GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000915224 | Thyroid | PTC | purine ribonucleotide biosynthetic process | 78/5968 | 169/18723 | 6.88e-05 | 6.01e-04 | 78 |
GO:004639024 | Thyroid | PTC | ribose phosphate biosynthetic process | 85/5968 | 190/18723 | 1.30e-04 | 1.03e-03 | 85 |
GO:000926024 | Thyroid | PTC | ribonucleotide biosynthetic process | 81/5968 | 182/18723 | 2.27e-04 | 1.65e-03 | 81 |
GO:007252219 | Thyroid | PTC | purine-containing compound biosynthetic process | 86/5968 | 200/18723 | 5.85e-04 | 3.72e-03 | 86 |
GO:000616419 | Thyroid | PTC | purine nucleotide biosynthetic process | 81/5968 | 191/18723 | 1.35e-03 | 7.65e-03 | 81 |
GO:00442726 | Thyroid | PTC | sulfur compound biosynthetic process | 63/5968 | 148/18723 | 3.91e-03 | 1.87e-02 | 63 |
GO:002241124 | Thyroid | ATC | cellular component disassembly | 248/6293 | 443/18723 | 1.34e-22 | 3.69e-20 | 248 |
GO:001623623 | Thyroid | ATC | macroautophagy | 169/6293 | 291/18723 | 6.56e-18 | 7.69e-16 | 169 |
GO:003298422 | Thyroid | ATC | protein-containing complex disassembly | 121/6293 | 224/18723 | 2.25e-10 | 6.59e-09 | 121 |
GO:001969328 | Thyroid | ATC | ribose phosphate metabolic process | 184/6293 | 396/18723 | 5.87e-08 | 1.05e-06 | 184 |
GO:000915029 | Thyroid | ATC | purine ribonucleotide metabolic process | 172/6293 | 368/18723 | 9.58e-08 | 1.64e-06 | 172 |
GO:000925928 | Thyroid | ATC | ribonucleotide metabolic process | 178/6293 | 385/18723 | 1.47e-07 | 2.39e-06 | 178 |
GO:007252128 | Thyroid | ATC | purine-containing compound metabolic process | 189/6293 | 416/18723 | 2.83e-07 | 4.29e-06 | 189 |
GO:0006753111 | Thyroid | ATC | nucleoside phosphate metabolic process | 219/6293 | 497/18723 | 5.92e-07 | 8.29e-06 | 219 |
GO:0009117112 | Thyroid | ATC | nucleotide metabolic process | 215/6293 | 489/18723 | 9.09e-07 | 1.20e-05 | 215 |
GO:000616328 | Thyroid | ATC | purine nucleotide metabolic process | 177/6293 | 396/18723 | 2.39e-06 | 2.82e-05 | 177 |
GO:000915225 | Thyroid | ATC | purine ribonucleotide biosynthetic process | 84/6293 | 169/18723 | 1.05e-05 | 1.04e-04 | 84 |
GO:004639025 | Thyroid | ATC | ribose phosphate biosynthetic process | 92/6293 | 190/18723 | 1.57e-05 | 1.46e-04 | 92 |
GO:000926025 | Thyroid | ATC | ribonucleotide biosynthetic process | 88/6293 | 182/18723 | 2.55e-05 | 2.20e-04 | 88 |
GO:007252223 | Thyroid | ATC | purine-containing compound biosynthetic process | 92/6293 | 200/18723 | 1.74e-04 | 1.18e-03 | 92 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TEC | SNV | Missense_Mutation | | c.1117A>T | p.Met373Leu | p.M373L | P42680 | protein_coding | tolerated(1) | benign(0.037) | TCGA-A8-A09K-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TEC | SNV | Missense_Mutation | rs780984861 | c.1393N>A | p.Val465Ile | p.V465I | P42680 | protein_coding | tolerated(0.23) | benign(0.001) | TCGA-AO-A12A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
TEC | SNV | Missense_Mutation | | c.1564T>G | p.Ser522Ala | p.S522A | P42680 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-C8-A1HM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | CR |
TEC | SNV | Missense_Mutation | | c.1191C>G | p.Ile397Met | p.I397M | P42680 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TEC | SNV | Missense_Mutation | | c.700N>T | p.Val234Leu | p.V234L | P42680 | protein_coding | tolerated(0.4) | probably_damaging(0.997) | TCGA-C8-A278-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | SD |
TEC | SNV | Missense_Mutation | rs761984494 | c.806N>A | p.Gly269Asp | p.G269D | P42680 | protein_coding | deleterious(0) | benign(0.403) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD |
TEC | insertion | In_Frame_Ins | novel | c.587_588insAAATATAAAATTTAATTTCCCTCAAGGTCAAAATAATCACATTAAACA | p.Gly195_His196insGlnAsnIleLysPheAsnPheProGlnGlyGlnAsnAsnHisIleLys | p.G195_H196insQNIKFNFPQGQNNHIK | P42680 | protein_coding | | | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
TEC | deletion | Frame_Shift_Del | novel | c.1348delN | p.Leu450PhefsTer2 | p.L450Ffs*2 | P42680 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
TEC | SNV | Missense_Mutation | rs750190240 | c.700N>A | p.Val234Ile | p.V234I | P42680 | protein_coding | tolerated(0.08) | probably_damaging(0.994) | TCGA-ZJ-AAXB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TEC | SNV | Missense_Mutation | rs539573453 | c.550N>A | p.Val184Ile | p.V184I | P42680 | protein_coding | deleterious(0.05) | benign(0.039) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |