Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/CDC73_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/CDC73_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/CDC73_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/CDC73_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/CDC73_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/CDC73_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/CDC73_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005067323 | Oral cavity | NEOLP | epithelial cell proliferation | 73/2005 | 437/18723 | 7.74e-05 | 9.93e-04 | 73 |
GO:004578731 | Oral cavity | NEOLP | positive regulation of cell cycle | 55/2005 | 313/18723 | 1.53e-04 | 1.74e-03 | 55 |
GO:003296821 | Oral cavity | NEOLP | positive regulation of transcription elongation from RNA polymerase II promoter | 7/2005 | 13/18723 | 1.53e-04 | 1.74e-03 | 7 |
GO:000651331 | Oral cavity | NEOLP | protein monoubiquitination | 18/2005 | 67/18723 | 1.73e-04 | 1.91e-03 | 18 |
GO:000008231 | Oral cavity | NEOLP | G1/S transition of mitotic cell cycle | 40/2005 | 214/18723 | 3.21e-04 | 3.11e-03 | 40 |
GO:004563724 | Oral cavity | NEOLP | regulation of myeloid cell differentiation | 39/2005 | 210/18723 | 4.32e-04 | 3.93e-03 | 39 |
GO:009006814 | Oral cavity | NEOLP | positive regulation of cell cycle process | 42/2005 | 236/18723 | 6.66e-04 | 5.55e-03 | 42 |
GO:004477231 | Oral cavity | NEOLP | mitotic cell cycle phase transition | 67/2005 | 424/18723 | 7.30e-04 | 5.98e-03 | 67 |
GO:007122231 | Oral cavity | NEOLP | cellular response to lipopolysaccharide | 38/2005 | 209/18723 | 7.74e-04 | 6.23e-03 | 38 |
GO:190198921 | Oral cavity | NEOLP | positive regulation of cell cycle phase transition | 24/2005 | 115/18723 | 1.00e-03 | 7.68e-03 | 24 |
GO:00342433 | Oral cavity | NEOLP | regulation of transcription elongation from RNA polymerase II promoter | 10/2005 | 32/18723 | 1.36e-03 | 9.75e-03 | 10 |
GO:007121631 | Oral cavity | NEOLP | cellular response to biotic stimulus | 42/2005 | 246/18723 | 1.55e-03 | 1.09e-02 | 42 |
GO:004484331 | Oral cavity | NEOLP | cell cycle G1/S phase transition | 41/2005 | 241/18723 | 1.87e-03 | 1.28e-02 | 41 |
GO:000734631 | Oral cavity | NEOLP | regulation of mitotic cell cycle | 69/2005 | 457/18723 | 2.07e-03 | 1.38e-02 | 69 |
GO:007121922 | Oral cavity | NEOLP | cellular response to molecule of bacterial origin | 38/2005 | 221/18723 | 2.22e-03 | 1.44e-02 | 38 |
GO:005067822 | Oral cavity | NEOLP | regulation of epithelial cell proliferation | 59/2005 | 381/18723 | 2.36e-03 | 1.51e-02 | 59 |
GO:00103902 | Oral cavity | NEOLP | histone monoubiquitination | 9/2005 | 29/18723 | 2.48e-03 | 1.57e-02 | 9 |
GO:004814531 | Oral cavity | NEOLP | regulation of fibroblast proliferation | 17/2005 | 80/18723 | 4.25e-03 | 2.40e-02 | 17 |
GO:004814431 | Oral cavity | NEOLP | fibroblast proliferation | 17/2005 | 81/18723 | 4.85e-03 | 2.64e-02 | 17 |
GO:00335232 | Oral cavity | NEOLP | histone H2B ubiquitination | 5/2005 | 12/18723 | 5.81e-03 | 3.04e-02 | 5 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDC73 | SNV | Missense_Mutation | | c.1073G>A | p.Arg358Gln | p.R358Q | Q6P1J9 | protein_coding | deleterious(0.01) | probably_damaging(0.949) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CDC73 | SNV | Missense_Mutation | | c.1352N>T | p.Ala451Val | p.A451V | Q6P1J9 | protein_coding | tolerated(0.06) | benign(0.119) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CDC73 | SNV | Missense_Mutation | | c.1019N>C | p.Val340Ala | p.V340A | Q6P1J9 | protein_coding | tolerated(0.78) | benign(0.007) | TCGA-AN-A0FW-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CDC73 | SNV | Missense_Mutation | novel | c.1034N>A | p.Ser345Tyr | p.S345Y | Q6P1J9 | protein_coding | tolerated(0.13) | probably_damaging(0.949) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD |
CDC73 | SNV | Missense_Mutation | novel | c.947N>T | p.His316Leu | p.H316L | Q6P1J9 | protein_coding | deleterious(0.01) | probably_damaging(0.986) | TCGA-AR-A2LN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | letrozole | SD |
CDC73 | SNV | Missense_Mutation | | c.1247N>A | p.Gly416Asp | p.G416D | Q6P1J9 | protein_coding | deleterious(0.03) | benign(0.03) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
CDC73 | SNV | Missense_Mutation | novel | c.1537N>T | p.Arg513Trp | p.R513W | Q6P1J9 | protein_coding | deleterious(0.02) | possibly_damaging(0.562) | TCGA-BH-A5IZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
CDC73 | SNV | Missense_Mutation | novel | c.72N>C | p.Glu24Asp | p.E24D | Q6P1J9 | protein_coding | tolerated(0.2) | benign(0.003) | TCGA-S3-AA17-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrozole | SD |
CDC73 | SNV | Missense_Mutation | | c.921N>G | p.Phe307Leu | p.F307L | Q6P1J9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD |
CDC73 | SNV | Missense_Mutation | rs878855091 | c.787C>T | p.Arg263Cys | p.R263C | Q6P1J9 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |