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Gene: DAPK3 |
Gene summary for DAPK3 |
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Gene information | Species | Human | Gene symbol | DAPK3 | Gene ID | 1613 |
Gene name | death associated protein kinase 3 | |
Gene Alias | DLK | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | B3KNJ3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1613 | DAPK3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.34e-22 | 6.15e-01 | 0.0155 |
1613 | DAPK3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 9.27e-18 | 6.49e-01 | -0.1808 |
1613 | DAPK3 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.91e-08 | 8.20e-01 | 0.0216 |
1613 | DAPK3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.08e-35 | 1.05e+00 | -0.0811 |
1613 | DAPK3 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.13e-02 | 2.80e-01 | -0.1088 |
1613 | DAPK3 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.11e-18 | 5.44e-01 | -0.1954 |
1613 | DAPK3 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.77e-07 | 1.06e+00 | -0.2602 |
1613 | DAPK3 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.67e-05 | 6.83e-01 | -0.2196 |
1613 | DAPK3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.21e-22 | 8.03e-01 | -0.1207 |
1613 | DAPK3 | HTA11_83_2000001011 | Human | Colorectum | SER | 8.85e-14 | 6.70e-01 | -0.1526 |
1613 | DAPK3 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.16e-50 | 1.18e+00 | -0.1464 |
1613 | DAPK3 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.72e-20 | 5.49e-01 | -0.1001 |
1613 | DAPK3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.52e-32 | 9.51e-01 | -0.059 |
1613 | DAPK3 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.71e-14 | 9.23e-01 | -0.1706 |
1613 | DAPK3 | HTA11_5212_2000001011 | Human | Colorectum | AD | 9.40e-11 | 7.01e-01 | -0.2061 |
1613 | DAPK3 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.33e-24 | 1.56e+00 | -0.1462 |
1613 | DAPK3 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.90e-15 | 7.58e-01 | -0.0842 |
1613 | DAPK3 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.77e-03 | 2.69e-01 | 0.096 |
1613 | DAPK3 | HTA11_7663_2000001011 | Human | Colorectum | SER | 6.52e-03 | 4.93e-01 | 0.0131 |
1613 | DAPK3 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.84e-02 | 2.54e-01 | 0.0338 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003297029 | Skin | cSCC | regulation of actin filament-based process | 142/4864 | 397/18723 | 8.50e-06 | 1.13e-04 | 142 |
GO:002260427 | Skin | cSCC | regulation of cell morphogenesis | 114/4864 | 309/18723 | 1.34e-05 | 1.68e-04 | 114 |
GO:004804124 | Skin | cSCC | focal adhesion assembly | 41/4864 | 87/18723 | 1.71e-05 | 2.07e-04 | 41 |
GO:003158926 | Skin | cSCC | cell-substrate adhesion | 130/4864 | 363/18723 | 1.87e-05 | 2.23e-04 | 130 |
GO:001714814 | Skin | cSCC | negative regulation of translation | 93/4864 | 245/18723 | 2.28e-05 | 2.63e-04 | 93 |
GO:003295629 | Skin | cSCC | regulation of actin cytoskeleton organization | 127/4864 | 358/18723 | 3.83e-05 | 4.13e-04 | 127 |
GO:003011124 | Skin | cSCC | regulation of Wnt signaling pathway | 117/4864 | 328/18723 | 5.80e-05 | 5.75e-04 | 117 |
GO:003434115 | Skin | cSCC | response to interferon-gamma | 57/4864 | 141/18723 | 1.20e-04 | 1.11e-03 | 57 |
GO:004677715 | Skin | cSCC | protein autophosphorylation | 84/4864 | 227/18723 | 1.53e-04 | 1.35e-03 | 84 |
GO:009026324 | Skin | cSCC | positive regulation of canonical Wnt signaling pathway | 45/4864 | 106/18723 | 1.61e-04 | 1.42e-03 | 45 |
GO:000716024 | Skin | cSCC | cell-matrix adhesion | 85/4864 | 233/18723 | 2.43e-04 | 1.98e-03 | 85 |
GO:003017724 | Skin | cSCC | positive regulation of Wnt signaling pathway | 55/4864 | 140/18723 | 3.72e-04 | 2.92e-03 | 55 |
GO:007134613 | Skin | cSCC | cellular response to interferon-gamma | 47/4864 | 118/18723 | 6.71e-04 | 4.79e-03 | 47 |
GO:006007024 | Skin | cSCC | canonical Wnt signaling pathway | 104/4864 | 303/18723 | 7.13e-04 | 5.03e-03 | 104 |
GO:000836025 | Skin | cSCC | regulation of cell shape | 57/4864 | 154/18723 | 1.61e-03 | 9.90e-03 | 57 |
GO:006082824 | Skin | cSCC | regulation of canonical Wnt signaling pathway | 87/4864 | 253/18723 | 1.74e-03 | 1.06e-02 | 87 |
GO:003153224 | Skin | cSCC | actin cytoskeleton reorganization | 42/4864 | 107/18723 | 1.76e-03 | 1.07e-02 | 42 |
GO:2001233113 | Thyroid | PTC | regulation of apoptotic signaling pathway | 197/5968 | 356/18723 | 2.58e-20 | 3.69e-18 | 197 |
GO:1902903113 | Thyroid | PTC | regulation of supramolecular fiber organization | 202/5968 | 383/18723 | 1.16e-17 | 1.15e-15 | 202 |
GO:0006417113 | Thyroid | PTC | regulation of translation | 236/5968 | 468/18723 | 2.70e-17 | 2.52e-15 | 236 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04140 | Colorectum | AD | Autophagy - animal | 49/2092 | 141/8465 | 4.58e-03 | 2.20e-02 | 1.40e-02 | 49 |
hsa041401 | Colorectum | AD | Autophagy - animal | 49/2092 | 141/8465 | 4.58e-03 | 2.20e-02 | 1.40e-02 | 49 |
hsa041402 | Colorectum | SER | Autophagy - animal | 39/1580 | 141/8465 | 5.43e-03 | 3.28e-02 | 2.38e-02 | 39 |
hsa041403 | Colorectum | SER | Autophagy - animal | 39/1580 | 141/8465 | 5.43e-03 | 3.28e-02 | 2.38e-02 | 39 |
hsa041404 | Colorectum | MSS | Autophagy - animal | 45/1875 | 141/8465 | 4.42e-03 | 1.90e-02 | 1.16e-02 | 45 |
hsa041405 | Colorectum | MSS | Autophagy - animal | 45/1875 | 141/8465 | 4.42e-03 | 1.90e-02 | 1.16e-02 | 45 |
hsa0414010 | Esophagus | ESCC | Autophagy - animal | 101/4205 | 141/8465 | 7.60e-08 | 6.21e-07 | 3.18e-07 | 101 |
hsa0521910 | Esophagus | ESCC | Bladder cancer | 35/4205 | 41/8465 | 1.91e-06 | 1.15e-05 | 5.87e-06 | 35 |
hsa0414015 | Esophagus | ESCC | Autophagy - animal | 101/4205 | 141/8465 | 7.60e-08 | 6.21e-07 | 3.18e-07 | 101 |
hsa0521917 | Esophagus | ESCC | Bladder cancer | 35/4205 | 41/8465 | 1.91e-06 | 1.15e-05 | 5.87e-06 | 35 |
hsa041406 | Liver | Cirrhotic | Autophagy - animal | 65/2530 | 141/8465 | 3.10e-05 | 2.47e-04 | 1.52e-04 | 65 |
hsa052194 | Liver | Cirrhotic | Bladder cancer | 25/2530 | 41/8465 | 3.48e-05 | 2.57e-04 | 1.59e-04 | 25 |
hsa0414011 | Liver | Cirrhotic | Autophagy - animal | 65/2530 | 141/8465 | 3.10e-05 | 2.47e-04 | 1.52e-04 | 65 |
hsa0521911 | Liver | Cirrhotic | Bladder cancer | 25/2530 | 41/8465 | 3.48e-05 | 2.57e-04 | 1.59e-04 | 25 |
hsa0414021 | Liver | HCC | Autophagy - animal | 99/4020 | 141/8465 | 3.08e-08 | 4.70e-07 | 2.61e-07 | 99 |
hsa052192 | Liver | HCC | Bladder cancer | 30/4020 | 41/8465 | 7.37e-04 | 2.94e-03 | 1.63e-03 | 30 |
hsa0414031 | Liver | HCC | Autophagy - animal | 99/4020 | 141/8465 | 3.08e-08 | 4.70e-07 | 2.61e-07 | 99 |
hsa052193 | Liver | HCC | Bladder cancer | 30/4020 | 41/8465 | 7.37e-04 | 2.94e-03 | 1.63e-03 | 30 |
hsa052195 | Lung | IAC | Bladder cancer | 13/1053 | 41/8465 | 9.74e-04 | 7.32e-03 | 4.86e-03 | 13 |
hsa041407 | Lung | IAC | Autophagy - animal | 28/1053 | 141/8465 | 7.64e-03 | 3.03e-02 | 2.01e-02 | 28 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DAPK3 | SNV | Missense_Mutation | novel | c.703N>A | p.Asp235Asn | p.D235N | O43293 | protein_coding | tolerated(0.07) | benign(0.062) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
DAPK3 | SNV | Missense_Mutation | novel | c.522C>G | p.Phe174Leu | p.F174L | O43293 | protein_coding | tolerated(0.19) | benign(0.047) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
DAPK3 | SNV | Missense_Mutation | novel | c.531C>G | p.Ile177Met | p.I177M | O43293 | protein_coding | tolerated(0.18) | benign(0.323) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
DAPK3 | SNV | Missense_Mutation | c.988G>C | p.Glu330Gln | p.E330Q | O43293 | protein_coding | deleterious(0.02) | benign(0.417) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
DAPK3 | SNV | Missense_Mutation | rs547931912 | c.785N>A | p.Arg262Gln | p.R262Q | O43293 | protein_coding | deleterious(0.05) | benign(0.012) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DAPK3 | SNV | Missense_Mutation | c.527N>T | p.Asn176Ile | p.N176I | O43293 | protein_coding | deleterious(0) | possibly_damaging(0.887) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
DAPK3 | SNV | Missense_Mutation | c.493N>A | p.Ala165Thr | p.A165T | O43293 | protein_coding | deleterious(0) | possibly_damaging(0.901) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DAPK3 | SNV | Missense_Mutation | c.146N>C | p.Leu49Pro | p.L49P | O43293 | protein_coding | tolerated(0.21) | benign(0.096) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DAPK3 | SNV | Missense_Mutation | c.647N>T | p.Pro216Leu | p.P216L | O43293 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR | |
DAPK3 | SNV | Missense_Mutation | c.463N>A | p.Pro155Thr | p.P155T | O43293 | protein_coding | deleterious(0.02) | benign(0.247) | TCGA-CI-6621-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1613 | DAPK3 | ENZYME, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME | AST-487 | AST-487 | ||
1613 | DAPK3 | ENZYME, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME | PI-103 | PI-103 | ||
1613 | DAPK3 | ENZYME, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME | CENISERTIB | CENISERTIB | ||
1613 | DAPK3 | ENZYME, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME | ENTRECTINIB | ENTRECTINIB | ||
1613 | DAPK3 | ENZYME, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME | PF-562271 | PF-00562271 | ||
1613 | DAPK3 | ENZYME, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME | DNDI1417467 | CHEMBL1997335 | ||
1613 | DAPK3 | ENZYME, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME | SP-600125 | SP-600125 | 23634759 | |
1613 | DAPK3 | ENZYME, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME | 681640 | CHEMBL379975 | ||
1613 | DAPK3 | ENZYME, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME | TAMATINIB | R-406 | ||
1613 | DAPK3 | ENZYME, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME | AG-1879 | CHEMBL406845 |
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