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Gene: NDUFB10 |
Gene summary for NDUFB10 |
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Gene information | Species | Human | Gene symbol | NDUFB10 | Gene ID | 4716 |
Gene name | NADH:ubiquinone oxidoreductase subunit B10 | |
Gene Alias | MC1DN35 | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | A8K761 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4716 | NDUFB10 | GSM4909286 | Human | Breast | IDC | 1.71e-03 | -2.50e-01 | 0.1081 |
4716 | NDUFB10 | GSM4909287 | Human | Breast | IDC | 2.33e-08 | 4.03e-01 | 0.2057 |
4716 | NDUFB10 | GSM4909291 | Human | Breast | IDC | 2.09e-03 | 3.44e-01 | 0.1753 |
4716 | NDUFB10 | GSM4909293 | Human | Breast | IDC | 1.03e-12 | 4.15e-01 | 0.1581 |
4716 | NDUFB10 | GSM4909294 | Human | Breast | IDC | 5.45e-16 | 3.29e-01 | 0.2022 |
4716 | NDUFB10 | GSM4909296 | Human | Breast | IDC | 4.45e-12 | 1.08e-01 | 0.1524 |
4716 | NDUFB10 | GSM4909297 | Human | Breast | IDC | 1.08e-16 | 9.37e-03 | 0.1517 |
4716 | NDUFB10 | GSM4909298 | Human | Breast | IDC | 6.65e-10 | 4.06e-01 | 0.1551 |
4716 | NDUFB10 | GSM4909301 | Human | Breast | IDC | 2.60e-10 | 3.04e-01 | 0.1577 |
4716 | NDUFB10 | GSM4909302 | Human | Breast | IDC | 2.67e-03 | 2.35e-01 | 0.1545 |
4716 | NDUFB10 | GSM4909304 | Human | Breast | IDC | 7.28e-28 | 5.62e-01 | 0.1636 |
4716 | NDUFB10 | GSM4909305 | Human | Breast | IDC | 7.77e-03 | 3.05e-01 | 0.0436 |
4716 | NDUFB10 | GSM4909306 | Human | Breast | IDC | 3.90e-40 | 7.09e-01 | 0.1564 |
4716 | NDUFB10 | GSM4909307 | Human | Breast | IDC | 5.59e-15 | 4.24e-01 | 0.1569 |
4716 | NDUFB10 | GSM4909308 | Human | Breast | IDC | 4.76e-19 | 5.26e-01 | 0.158 |
4716 | NDUFB10 | GSM4909311 | Human | Breast | IDC | 7.51e-42 | -1.48e-01 | 0.1534 |
4716 | NDUFB10 | GSM4909312 | Human | Breast | IDC | 4.61e-10 | -2.82e-02 | 0.1552 |
4716 | NDUFB10 | GSM4909313 | Human | Breast | IDC | 1.24e-02 | 1.66e-01 | 0.0391 |
4716 | NDUFB10 | GSM4909317 | Human | Breast | IDC | 4.64e-16 | 5.20e-01 | 0.1355 |
4716 | NDUFB10 | GSM4909318 | Human | Breast | IDC | 1.18e-13 | 6.45e-01 | 0.2031 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003298132 | Thyroid | ATC | mitochondrial respiratory chain complex I assembly | 43/6293 | 57/18723 | 1.20e-10 | 3.75e-09 | 43 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501218 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502016 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501616 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019016 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501016 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501416 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520818 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471418 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541518 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
hsa0493216 | Breast | Precancer | Non-alcoholic fatty liver disease | 48/684 | 155/8465 | 6.16e-17 | 1.50e-15 | 1.15e-15 | 48 |
hsa0472316 | Breast | Precancer | Retrograde endocannabinoid signaling | 25/684 | 148/8465 | 3.05e-04 | 2.47e-03 | 1.89e-03 | 25 |
hsa0501219 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502017 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501617 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019017 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501017 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501417 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520819 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NDUFB10 | SNV | Missense_Mutation | novel | c.94N>A | p.Asp32Asn | p.D32N | O96000 | protein_coding | tolerated(0.43) | benign(0.001) | TCGA-BH-A42V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NDUFB10 | SNV | Missense_Mutation | c.385G>A | p.Val129Met | p.V129M | O96000 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
NDUFB10 | SNV | Missense_Mutation | c.81G>A | p.Met27Ile | p.M27I | O96000 | protein_coding | tolerated(0.44) | benign(0) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
NDUFB10 | deletion | Frame_Shift_Del | c.84delG | p.Met28IlefsTer12 | p.M28Ifs*12 | O96000 | protein_coding | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |||
NDUFB10 | SNV | Missense_Mutation | c.461N>A | p.Arg154Lys | p.R154K | O96000 | protein_coding | tolerated(1) | benign(0) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NDUFB10 | SNV | Missense_Mutation | novel | c.163N>C | p.Tyr55His | p.Y55H | O96000 | protein_coding | tolerated(0.09) | possibly_damaging(0.83) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NDUFB10 | SNV | Missense_Mutation | c.295N>G | p.Ile99Val | p.I99V | O96000 | protein_coding | tolerated(0.24) | benign(0.062) | TCGA-CK-6748-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
NDUFB10 | SNV | Missense_Mutation | c.211N>C | p.Cys71Arg | p.C71R | O96000 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NDUFB10 | SNV | Missense_Mutation | rs149920175 | c.191G>A | p.Arg64His | p.R64H | O96000 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-AJ-A3NE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NDUFB10 | SNV | Missense_Mutation | rs140580390 | c.277G>A | p.Asp93Asn | p.D93N | O96000 | protein_coding | deleterious(0.05) | probably_damaging(0.999) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4716 | NDUFB10 | ENZYME | inhibitor | CHEMBL3545320 | ME-344 | |
4716 | NDUFB10 | ENZYME | inhibitor | CHEMBL1703 | METFORMIN HYDROCHLORIDE | |
4716 | NDUFB10 | ENZYME | inhibitor | CHEMBL3545135 | NV-128 |
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