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Gene: NEDD4L |
Gene summary for NEDD4L |
Gene summary. |
Gene information | Species | Human | Gene symbol | NEDD4L | Gene ID | 23327 |
Gene name | NEDD4 like E3 ubiquitin protein ligase | |
Gene Alias | NEDD4-2 | |
Cytomap | 18q21.31 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | A0A024R2A4 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23327 | NEDD4L | CCI_1 | Human | Cervix | CC | 7.51e-25 | 1.54e+00 | 0.528 |
23327 | NEDD4L | CCI_2 | Human | Cervix | CC | 3.57e-15 | 1.54e+00 | 0.5249 |
23327 | NEDD4L | CCI_3 | Human | Cervix | CC | 1.32e-21 | 1.33e+00 | 0.516 |
23327 | NEDD4L | CCII_1 | Human | Cervix | CC | 1.56e-09 | 4.95e-01 | 0.3249 |
23327 | NEDD4L | sample1 | Human | Cervix | CC | 3.05e-09 | 5.17e-01 | 0.0959 |
23327 | NEDD4L | H2 | Human | Cervix | HSIL_HPV | 5.87e-06 | 2.28e-01 | 0.0632 |
23327 | NEDD4L | T1 | Human | Cervix | CC | 1.63e-22 | 6.34e-01 | 0.0918 |
23327 | NEDD4L | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.20e-24 | -6.52e-01 | 0.0155 |
23327 | NEDD4L | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.17e-07 | -9.52e-01 | 0.0216 |
23327 | NEDD4L | HTA11_347_2000001011 | Human | Colorectum | AD | 1.01e-08 | 5.69e-01 | -0.1954 |
23327 | NEDD4L | HTA11_411_2000001011 | Human | Colorectum | SER | 1.05e-10 | 1.18e+00 | -0.2602 |
23327 | NEDD4L | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.25e-02 | 5.58e-01 | -0.2196 |
23327 | NEDD4L | HTA11_9341_2000001011 | Human | Colorectum | SER | 3.57e-02 | -5.89e-01 | -0.00410000000000005 |
23327 | NEDD4L | HTA11_866_3004761011 | Human | Colorectum | AD | 2.46e-04 | -4.98e-01 | 0.096 |
23327 | NEDD4L | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.51e-02 | -5.17e-01 | 0.0528 |
23327 | NEDD4L | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.13e-04 | -3.57e-01 | 0.294 |
23327 | NEDD4L | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.28e-03 | 4.10e-01 | 0.281 |
23327 | NEDD4L | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.79e-12 | -4.95e-01 | 0.3859 |
23327 | NEDD4L | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.84e-14 | -9.36e-01 | 0.2585 |
23327 | NEDD4L | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.04e-38 | -8.51e-01 | 0.3005 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002260422 | Liver | HCC | regulation of cell morphogenesis | 188/7958 | 309/18723 | 4.84e-11 | 1.82e-09 | 188 |
GO:007093621 | Liver | HCC | protein K48-linked ubiquitination | 52/7958 | 65/18723 | 6.70e-10 | 2.11e-08 | 52 |
GO:001604921 | Liver | HCC | cell growth | 269/7958 | 482/18723 | 1.84e-09 | 5.35e-08 | 269 |
GO:000155821 | Liver | HCC | regulation of cell growth | 228/7958 | 414/18723 | 1.34e-07 | 2.55e-06 | 228 |
GO:001003822 | Liver | HCC | response to metal ion | 208/7958 | 373/18723 | 1.35e-07 | 2.56e-06 | 208 |
GO:190382811 | Liver | HCC | negative regulation of cellular protein localization | 71/7958 | 117/18723 | 5.44e-05 | 5.12e-04 | 71 |
GO:003010021 | Liver | HCC | regulation of endocytosis | 117/7958 | 211/18723 | 9.56e-05 | 8.32e-04 | 117 |
GO:000651311 | Liver | HCC | protein monoubiquitination | 44/7958 | 67/18723 | 1.08e-04 | 9.22e-04 | 44 |
GO:004580721 | Liver | HCC | positive regulation of endocytosis | 59/7958 | 100/18723 | 6.35e-04 | 3.93e-03 | 59 |
GO:006056011 | Liver | HCC | developmental growth involved in morphogenesis | 124/7958 | 234/18723 | 7.37e-04 | 4.47e-03 | 124 |
GO:001097511 | Liver | HCC | regulation of neuron projection development | 220/7958 | 445/18723 | 1.68e-03 | 8.78e-03 | 220 |
GO:199013811 | Liver | HCC | neuron projection extension | 92/7958 | 172/18723 | 2.31e-03 | 1.14e-02 | 92 |
GO:004858811 | Liver | HCC | developmental cell growth | 121/7958 | 234/18723 | 2.68e-03 | 1.28e-02 | 121 |
GO:003030711 | Liver | HCC | positive regulation of cell growth | 88/7958 | 166/18723 | 3.95e-03 | 1.74e-02 | 88 |
GO:001635811 | Liver | HCC | dendrite development | 121/7958 | 243/18723 | 1.26e-02 | 4.56e-02 | 121 |
GO:004592711 | Liver | HCC | positive regulation of growth | 128/7958 | 259/18723 | 1.41e-02 | 4.99e-02 | 128 |
GO:00098968 | Lung | IAC | positive regulation of catabolic process | 114/2061 | 492/18723 | 4.93e-15 | 1.25e-11 | 114 |
GO:00421768 | Lung | IAC | regulation of protein catabolic process | 97/2061 | 391/18723 | 6.32e-15 | 1.25e-11 | 97 |
GO:00457328 | Lung | IAC | positive regulation of protein catabolic process | 61/2061 | 231/18723 | 4.44e-11 | 1.39e-08 | 61 |
GO:00226048 | Lung | IAC | regulation of cell morphogenesis | 74/2061 | 309/18723 | 6.31e-11 | 1.70e-08 | 74 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0412014 | Cervix | CC | Ubiquitin mediated proteolysis | 49/1267 | 142/8465 | 4.26e-09 | 7.68e-08 | 4.54e-08 | 49 |
hsa0453020 | Cervix | CC | Tight junction | 49/1267 | 169/8465 | 1.87e-06 | 1.78e-05 | 1.05e-05 | 49 |
hsa0414418 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
hsa0412015 | Cervix | CC | Ubiquitin mediated proteolysis | 49/1267 | 142/8465 | 4.26e-09 | 7.68e-08 | 4.54e-08 | 49 |
hsa04530110 | Cervix | CC | Tight junction | 49/1267 | 169/8465 | 1.87e-06 | 1.78e-05 | 1.05e-05 | 49 |
hsa0414419 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa04530 | Colorectum | AD | Tight junction | 76/2092 | 169/8465 | 5.49e-09 | 9.69e-08 | 6.18e-08 | 76 |
hsa04120 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa045301 | Colorectum | AD | Tight junction | 76/2092 | 169/8465 | 5.49e-09 | 9.69e-08 | 6.18e-08 | 76 |
hsa041201 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa041442 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa045302 | Colorectum | SER | Tight junction | 59/1580 | 169/8465 | 3.24e-07 | 5.98e-06 | 4.34e-06 | 59 |
hsa041202 | Colorectum | SER | Ubiquitin mediated proteolysis | 39/1580 | 142/8465 | 6.18e-03 | 3.66e-02 | 2.66e-02 | 39 |
hsa041443 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa045303 | Colorectum | SER | Tight junction | 59/1580 | 169/8465 | 3.24e-07 | 5.98e-06 | 4.34e-06 | 59 |
hsa041203 | Colorectum | SER | Ubiquitin mediated proteolysis | 39/1580 | 142/8465 | 6.18e-03 | 3.66e-02 | 2.66e-02 | 39 |
hsa041444 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa045304 | Colorectum | MSS | Tight junction | 66/1875 | 169/8465 | 4.10e-07 | 6.25e-06 | 3.83e-06 | 66 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NEDD4L | SNV | Missense_Mutation | c.1937C>A | p.Ala646Asp | p.A646D | Q96PU5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A2-A25E-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | PD | |
NEDD4L | SNV | Missense_Mutation | c.2518A>G | p.Ile840Val | p.I840V | Q96PU5 | protein_coding | tolerated(0.09) | benign(0.127) | TCGA-A8-A094-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NEDD4L | SNV | Missense_Mutation | c.2003T>A | p.Phe668Tyr | p.F668Y | Q96PU5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A8-A09K-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NEDD4L | SNV | Missense_Mutation | c.2848N>G | p.Pro950Ala | p.P950A | Q96PU5 | protein_coding | deleterious(0.02) | benign(0.031) | TCGA-AN-A03Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NEDD4L | SNV | Missense_Mutation | c.1402N>G | p.Arg468Gly | p.R468G | Q96PU5 | protein_coding | tolerated(0.1) | benign(0.048) | TCGA-BH-A0B9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
NEDD4L | SNV | Missense_Mutation | c.229G>C | p.Glu77Gln | p.E77Q | Q96PU5 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-BH-A0HP-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD | |
NEDD4L | SNV | Missense_Mutation | c.532G>C | p.Asp178His | p.D178H | Q96PU5 | protein_coding | deleterious(0) | possibly_damaging(0.897) | TCGA-C8-A1HF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NEDD4L | SNV | Missense_Mutation | c.52N>C | p.Glu18Gln | p.E18Q | Q96PU5 | protein_coding | tolerated(0.33) | benign(0.269) | TCGA-C8-A1HM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | CR | |
NEDD4L | SNV | Missense_Mutation | novel | c.2524N>C | p.Ile842Leu | p.I842L | Q96PU5 | protein_coding | tolerated(0.06) | benign(0.02) | TCGA-D8-A1XJ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
NEDD4L | SNV | Missense_Mutation | novel | c.2524N>G | p.Ile842Val | p.I842V | Q96PU5 | protein_coding | deleterious(0.02) | benign(0.038) | TCGA-WT-AB41-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
23327 | NEDD4L | ENZYME | diuretics | 18591455,21052022 | ||
23327 | NEDD4L | ENZYME | citalopram | CITALOPRAM | 23809733 | |
23327 | NEDD4L | ENZYME | hydrochlorothiazide | HYDROCHLOROTHIAZIDE | 18591455,21052022,19635985 |
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