020 | 222/8465 | 3.17e-06 | 2.79e-05 | 1.55e-05 | 139 |
hsa041108 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
hsa0516630 | Oral cavity | OSCC | Human T-cell leukemia virus 1 infection | 150/3704 | 222/8465 | 3.68e-13 | 7.26e-12 | 3.70e-12 | 150 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTTG1 | SNV | Missense_Mutation | c.385N>A | p.Asp129Asn | p.D129N | O95997 | protein_coding | deleterious(0.03) | benign(0.125) | TCGA-BH-A204-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PTTG1 | SNV | Missense_Mutation | rs763093561 | c.351N>A | p.Phe117Leu | p.F117L | O95997 | protein_coding | tolerated(0.5) | benign(0.007) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
PTTG1 | SNV | Missense_Mutation | novel | c.491C>A | p.Pro164His | p.P164H | O95997 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PTTG1 | SNV | Missense_Mutation | novel | c.551N>A | p.Ser184Asn | p.S184N | O95997 | protein_coding | tolerated(0.31) | possibly_damaging(0.459) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
PTTG1 | SNV | Missense_Mutation | c.329N>T | p.Ala110Val | p.A110V | O95997 | protein_coding | tolerated(0.2) | benign(0.171) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD | |
PTTG1 | SNV | Missense_Mutation | c.385N>A | p.Asp129Asn | p.D129N | O95997 | protein_coding | deleterious(0.03) | benign(0.125) | TCGA-B5-A11U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PTTG1 | SNV | Missense_Mutation | novel | c.391C>T | p.Pro131Ser | p.P131S | O95997 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTTG1 | SNV | Missense_Mutation | novel | c.584N>T | p.Pro195Leu | p.P195L | O95997 | protein_coding | deleterious(0) | possibly_damaging(0.661) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTTG1 | SNV | Missense_Mutation | novel | c.583N>A | p.Pro195Thr | p.P195T | O95997 | protein_coding | deleterious(0) | possibly_damaging(0.661) | TCGA-DD-AAC9-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PTTG1 | SNV | Missense_Mutation | c.410C>G | p.Ala137Gly | p.A137G | O95997 | protein_coding | deleterious(0.02) | possibly_damaging(0.715) | TCGA-05-4427-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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