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Gene: ACTR3 |
Gene summary for ACTR3 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ACTR3 | Gene ID | 10096 |
Gene name | actin related protein 3 | |
Gene Alias | ARP3 | |
Cytomap | 2q14.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | B4DXW1 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10096 | ACTR3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.88e-10 | -4.69e-01 | 0.0155 |
10096 | ACTR3 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.35e-03 | -2.43e-01 | -0.1464 |
10096 | ACTR3 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.15e-04 | -3.96e-01 | 0.096 |
10096 | ACTR3 | HTA11_10711_2000001011 | Human | Colorectum | AD | 7.16e-04 | -4.44e-01 | 0.0338 |
10096 | ACTR3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.25e-07 | -3.91e-01 | 0.0674 |
10096 | ACTR3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.93e-03 | -3.18e-01 | 0.3005 |
10096 | ACTR3 | A015-C-203 | Human | Colorectum | FAP | 1.16e-19 | -3.89e-01 | -0.1294 |
10096 | ACTR3 | A015-C-204 | Human | Colorectum | FAP | 7.67e-04 | -2.72e-01 | -0.0228 |
10096 | ACTR3 | A014-C-040 | Human | Colorectum | FAP | 3.13e-02 | -3.85e-01 | -0.1184 |
10096 | ACTR3 | A002-C-201 | Human | Colorectum | FAP | 9.53e-09 | -2.83e-01 | 0.0324 |
10096 | ACTR3 | A002-C-203 | Human | Colorectum | FAP | 3.70e-02 | -9.83e-02 | 0.2786 |
10096 | ACTR3 | A001-C-119 | Human | Colorectum | FAP | 2.90e-11 | -5.42e-01 | -0.1557 |
10096 | ACTR3 | A001-C-108 | Human | Colorectum | FAP | 2.01e-09 | -2.57e-01 | -0.0272 |
10096 | ACTR3 | A002-C-205 | Human | Colorectum | FAP | 2.32e-19 | -5.11e-01 | -0.1236 |
10096 | ACTR3 | A001-C-104 | Human | Colorectum | FAP | 2.64e-03 | -2.25e-01 | 0.0184 |
10096 | ACTR3 | A015-C-006 | Human | Colorectum | FAP | 2.21e-11 | -4.56e-01 | -0.0994 |
10096 | ACTR3 | A015-C-106 | Human | Colorectum | FAP | 6.74e-10 | -3.03e-01 | -0.0511 |
10096 | ACTR3 | A002-C-114 | Human | Colorectum | FAP | 5.36e-12 | -3.29e-01 | -0.1561 |
10096 | ACTR3 | A015-C-104 | Human | Colorectum | FAP | 2.52e-23 | -5.07e-01 | -0.1899 |
10096 | ACTR3 | A001-C-014 | Human | Colorectum | FAP | 1.44e-10 | -2.97e-01 | 0.0135 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190290319 | Prostate | Tumor | regulation of supramolecular fiber organization | 131/3246 | 383/18723 | 6.68e-16 | 1.26e-13 | 131 |
GO:003297019 | Prostate | Tumor | regulation of actin filament-based process | 133/3246 | 397/18723 | 2.59e-15 | 4.35e-13 | 133 |
GO:000701519 | Prostate | Tumor | actin filament organization | 142/3246 | 442/18723 | 1.40e-14 | 1.89e-12 | 142 |
GO:003295619 | Prostate | Tumor | regulation of actin cytoskeleton organization | 117/3246 | 358/18723 | 8.34e-13 | 8.22e-11 | 117 |
GO:190290519 | Prostate | Tumor | positive regulation of supramolecular fiber organization | 79/3246 | 209/18723 | 1.26e-12 | 1.15e-10 | 79 |
GO:004325419 | Prostate | Tumor | regulation of protein-containing complex assembly | 132/3246 | 428/18723 | 3.32e-12 | 2.78e-10 | 132 |
GO:011005319 | Prostate | Tumor | regulation of actin filament organization | 94/3246 | 278/18723 | 1.77e-11 | 1.25e-09 | 94 |
GO:005149517 | Prostate | Tumor | positive regulation of cytoskeleton organization | 78/3246 | 226/18723 | 3.05e-10 | 1.65e-08 | 78 |
GO:003133419 | Prostate | Tumor | positive regulation of protein-containing complex assembly | 80/3246 | 237/18723 | 6.10e-10 | 3.11e-08 | 80 |
GO:000716317 | Prostate | Tumor | establishment or maintenance of cell polarity | 74/3246 | 218/18723 | 2.00e-09 | 8.86e-08 | 74 |
GO:005125819 | Prostate | Tumor | protein polymerization | 93/3246 | 297/18723 | 2.22e-09 | 9.58e-08 | 93 |
GO:003227119 | Prostate | Tumor | regulation of protein polymerization | 77/3246 | 233/18723 | 3.76e-09 | 1.54e-07 | 77 |
GO:003227318 | Prostate | Tumor | positive regulation of protein polymerization | 51/3246 | 138/18723 | 2.78e-08 | 9.10e-07 | 51 |
GO:003253518 | Prostate | Tumor | regulation of cellular component size | 109/3246 | 383/18723 | 3.56e-08 | 1.12e-06 | 109 |
GO:000815417 | Prostate | Tumor | actin polymerization or depolymerization | 70/3246 | 218/18723 | 6.91e-08 | 1.97e-06 | 70 |
GO:005165614 | Prostate | Tumor | establishment of organelle localization | 109/3246 | 390/18723 | 9.97e-08 | 2.67e-06 | 109 |
GO:003431412 | Prostate | Tumor | Arp2/3 complex-mediated actin nucleation | 21/3246 | 39/18723 | 2.45e-07 | 5.72e-06 | 21 |
GO:003004117 | Prostate | Tumor | actin filament polymerization | 62/3246 | 191/18723 | 2.47e-07 | 5.72e-06 | 62 |
GO:000806416 | Prostate | Tumor | regulation of actin polymerization or depolymerization | 60/3246 | 188/18723 | 7.30e-07 | 1.47e-05 | 60 |
GO:003083317 | Prostate | Tumor | regulation of actin filament polymerization | 56/3246 | 172/18723 | 8.27e-07 | 1.64e-05 | 56 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa05131 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa05100 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa04530 | Colorectum | AD | Tight junction | 76/2092 | 169/8465 | 5.49e-09 | 9.69e-08 | 6.18e-08 | 76 |
hsa05132 | Colorectum | AD | Salmonella infection | 102/2092 | 249/8465 | 7.65e-09 | 1.28e-07 | 8.17e-08 | 102 |
hsa05130 | Colorectum | AD | Pathogenic Escherichia coli infection | 79/2092 | 197/8465 | 1.05e-06 | 1.36e-05 | 8.65e-06 | 79 |
hsa05135 | Colorectum | AD | Yersinia infection | 58/2092 | 137/8465 | 3.90e-06 | 4.35e-05 | 2.78e-05 | 58 |
hsa04810 | Colorectum | AD | Regulation of actin cytoskeleton | 75/2092 | 229/8465 | 3.36e-03 | 1.76e-02 | 1.12e-02 | 75 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa051311 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa051001 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa045301 | Colorectum | AD | Tight junction | 76/2092 | 169/8465 | 5.49e-09 | 9.69e-08 | 6.18e-08 | 76 |
hsa051321 | Colorectum | AD | Salmonella infection | 102/2092 | 249/8465 | 7.65e-09 | 1.28e-07 | 8.17e-08 | 102 |
hsa051301 | Colorectum | AD | Pathogenic Escherichia coli infection | 79/2092 | 197/8465 | 1.05e-06 | 1.36e-05 | 8.65e-06 | 79 |
hsa051351 | Colorectum | AD | Yersinia infection | 58/2092 | 137/8465 | 3.90e-06 | 4.35e-05 | 2.78e-05 | 58 |
hsa048101 | Colorectum | AD | Regulation of actin cytoskeleton | 75/2092 | 229/8465 | 3.36e-03 | 1.76e-02 | 1.12e-02 | 75 |
hsa041444 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa051314 | Colorectum | MSS | Shigellosis | 94/1875 | 247/8465 | 6.82e-09 | 1.34e-07 | 8.23e-08 | 94 |
hsa051324 | Colorectum | MSS | Salmonella infection | 92/1875 | 249/8465 | 5.23e-08 | 9.74e-07 | 5.97e-07 | 92 |
hsa046664 | Colorectum | MSS | Fc gamma R-mediated phagocytosis | 45/1875 | 97/8465 | 9.30e-08 | 1.56e-06 | 9.55e-07 | 45 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ACTR3 | SNV | Missense_Mutation | c.439N>G | p.Leu147Val | p.L147V | P61158 | protein_coding | deleterious(0) | possibly_damaging(0.829) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ACTR3 | insertion | Nonsense_Mutation | novel | c.777_778insCAATAA | p.Ile259_Asn260insGlnTer | p.I259_N260insQ* | P61158 | protein_coding | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ACTR3 | deletion | Frame_Shift_Del | novel | c.1110delN | p.His371ThrfsTer64 | p.H371Tfs*64 | P61158 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
ACTR3 | SNV | Missense_Mutation | novel | c.1001G>A | p.Arg334His | p.R334H | P61158 | protein_coding | deleterious(0.02) | benign(0.357) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ACTR3 | SNV | Missense_Mutation | rs760969306 | c.808G>A | p.Asp270Asn | p.D270N | P61158 | protein_coding | deleterious(0.01) | possibly_damaging(0.69) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ACTR3 | SNV | Missense_Mutation | c.841N>C | p.Ile281Leu | p.I281L | P61158 | protein_coding | tolerated(0.17) | probably_damaging(0.999) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ACTR3 | SNV | Missense_Mutation | novel | c.657N>C | p.Gln219His | p.Q219H | P61158 | protein_coding | deleterious(0.04) | probably_damaging(0.968) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ACTR3 | SNV | Missense_Mutation | c.923C>A | p.Pro308His | p.P308H | P61158 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ACTR3 | SNV | Missense_Mutation | novel | c.1191N>C | p.Lys397Asn | p.K397N | P61158 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ACTR3 | SNV | Missense_Mutation | rs200071930 | c.688C>T | p.Arg230Cys | p.R230C | P61158 | protein_coding | deleterious(0) | probably_damaging(0.92) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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