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Gene: DYNLT1 |
Gene summary for DYNLT1 |
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Gene information | Species | Human | Gene symbol | DYNLT1 | Gene ID | 6993 |
Gene name | dynein light chain Tctex-type 1 | |
Gene Alias | CW-1 | |
Cytomap | 6q25.3 | |
Gene Type | protein-coding | GO ID | GO:0000132 | UniProtAcc | P63172 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6993 | DYNLT1 | GSM4909281 | Human | Breast | IDC | 3.29e-12 | 4.26e-01 | 0.21 |
6993 | DYNLT1 | GSM4909285 | Human | Breast | IDC | 1.91e-24 | 5.55e-01 | 0.21 |
6993 | DYNLT1 | GSM4909286 | Human | Breast | IDC | 2.36e-03 | 2.87e-01 | 0.1081 |
6993 | DYNLT1 | GSM4909288 | Human | Breast | IDC | 3.29e-02 | -1.42e-01 | 0.0988 |
6993 | DYNLT1 | GSM4909290 | Human | Breast | IDC | 2.23e-22 | 5.73e-01 | 0.2096 |
6993 | DYNLT1 | GSM4909294 | Human | Breast | IDC | 2.04e-20 | 3.07e-01 | 0.2022 |
6993 | DYNLT1 | GSM4909296 | Human | Breast | IDC | 3.97e-10 | -1.13e-01 | 0.1524 |
6993 | DYNLT1 | GSM4909297 | Human | Breast | IDC | 5.35e-22 | -4.15e-01 | 0.1517 |
6993 | DYNLT1 | GSM4909298 | Human | Breast | IDC | 1.25e-02 | 2.46e-01 | 0.1551 |
6993 | DYNLT1 | GSM4909301 | Human | Breast | IDC | 8.10e-12 | 2.94e-01 | 0.1577 |
6993 | DYNLT1 | GSM4909306 | Human | Breast | IDC | 2.17e-21 | 5.30e-01 | 0.1564 |
6993 | DYNLT1 | GSM4909307 | Human | Breast | IDC | 4.61e-25 | 5.05e-01 | 0.1569 |
6993 | DYNLT1 | GSM4909308 | Human | Breast | IDC | 5.88e-35 | 6.15e-01 | 0.158 |
6993 | DYNLT1 | GSM4909311 | Human | Breast | IDC | 3.13e-44 | -2.60e-01 | 0.1534 |
6993 | DYNLT1 | GSM4909312 | Human | Breast | IDC | 3.81e-09 | -2.29e-02 | 0.1552 |
6993 | DYNLT1 | GSM4909315 | Human | Breast | IDC | 1.12e-49 | 7.39e-01 | 0.21 |
6993 | DYNLT1 | GSM4909316 | Human | Breast | IDC | 2.19e-23 | 5.85e-01 | 0.21 |
6993 | DYNLT1 | GSM4909318 | Human | Breast | IDC | 7.90e-04 | 1.91e-01 | 0.2031 |
6993 | DYNLT1 | GSM4909319 | Human | Breast | IDC | 1.17e-53 | -4.14e-01 | 0.1563 |
6993 | DYNLT1 | GSM4909320 | Human | Breast | IDC | 2.40e-06 | -2.39e-01 | 0.1575 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001635814 | Prostate | Tumor | dendrite development | 72/3246 | 243/18723 | 1.44e-06 | 2.59e-05 | 72 |
GO:001097514 | Prostate | Tumor | regulation of neuron projection development | 115/3246 | 445/18723 | 3.34e-06 | 5.44e-05 | 115 |
GO:003134614 | Prostate | Tumor | positive regulation of cell projection organization | 94/3246 | 353/18723 | 6.96e-06 | 1.05e-04 | 94 |
GO:003001015 | Prostate | Tumor | establishment of cell polarity | 46/3246 | 143/18723 | 1.09e-05 | 1.56e-04 | 46 |
GO:005105613 | Prostate | Tumor | regulation of small GTPase mediated signal transduction | 80/3246 | 302/18723 | 3.96e-05 | 4.57e-04 | 80 |
GO:005076711 | Prostate | Tumor | regulation of neurogenesis | 93/3246 | 364/18723 | 4.45e-05 | 5.02e-04 | 93 |
GO:006156413 | Prostate | Tumor | axon development | 113/3246 | 467/18723 | 8.86e-05 | 8.74e-04 | 113 |
GO:004308713 | Prostate | Tumor | regulation of GTPase activity | 88/3246 | 348/18723 | 1.04e-04 | 1.00e-03 | 88 |
GO:004657814 | Prostate | Tumor | regulation of Ras protein signal transduction | 53/3246 | 189/18723 | 1.63e-04 | 1.46e-03 | 53 |
GO:001660112 | Prostate | Tumor | Rac protein signal transduction | 17/3246 | 42/18723 | 3.45e-04 | 2.73e-03 | 17 |
GO:000700616 | Prostate | Tumor | mitochondrial membrane organization | 35/3246 | 116/18723 | 4.65e-04 | 3.48e-03 | 35 |
GO:190285013 | Prostate | Tumor | microtubule cytoskeleton organization involved in mitosis | 41/3246 | 147/18723 | 9.53e-04 | 6.20e-03 | 41 |
GO:009055915 | Prostate | Tumor | regulation of membrane permeability | 25/3246 | 78/18723 | 1.11e-03 | 7.12e-03 | 25 |
GO:005196011 | Prostate | Tumor | regulation of nervous system development | 102/3246 | 443/18723 | 1.20e-03 | 7.60e-03 | 102 |
GO:001097611 | Prostate | Tumor | positive regulation of neuron projection development | 42/3246 | 163/18723 | 4.24e-03 | 2.12e-02 | 42 |
GO:004690215 | Prostate | Tumor | regulation of mitochondrial membrane permeability | 19/3246 | 63/18723 | 8.63e-03 | 3.75e-02 | 19 |
GO:001603229 | Skin | cSCC | viral process | 211/4864 | 415/18723 | 7.04e-28 | 2.76e-25 | 211 |
GO:001905829 | Skin | cSCC | viral life cycle | 157/4864 | 317/18723 | 1.29e-19 | 1.88e-17 | 157 |
GO:005165624 | Skin | cSCC | establishment of organelle localization | 178/4864 | 390/18723 | 2.18e-17 | 2.32e-15 | 178 |
GO:190285016 | Skin | cSCC | microtubule cytoskeleton organization involved in mitosis | 85/4864 | 147/18723 | 2.66e-16 | 2.39e-14 | 85 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513218 | Breast | Precancer | Salmonella infection | 49/684 | 249/8465 | 2.92e-09 | 6.15e-08 | 4.71e-08 | 49 |
hsa0513219 | Breast | Precancer | Salmonella infection | 49/684 | 249/8465 | 2.92e-09 | 6.15e-08 | 4.71e-08 | 49 |
hsa0513224 | Breast | IDC | Salmonella infection | 55/867 | 249/8465 | 2.07e-08 | 4.49e-07 | 3.36e-07 | 55 |
hsa0513234 | Breast | IDC | Salmonella infection | 55/867 | 249/8465 | 2.07e-08 | 4.49e-07 | 3.36e-07 | 55 |
hsa0513243 | Breast | DCIS | Salmonella infection | 55/846 | 249/8465 | 8.71e-09 | 1.87e-07 | 1.38e-07 | 55 |
hsa0513253 | Breast | DCIS | Salmonella infection | 55/846 | 249/8465 | 8.71e-09 | 1.87e-07 | 1.38e-07 | 55 |
hsa0513220 | Cervix | CC | Salmonella infection | 74/1267 | 249/8465 | 1.33e-09 | 2.54e-08 | 1.50e-08 | 74 |
hsa05132110 | Cervix | CC | Salmonella infection | 74/1267 | 249/8465 | 1.33e-09 | 2.54e-08 | 1.50e-08 | 74 |
hsa05132 | Colorectum | AD | Salmonella infection | 102/2092 | 249/8465 | 7.65e-09 | 1.28e-07 | 8.17e-08 | 102 |
hsa051321 | Colorectum | AD | Salmonella infection | 102/2092 | 249/8465 | 7.65e-09 | 1.28e-07 | 8.17e-08 | 102 |
hsa051322 | Colorectum | SER | Salmonella infection | 77/1580 | 249/8465 | 1.56e-06 | 2.35e-05 | 1.71e-05 | 77 |
hsa051323 | Colorectum | SER | Salmonella infection | 77/1580 | 249/8465 | 1.56e-06 | 2.35e-05 | 1.71e-05 | 77 |
hsa051324 | Colorectum | MSS | Salmonella infection | 92/1875 | 249/8465 | 5.23e-08 | 9.74e-07 | 5.97e-07 | 92 |
hsa051325 | Colorectum | MSS | Salmonella infection | 92/1875 | 249/8465 | 5.23e-08 | 9.74e-07 | 5.97e-07 | 92 |
hsa051326 | Colorectum | MSI-H | Salmonella infection | 43/797 | 249/8465 | 5.91e-05 | 8.33e-04 | 6.98e-04 | 43 |
hsa051327 | Colorectum | MSI-H | Salmonella infection | 43/797 | 249/8465 | 5.91e-05 | 8.33e-04 | 6.98e-04 | 43 |
hsa0513226 | Endometrium | AEH | Salmonella infection | 71/1197 | 249/8465 | 1.69e-09 | 3.44e-08 | 2.52e-08 | 71 |
hsa048144 | Endometrium | AEH | Motor proteins | 42/1197 | 193/8465 | 2.41e-03 | 1.42e-02 | 1.04e-02 | 42 |
hsa05132112 | Endometrium | AEH | Salmonella infection | 71/1197 | 249/8465 | 1.69e-09 | 3.44e-08 | 2.52e-08 | 71 |
hsa0481411 | Endometrium | AEH | Motor proteins | 42/1197 | 193/8465 | 2.41e-03 | 1.42e-02 | 1.04e-02 | 42 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DYNLT1 | SNV | Missense_Mutation | c.16N>A | p.Ala6Thr | p.A6T | P63172 | protein_coding | tolerated(0.64) | benign(0.001) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DYNLT1 | SNV | Missense_Mutation | novel | c.65N>G | p.Lys22Arg | p.K22R | P63172 | protein_coding | tolerated(0.09) | benign(0.363) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DYNLT1 | SNV | Missense_Mutation | rs142843740 | c.82G>A | p.Ala28Thr | p.A28T | P63172 | protein_coding | tolerated(0.59) | benign(0.003) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DYNLT1 | SNV | Missense_Mutation | novel | c.338T>G | p.Ile113Ser | p.I113S | P63172 | protein_coding | deleterious(0) | probably_damaging(0.925) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DYNLT1 | SNV | Missense_Mutation | rs151068285 | c.13C>G | p.Gln5Glu | p.Q5E | P63172 | protein_coding | tolerated(0.47) | benign(0) | TCGA-35-3615-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DYNLT1 | SNV | Missense_Mutation | c.284N>G | p.Val95Gly | p.V95G | P63172 | protein_coding | deleterious(0) | possibly_damaging(0.777) | TCGA-HC-A4ZV-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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