Tissue | Expression Dynamics | Abbreviation |
Cervix | | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007058525 | Skin | cSCC | protein localization to mitochondrion | 74/4864 | 125/18723 | 3.95e-15 | 3.06e-13 | 74 |
GO:000612026 | Skin | cSCC | mitochondrial electron transport, NADH to ubiquinone | 40/4864 | 51/18723 | 6.69e-15 | 5.06e-13 | 40 |
GO:007265525 | Skin | cSCC | establishment of protein localization to mitochondrion | 71/4864 | 120/18723 | 1.48e-14 | 1.04e-12 | 71 |
GO:000662624 | Skin | cSCC | protein targeting to mitochondrion | 61/4864 | 100/18723 | 1.53e-13 | 9.32e-12 | 61 |
GO:0017038110 | Skin | cSCC | protein import | 100/4864 | 206/18723 | 2.50e-12 | 1.36e-10 | 100 |
GO:004325429 | Skin | cSCC | regulation of protein-containing complex assembly | 167/4864 | 428/18723 | 1.60e-09 | 5.97e-08 | 167 |
GO:007149628 | Skin | cSCC | cellular response to external stimulus | 125/4864 | 320/18723 | 1.63e-07 | 3.65e-06 | 125 |
GO:007180610 | Skin | cSCC | protein transmembrane transport | 33/4864 | 59/18723 | 9.93e-07 | 1.78e-05 | 33 |
GO:00650027 | Skin | cSCC | intracellular protein transmembrane transport | 28/4864 | 51/18723 | 1.05e-05 | 1.37e-04 | 28 |
GO:003166825 | Skin | cSCC | cellular response to extracellular stimulus | 94/4864 | 246/18723 | 1.52e-05 | 1.87e-04 | 94 |
GO:000926722 | Skin | cSCC | cellular response to starvation | 64/4864 | 156/18723 | 2.79e-05 | 3.12e-04 | 64 |
GO:0042594110 | Skin | cSCC | response to starvation | 77/4864 | 197/18723 | 3.52e-05 | 3.82e-04 | 77 |
GO:003166728 | Skin | cSCC | response to nutrient levels | 160/4864 | 474/18723 | 8.44e-05 | 8.02e-04 | 160 |
GO:003166925 | Skin | cSCC | cellular response to nutrient levels | 80/4864 | 215/18723 | 1.76e-04 | 1.50e-03 | 80 |
GO:199054224 | Skin | cSCC | mitochondrial transmembrane transport | 43/4864 | 102/18723 | 2.68e-04 | 2.16e-03 | 43 |
GO:00434578 | Skin | cSCC | regulation of cellular respiration | 24/4864 | 49/18723 | 4.54e-04 | 3.47e-03 | 24 |
GO:003133326 | Skin | cSCC | negative regulation of protein-containing complex assembly | 55/4864 | 141/18723 | 4.57e-04 | 3.49e-03 | 55 |
GO:004346720 | Skin | cSCC | regulation of generation of precursor metabolites and energy | 51/4864 | 130/18723 | 6.18e-04 | 4.46e-03 | 51 |
GO:00301504 | Skin | cSCC | protein import into mitochondrial matrix | 12/4864 | 20/18723 | 1.34e-03 | 8.54e-03 | 12 |
GO:19037159 | Skin | cSCC | regulation of aerobic respiration | 17/4864 | 33/18723 | 1.50e-03 | 9.36e-03 | 17 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DNAJC15 | SNV | Missense_Mutation | novel | c.22G>T | p.Ala8Ser | p.A8S | Q9Y5T4 | protein_coding | tolerated_low_confidence(0.24) | benign(0.049) | TCGA-BH-A0HK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
DNAJC15 | SNV | Missense_Mutation | rs756868611 | c.68C>T | p.Ser23Leu | p.S23L | Q9Y5T4 | protein_coding | deleterious_low_confidence(0.03) | benign(0.017) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
DNAJC15 | SNV | Missense_Mutation | | c.43C>T | p.Arg15Cys | p.R15C | Q9Y5T4 | protein_coding | deleterious_low_confidence(0.04) | probably_damaging(0.997) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
DNAJC15 | SNV | Missense_Mutation | novel | c.269N>C | p.Gln90Pro | p.Q90P | Q9Y5T4 | protein_coding | tolerated(0.69) | benign(0.011) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DNAJC15 | SNV | Missense_Mutation | novel | c.215N>T | p.Ala72Val | p.A72V | Q9Y5T4 | protein_coding | tolerated(0.56) | benign(0.003) | TCGA-AX-A3G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DNAJC15 | SNV | Missense_Mutation | rs115803506 | c.284N>A | p.Arg95Gln | p.R95Q | Q9Y5T4 | protein_coding | tolerated(0.09) | probably_damaging(0.98) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
DNAJC15 | SNV | Missense_Mutation | | c.450T>G | p.His150Gln | p.H150Q | Q9Y5T4 | protein_coding | tolerated_low_confidence(0.19) | benign(0.007) | TCGA-BS-A0TC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DNAJC15 | SNV | Missense_Mutation | | c.369N>G | p.Asn123Lys | p.N123K | Q9Y5T4 | protein_coding | deleterious(0) | probably_damaging(0.951) | TCGA-BS-A0UM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
DNAJC15 | SNV | Missense_Mutation | rs765899911 | c.163N>T | p.Arg55Cys | p.R55C | Q9Y5T4 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
DNAJC15 | SNV | Missense_Mutation | rs760852761 | c.407N>G | p.Lys136Arg | p.K136R | Q9Y5T4 | protein_coding | deleterious(0.03) | probably_damaging(0.98) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |