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Gene: ACAT1 |
Gene summary for ACAT1 |
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Gene information | Species | Human | Gene symbol | ACAT1 | Gene ID | 38 |
Gene name | acetyl-CoA acetyltransferase 1 | |
Gene Alias | ACAT | |
Cytomap | 11q22.3 | |
Gene Type | protein-coding | GO ID | GO:0001655 | UniProtAcc | A0A140VJX1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
38 | ACAT1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.14e-22 | 6.95e-01 | -0.1954 |
38 | ACAT1 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.44e-03 | 4.90e-01 | -0.1526 |
38 | ACAT1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 6.17e-07 | 7.38e-01 | -0.2061 |
38 | ACAT1 | HTA11_6801_2000001011 | Human | Colorectum | SER | 4.25e-04 | 7.47e-01 | 0.0171 |
38 | ACAT1 | HTA11_7469_2000001011 | Human | Colorectum | AD | 1.26e-02 | 7.21e-01 | -0.0124 |
38 | ACAT1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.93e-04 | 4.42e-01 | 0.294 |
38 | ACAT1 | A015-C-203 | Human | Colorectum | FAP | 4.30e-03 | -9.87e-02 | -0.1294 |
38 | ACAT1 | A002-C-205 | Human | Colorectum | FAP | 6.13e-04 | -1.85e-01 | -0.1236 |
38 | ACAT1 | A015-C-104 | Human | Colorectum | FAP | 6.48e-03 | -8.87e-02 | -0.1899 |
38 | ACAT1 | A002-C-116 | Human | Colorectum | FAP | 4.24e-04 | -1.26e-01 | -0.0452 |
38 | ACAT1 | F034 | Human | Colorectum | FAP | 1.44e-02 | -1.10e-01 | -0.0665 |
38 | ACAT1 | F072B | Human | Colorectum | FAP | 2.21e-02 | -1.55e-01 | 0.257 |
38 | ACAT1 | CRC-1-8810 | Human | Colorectum | CRC | 2.07e-02 | -1.36e-01 | 0.6257 |
38 | ACAT1 | LZE3D | Human | Esophagus | HGIN | 1.55e-02 | 5.31e-01 | 0.0668 |
38 | ACAT1 | LZE4T | Human | Esophagus | ESCC | 2.13e-03 | 1.61e-01 | 0.0811 |
38 | ACAT1 | LZE8T | Human | Esophagus | ESCC | 4.12e-06 | 4.26e-02 | 0.067 |
38 | ACAT1 | LZE20T | Human | Esophagus | ESCC | 5.14e-03 | 1.75e-02 | 0.0662 |
38 | ACAT1 | LZE24T | Human | Esophagus | ESCC | 4.55e-10 | 2.97e-01 | 0.0596 |
38 | ACAT1 | P2T-E | Human | Esophagus | ESCC | 2.89e-13 | 1.57e-01 | 0.1177 |
38 | ACAT1 | P4T-E | Human | Esophagus | ESCC | 1.70e-18 | 6.99e-01 | 0.1323 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00338661 | Liver | HCC | nucleoside bisphosphate biosynthetic process | 41/7958 | 60/18723 | 4.65e-05 | 4.49e-04 | 41 |
GO:00340301 | Liver | HCC | ribonucleoside bisphosphate biosynthetic process | 41/7958 | 60/18723 | 4.65e-05 | 4.49e-04 | 41 |
GO:00340331 | Liver | HCC | purine nucleoside bisphosphate biosynthetic process | 41/7958 | 60/18723 | 4.65e-05 | 4.49e-04 | 41 |
GO:1901136 | Liver | HCC | carbohydrate derivative catabolic process | 98/7958 | 172/18723 | 8.71e-05 | 7.62e-04 | 98 |
GO:000616412 | Liver | HCC | purine nucleotide biosynthetic process | 107/7958 | 191/18723 | 1.08e-04 | 9.22e-04 | 107 |
GO:00464342 | Liver | HCC | organophosphate catabolic process | 89/7958 | 155/18723 | 1.24e-04 | 1.03e-03 | 89 |
GO:00090812 | Liver | HCC | branched-chain amino acid metabolic process | 16/7958 | 19/18723 | 2.37e-04 | 1.79e-03 | 16 |
GO:00353841 | Liver | HCC | thioester biosynthetic process | 31/7958 | 45/18723 | 3.11e-04 | 2.21e-03 | 31 |
GO:00716161 | Liver | HCC | acyl-CoA biosynthetic process | 31/7958 | 45/18723 | 3.11e-04 | 2.21e-03 | 31 |
GO:19016062 | Liver | HCC | alpha-amino acid catabolic process | 53/7958 | 87/18723 | 4.01e-04 | 2.71e-03 | 53 |
GO:000908321 | Liver | HCC | branched-chain amino acid catabolic process | 13/7958 | 15/18723 | 5.67e-04 | 3.61e-03 | 13 |
GO:19012921 | Liver | HCC | nucleoside phosphate catabolic process | 49/7958 | 83/18723 | 1.73e-03 | 9.02e-03 | 49 |
GO:00016553 | Liver | HCC | urogenital system development | 170/7958 | 338/18723 | 2.15e-03 | 1.08e-02 | 170 |
GO:00060851 | Liver | HCC | acetyl-CoA biosynthetic process | 14/7958 | 18/18723 | 2.57e-03 | 1.23e-02 | 14 |
GO:0015936 | Liver | HCC | coenzyme A metabolic process | 14/7958 | 18/18723 | 2.57e-03 | 1.23e-02 | 14 |
GO:00018222 | Liver | HCC | kidney development | 148/7958 | 293/18723 | 3.25e-03 | 1.49e-02 | 148 |
GO:00091661 | Liver | HCC | nucleotide catabolic process | 43/7958 | 73/18723 | 3.43e-03 | 1.55e-02 | 43 |
GO:00720012 | Liver | HCC | renal system development | 152/7958 | 302/18723 | 3.45e-03 | 1.56e-02 | 152 |
GO:1901568 | Liver | HCC | fatty acid derivative metabolic process | 43/7958 | 74/18723 | 4.85e-03 | 2.04e-02 | 43 |
GO:000609118 | Oral cavity | OSCC | generation of precursor metabolites and energy | 286/7305 | 490/18723 | 1.45e-18 | 1.71e-16 | 286 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa01200 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa00620 | Colorectum | AD | Pyruvate metabolism | 28/2092 | 47/8465 | 3.71e-07 | 5.41e-06 | 3.45e-06 | 28 |
hsa00280 | Colorectum | AD | Valine, leucine and isoleucine degradation | 25/2092 | 48/8465 | 3.97e-05 | 3.41e-04 | 2.18e-04 | 25 |
hsa00310 | Colorectum | AD | Lysine degradation | 27/2092 | 63/8465 | 1.17e-03 | 7.75e-03 | 4.94e-03 | 27 |
hsa00071 | Colorectum | AD | Fatty acid degradation | 20/2092 | 43/8465 | 1.50e-03 | 8.69e-03 | 5.54e-03 | 20 |
hsa00630 | Colorectum | AD | Glyoxylate and dicarboxylate metabolism | 14/2092 | 30/8465 | 7.25e-03 | 2.97e-02 | 1.89e-02 | 14 |
hsa012001 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa006201 | Colorectum | AD | Pyruvate metabolism | 28/2092 | 47/8465 | 3.71e-07 | 5.41e-06 | 3.45e-06 | 28 |
hsa002801 | Colorectum | AD | Valine, leucine and isoleucine degradation | 25/2092 | 48/8465 | 3.97e-05 | 3.41e-04 | 2.18e-04 | 25 |
hsa003101 | Colorectum | AD | Lysine degradation | 27/2092 | 63/8465 | 1.17e-03 | 7.75e-03 | 4.94e-03 | 27 |
hsa000711 | Colorectum | AD | Fatty acid degradation | 20/2092 | 43/8465 | 1.50e-03 | 8.69e-03 | 5.54e-03 | 20 |
hsa006301 | Colorectum | AD | Glyoxylate and dicarboxylate metabolism | 14/2092 | 30/8465 | 7.25e-03 | 2.97e-02 | 1.89e-02 | 14 |
hsa006202 | Colorectum | SER | Pyruvate metabolism | 22/1580 | 47/8465 | 9.62e-06 | 1.33e-04 | 9.67e-05 | 22 |
hsa012002 | Colorectum | SER | Carbon metabolism | 40/1580 | 115/8465 | 2.77e-05 | 3.41e-04 | 2.47e-04 | 40 |
hsa000712 | Colorectum | SER | Fatty acid degradation | 15/1580 | 43/8465 | 8.60e-03 | 4.26e-02 | 3.09e-02 | 15 |
hsa006203 | Colorectum | SER | Pyruvate metabolism | 22/1580 | 47/8465 | 9.62e-06 | 1.33e-04 | 9.67e-05 | 22 |
hsa012003 | Colorectum | SER | Carbon metabolism | 40/1580 | 115/8465 | 2.77e-05 | 3.41e-04 | 2.47e-04 | 40 |
hsa000713 | Colorectum | SER | Fatty acid degradation | 15/1580 | 43/8465 | 8.60e-03 | 4.26e-02 | 3.09e-02 | 15 |
hsa006204 | Colorectum | MSS | Pyruvate metabolism | 24/1875 | 47/8465 | 1.25e-05 | 1.35e-04 | 8.27e-05 | 24 |
hsa002802 | Colorectum | MSS | Valine, leucine and isoleucine degradation | 21/1875 | 48/8465 | 6.73e-04 | 4.51e-03 | 2.76e-03 | 21 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ACAT1 | SNV | Missense_Mutation | novel | c.906G>T | p.Lys302Asn | p.K302N | P24752 | protein_coding | tolerated(0.12) | benign(0.005) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
ACAT1 | SNV | Missense_Mutation | c.1130N>C | p.Asn377Thr | p.N377T | P24752 | protein_coding | tolerated(0.07) | possibly_damaging(0.732) | TCGA-AR-A256-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | PD | |
ACAT1 | SNV | Missense_Mutation | c.104C>T | p.Ser35Leu | p.S35L | P24752 | protein_coding | tolerated(0.11) | benign(0.007) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
ACAT1 | insertion | Frame_Shift_Ins | novel | c.636_637insTGCAGCCTCCGCCTCCTGG | p.Ala213CysfsTer11 | p.A213Cfs*11 | P24752 | protein_coding | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ACAT1 | SNV | Missense_Mutation | c.1069N>T | p.Ser357Cys | p.S357C | P24752 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ACAT1 | SNV | Missense_Mutation | novel | c.526N>C | p.Glu176Gln | p.E176Q | P24752 | protein_coding | tolerated(0.52) | benign(0.029) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
ACAT1 | SNV | Missense_Mutation | novel | c.1250N>A | p.Gly417Glu | p.G417E | P24752 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
ACAT1 | SNV | Missense_Mutation | rs777462355 | c.1247N>A | p.Gly416Glu | p.G416E | P24752 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ACAT1 | SNV | Missense_Mutation | rs768448235 | c.1142N>C | p.Val381Ala | p.V381A | P24752 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ACAT1 | SNV | Missense_Mutation | rs370720208 | c.623N>A | p.Arg208Gln | p.R208Q | P24752 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
38 | ACAT1 | ENZYME | SULFASALAZINE | SULFASALAZINE | ||
38 | ACAT1 | ENZYME | PMID25470667-Compound-K-604 | |||
38 | ACAT1 | ENZYME | ATR-01 | |||
38 | ACAT1 | ENZYME | inhibitor | 381118860 | ||
38 | ACAT1 | ENZYME | SULFASALAZINE | SULFASALAZINE |
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