Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/SNX1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/SNX1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/SNX1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/SNX1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/SNX1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/SNX1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001619713 | Prostate | Tumor | endosomal transport | 62/3246 | 230/18723 | 1.65e-04 | 1.47e-03 | 62 |
GO:009758114 | Prostate | Tumor | lamellipodium organization | 30/3246 | 90/18723 | 1.73e-04 | 1.53e-03 | 30 |
GO:000182213 | Prostate | Tumor | kidney development | 74/3246 | 293/18723 | 3.68e-04 | 2.87e-03 | 74 |
GO:007200113 | Prostate | Tumor | renal system development | 75/3246 | 302/18723 | 5.74e-04 | 4.13e-03 | 75 |
GO:000320511 | Prostate | Tumor | cardiac chamber development | 43/3246 | 161/18723 | 1.86e-03 | 1.09e-02 | 43 |
GO:003162313 | Prostate | Tumor | receptor internalization | 32/3246 | 113/18723 | 2.51e-03 | 1.40e-02 | 32 |
GO:000327911 | Prostate | Tumor | cardiac septum development | 29/3246 | 103/18723 | 4.26e-03 | 2.13e-02 | 29 |
GO:007267311 | Prostate | Tumor | lamellipodium morphogenesis | 8/3246 | 17/18723 | 4.45e-03 | 2.20e-02 | 8 |
GO:004214712 | Prostate | Tumor | retrograde transport, endosome to Golgi | 25/3246 | 91/18723 | 1.05e-02 | 4.38e-02 | 25 |
GO:004217628 | Skin | AK | regulation of protein catabolic process | 101/1910 | 391/18723 | 4.78e-19 | 9.43e-16 | 101 |
GO:004573228 | Skin | AK | positive regulation of protein catabolic process | 57/1910 | 231/18723 | 1.72e-10 | 2.49e-08 | 57 |
GO:000989627 | Skin | AK | positive regulation of catabolic process | 94/1910 | 492/18723 | 1.32e-09 | 1.26e-07 | 94 |
GO:001648215 | Skin | AK | cytosolic transport | 36/1910 | 168/18723 | 1.26e-05 | 2.56e-04 | 36 |
GO:001619716 | Skin | AK | endosomal transport | 41/1910 | 230/18723 | 2.76e-04 | 2.93e-03 | 41 |
GO:004819319 | Skin | AK | Golgi vesicle transport | 47/1910 | 296/18723 | 1.46e-03 | 1.06e-02 | 47 |
GO:009758117 | Skin | AK | lamellipodium organization | 19/1910 | 90/18723 | 1.61e-03 | 1.15e-02 | 19 |
GO:00421478 | Skin | AK | retrograde transport, endosome to Golgi | 19/1910 | 91/18723 | 1.84e-03 | 1.27e-02 | 19 |
GO:004217629 | Skin | cSCC | regulation of protein catabolic process | 198/4864 | 391/18723 | 6.03e-26 | 1.89e-23 | 198 |
GO:0048193110 | Skin | cSCC | Golgi vesicle transport | 153/4864 | 296/18723 | 1.85e-21 | 3.41e-19 | 153 |
GO:0022411112 | Skin | cSCC | cellular component disassembly | 201/4864 | 443/18723 | 4.09e-19 | 5.69e-17 | 201 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNX1 | SNV | Missense_Mutation | novel | c.38N>C | p.Arg13Thr | p.R13T | Q13596 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.886) | TCGA-A2-A0YK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
SNX1 | SNV | Missense_Mutation | | c.76G>A | p.Glu26Lys | p.E26K | Q13596 | protein_coding | tolerated_low_confidence(0.25) | benign(0.221) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SNX1 | SNV | Missense_Mutation | rs780100137 | c.1424N>A | p.Arg475Gln | p.R475Q | Q13596 | protein_coding | deleterious(0.04) | probably_damaging(0.939) | TCGA-BH-A0BT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
SNX1 | insertion | Nonsense_Mutation | novel | c.1435_1436insGGCCTTCCTGAGGCCTAGTCCCCCTGTTCTTTTTC | p.Ile479ArgfsTer4 | p.I479Rfs*4 | Q13596 | protein_coding | | | TCGA-A8-A06P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | | SD |
SNX1 | insertion | In_Frame_Ins | novel | c.478_479insGTAAAC | p.Asn160delinsSerLysHis | p.N160delinsSKH | Q13596 | protein_coding | | | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SNX1 | SNV | Missense_Mutation | rs754631936 | c.1300N>A | p.Glu434Lys | p.E434K | Q13596 | protein_coding | tolerated(0.6) | probably_damaging(0.973) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SNX1 | SNV | Missense_Mutation | | c.1306C>T | p.Arg436Trp | p.R436W | Q13596 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-C5-A2M2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SNX1 | SNV | Missense_Mutation | | c.262C>G | p.Leu88Val | p.L88V | Q13596 | protein_coding | deleterious(0.01) | possibly_damaging(0.668) | TCGA-EK-A2RJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SNX1 | SNV | Missense_Mutation | | c.76N>C | p.Glu26Gln | p.E26Q | Q13596 | protein_coding | tolerated_low_confidence(0.19) | possibly_damaging(0.51) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
SNX1 | SNV | Missense_Mutation | novel | c.1291C>T | p.Arg431Trp | p.R431W | Q13596 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |