Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/CAMK2N1_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/CAMK2N1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/CAMK2N1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/CAMK2N1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/CAMK2N1_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/CAMK2N1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/CAMK2N1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/CAMK2N1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/CAMK2N1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000193318 | Prostate | Tumor | negative regulation of protein phosphorylation | 97/3246 | 342/18723 | 2.36e-07 | 5.60e-06 | 97 |
GO:003367316 | Prostate | Tumor | negative regulation of kinase activity | 70/3246 | 237/18723 | 2.27e-06 | 3.87e-05 | 70 |
GO:000646917 | Prostate | Tumor | negative regulation of protein kinase activity | 63/3246 | 212/18723 | 5.73e-06 | 8.78e-05 | 63 |
GO:004340916 | Prostate | Tumor | negative regulation of MAPK cascade | 54/3246 | 180/18723 | 1.92e-05 | 2.50e-04 | 54 |
GO:19040291 | Prostate | Tumor | regulation of cyclin-dependent protein kinase activity | 34/3246 | 98/18723 | 2.60e-05 | 3.18e-04 | 34 |
GO:003428419 | Prostate | Tumor | response to monosaccharide | 60/3246 | 225/18723 | 2.84e-04 | 2.31e-03 | 60 |
GO:004578611 | Prostate | Tumor | negative regulation of cell cycle | 93/3246 | 385/18723 | 3.79e-04 | 2.95e-03 | 93 |
GO:007169214 | Prostate | Tumor | protein localization to extracellular region | 89/3246 | 368/18723 | 4.80e-04 | 3.57e-03 | 89 |
GO:000974319 | Prostate | Tumor | response to carbohydrate | 65/3246 | 253/18723 | 4.97e-04 | 3.66e-03 | 65 |
GO:000930615 | Prostate | Tumor | protein secretion | 87/3246 | 359/18723 | 5.15e-04 | 3.78e-03 | 87 |
GO:003559215 | Prostate | Tumor | establishment of protein localization to extracellular region | 87/3246 | 360/18723 | 5.65e-04 | 4.10e-03 | 87 |
GO:19040301 | Prostate | Tumor | negative regulation of cyclin-dependent protein kinase activity | 14/3246 | 33/18723 | 6.47e-04 | 4.60e-03 | 14 |
GO:000974618 | Prostate | Tumor | response to hexose | 57/3246 | 219/18723 | 7.59e-04 | 5.20e-03 | 57 |
GO:005070814 | Prostate | Tumor | regulation of protein secretion | 66/3246 | 268/18723 | 1.49e-03 | 9.19e-03 | 66 |
GO:005071413 | Prostate | Tumor | positive regulation of protein secretion | 38/3246 | 137/18723 | 1.60e-03 | 9.71e-03 | 38 |
GO:000974916 | Prostate | Tumor | response to glucose | 54/3246 | 212/18723 | 1.74e-03 | 1.03e-02 | 54 |
GO:007037312 | Prostate | Tumor | negative regulation of ERK1 and ERK2 cascade | 24/3246 | 78/18723 | 2.56e-03 | 1.42e-02 | 24 |
GO:190353211 | Prostate | Tumor | positive regulation of secretion by cell | 67/3246 | 282/18723 | 3.53e-03 | 1.82e-02 | 67 |
GO:000167815 | Prostate | Tumor | cellular glucose homeostasis | 44/3246 | 172/18723 | 4.02e-03 | 2.04e-02 | 44 |
GO:007037113 | Prostate | Tumor | ERK1 and ERK2 cascade | 76/3246 | 330/18723 | 4.66e-03 | 2.29e-02 | 76 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAMK2N1 | SNV | Missense_Mutation | novel | c.203N>C | p.Lys68Thr | p.K68T | Q7Z7J9 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.563) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CAMK2N1 | SNV | Missense_Mutation | novel | c.196N>A | p.Val66Met | p.V66M | Q7Z7J9 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.706) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CAMK2N1 | SNV | Missense_Mutation | novel | c.185G>T | p.Arg62Met | p.R62M | Q7Z7J9 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.993) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
CAMK2N1 | SNV | Missense_Mutation | | c.113N>G | p.Ala38Gly | p.A38G | Q7Z7J9 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-CC-A7IH-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
CAMK2N1 | SNV | Missense_Mutation | | c.219N>T | p.Lys73Asn | p.K73N | Q7Z7J9 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.991) | TCGA-50-5930-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxotere | PD |
CAMK2N1 | SNV | Missense_Mutation | novel | c.195N>A | p.Asp65Glu | p.D65E | Q7Z7J9 | protein_coding | tolerated_low_confidence(0.57) | benign(0.005) | TCGA-78-7155-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
CAMK2N1 | SNV | Missense_Mutation | | c.95N>A | p.Thr32Asn | p.T32N | Q7Z7J9 | protein_coding | deleterious_low_confidence(0.01) | benign(0) | TCGA-97-7937-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CAMK2N1 | SNV | Missense_Mutation | novel | c.220N>T | p.Ala74Ser | p.A74S | Q7Z7J9 | protein_coding | tolerated_low_confidence(1) | benign(0.003) | TCGA-39-5040-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | PD |