Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/RIN2_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/RIN2_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/RIN2_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/RIN2_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/RIN2_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/RIN2_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/RIN2_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/RIN2_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/RIN2_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001081011 | Stomach | CAG with IM | regulation of cell-substrate adhesion | 24/1050 | 221/18723 | 1.50e-03 | 1.69e-02 | 24 |
GO:001081111 | Stomach | CAG with IM | positive regulation of cell-substrate adhesion | 15/1050 | 123/18723 | 3.71e-03 | 3.28e-02 | 15 |
GO:001063411 | Stomach | CAG with IM | positive regulation of epithelial cell migration | 19/1050 | 176/18723 | 4.73e-03 | 3.86e-02 | 19 |
GO:004578521 | Stomach | CSG | positive regulation of cell adhesion | 47/1034 | 437/18723 | 9.72e-06 | 3.36e-04 | 47 |
GO:003158921 | Stomach | CSG | cell-substrate adhesion | 34/1034 | 363/18723 | 1.88e-03 | 1.99e-02 | 34 |
GO:001081021 | Stomach | CSG | regulation of cell-substrate adhesion | 23/1034 | 221/18723 | 2.65e-03 | 2.55e-02 | 23 |
GO:001063421 | Stomach | CSG | positive regulation of epithelial cell migration | 19/1034 | 176/18723 | 4.01e-03 | 3.48e-02 | 19 |
GO:000166711 | Stomach | CSG | ameboidal-type cell migration | 40/1034 | 475/18723 | 5.35e-03 | 4.31e-02 | 40 |
GO:004578531 | Stomach | CAG | positive regulation of cell adhesion | 30/552 | 437/18723 | 1.74e-05 | 6.48e-04 | 30 |
GO:00106316 | Stomach | CAG | epithelial cell migration | 22/552 | 357/18723 | 9.72e-04 | 1.41e-02 | 22 |
GO:00901326 | Stomach | CAG | epithelium migration | 22/552 | 360/18723 | 1.08e-03 | 1.48e-02 | 22 |
GO:00901306 | Stomach | CAG | tissue migration | 22/552 | 365/18723 | 1.29e-03 | 1.70e-02 | 22 |
GO:00435424 | Stomach | CAG | endothelial cell migration | 18/552 | 279/18723 | 1.65e-03 | 1.94e-02 | 18 |
GO:001063431 | Stomach | CAG | positive regulation of epithelial cell migration | 12/552 | 176/18723 | 6.08e-03 | 4.87e-02 | 12 |
GO:00106326 | Stomach | CAG | regulation of epithelial cell migration | 17/552 | 292/18723 | 6.18e-03 | 4.89e-02 | 17 |
GO:0051098113 | Thyroid | PTC | regulation of binding | 195/5968 | 363/18723 | 3.21e-18 | 3.37e-16 | 195 |
GO:0045862113 | Thyroid | PTC | positive regulation of proteolysis | 198/5968 | 372/18723 | 6.68e-18 | 6.91e-16 | 198 |
GO:0006417113 | Thyroid | PTC | regulation of translation | 236/5968 | 468/18723 | 2.70e-17 | 2.52e-15 | 236 |
GO:0022604112 | Thyroid | PTC | regulation of cell morphogenesis | 165/5968 | 309/18723 | 2.60e-15 | 1.82e-13 | 165 |
GO:0016055110 | Thyroid | PTC | Wnt signaling pathway | 217/5968 | 444/18723 | 3.71e-14 | 2.30e-12 | 217 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RIN2 | SNV | Missense_Mutation | | c.343N>C | p.Glu115Gln | p.E115Q | Q8WYP3 | protein_coding | tolerated_low_confidence(0.16) | benign(0.023) | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | | SD |
RIN2 | SNV | Missense_Mutation | | c.1117C>G | p.Arg373Gly | p.R373G | Q8WYP3 | protein_coding | tolerated(0.39) | benign(0) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
RIN2 | SNV | Missense_Mutation | novel | c.2069T>G | p.Val690Gly | p.V690G | Q8WYP3 | protein_coding | deleterious(0) | probably_damaging(0.958) | TCGA-A7-A0DA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
RIN2 | SNV | Missense_Mutation | | c.654N>G | p.Phe218Leu | p.F218L | Q8WYP3 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AN-A0FT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RIN2 | SNV | Missense_Mutation | novel | c.2069N>G | p.Val690Gly | p.V690G | Q8WYP3 | protein_coding | deleterious(0) | probably_damaging(0.958) | TCGA-BH-A1F8-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
RIN2 | SNV | Missense_Mutation | novel | c.2069T>G | p.Val690Gly | p.V690G | Q8WYP3 | protein_coding | deleterious(0) | probably_damaging(0.958) | TCGA-D8-A1XG-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
RIN2 | SNV | Missense_Mutation | novel | c.2069N>G | p.Val690Gly | p.V690G | Q8WYP3 | protein_coding | deleterious(0) | probably_damaging(0.958) | TCGA-D8-A1XO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
RIN2 | insertion | Frame_Shift_Ins | novel | c.1867_1868insAGGAAGGAGAATCACTTGAACCTGGGAGGTGG | p.Leu623GlnfsTer19 | p.L623Qfs*19 | Q8WYP3 | protein_coding | | | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD |
RIN2 | insertion | In_Frame_Ins | novel | c.1805_1806insACTTCCTCCTCC | p.Met602delinsIleLeuProProPro | p.M602delinsILPPP | Q8WYP3 | protein_coding | | | TCGA-BH-A0BJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
RIN2 | insertion | Frame_Shift_Ins | novel | c.1806_1807insACTCGCTGGAGTTCGACCGGAGCATGCCT | p.Leu603ThrfsTer18 | p.L603Tfs*18 | Q8WYP3 | protein_coding | | | TCGA-BH-A0BJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |