Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: C1S

Gene summary for C1S

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

C1S

Gene ID

716

Gene namecomplement C1s
Gene AliasEDSPD2
Cytomap12p13.31
Gene Typeprotein-coding
GO ID

GO:0002250

UniProtAcc

F8WCZ6


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
716C1SAEH-subject2HumanEndometriumAEH5.02e-23-5.13e-01-0.2525
716C1SAEH-subject3HumanEndometriumAEH8.63e-14-4.33e-01-0.2576
716C1SAEH-subject4HumanEndometriumAEH1.15e-09-4.17e-01-0.2657
716C1SAEH-subject5HumanEndometriumAEH1.38e-12-4.86e-01-0.2953
716C1SEEC-subject1HumanEndometriumEEC3.98e-09-4.13e-01-0.2682
716C1SEEC-subject2HumanEndometriumEEC1.12e-08-3.92e-01-0.2607
716C1SEEC-subject3HumanEndometriumEEC1.07e-15-4.68e-01-0.2525
716C1SEEC-subject4HumanEndometriumEEC1.01e-09-4.19e-01-0.2571
716C1SEEC-subject5HumanEndometriumEEC8.69e-18-5.14e-01-0.249
716C1SGSM5276935HumanEndometriumEEC1.38e-30-5.93e-01-0.123
716C1SGSM6177620_NYU_UCEC1_lib1_lib1HumanEndometriumEEC3.99e-22-4.87e-01-0.1869
716C1SGSM6177620_NYU_UCEC1_lib2_lib2HumanEndometriumEEC5.34e-27-5.19e-01-0.1875
716C1SGSM6177620_NYU_UCEC1_lib3_lib3HumanEndometriumEEC4.32e-22-4.66e-01-0.1883
716C1SGSM6177621_NYU_UCEC2_lib1_lib1HumanEndometriumEEC7.67e-31-5.76e-01-0.1934
716C1SGSM6177622_NYU_UCEC3_lib1_lib1HumanEndometriumEEC1.04e-32-5.57e-01-0.1917
716C1SGSM6177622_NYU_UCEC3_lib2_lib2HumanEndometriumEEC7.60e-36-5.59e-01-0.1916
716C1SGSM6177623_NYU_UCEC3_VisHumanEndometriumEEC2.34e-03-1.71e-01-0.1269
716C1SLZE8THumanEsophagusESCC1.22e-071.14e+000.067
716C1SLZE20THumanEsophagusESCC1.31e-02-2.37e-010.0662
716C1SLZE24THumanEsophagusESCC1.50e-04-3.02e-010.0596
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:001097014SkincSCCtransport along microtubule58/4864155/187231.09e-037.24e-0358
GO:003410927SkincSCChomotypic cell-cell adhesion37/486490/187231.22e-037.91e-0337
GO:000808817SkincSCCaxo-dendritic transport32/486475/187231.22e-037.92e-0332
GO:19057109SkincSCCpositive regulation of membrane permeability22/486448/187232.31e-031.35e-0222
GO:00723847SkincSCCorganelle transport along microtubule34/486485/187233.22e-031.76e-0234
GO:19021109SkincSCCpositive regulation of mitochondrial membrane permeability involved in apoptotic process18/486438/187233.64e-031.95e-0218
GO:00324382SkincSCCmelanosome organization14/486428/187235.47e-032.73e-0214
GO:19021087SkincSCCregulation of mitochondrial membrane permeability involved in apoptotic process20/486445/187235.54e-032.74e-0220
GO:00487532SkincSCCpigment granule organization14/486429/187238.08e-033.74e-0214
GO:00482782SkincSCCvesicle docking24/486459/187239.59e-034.30e-0224
GO:00330594SkincSCCcellular pigmentation22/486453/187239.80e-034.33e-0222
GO:00060916StomachGCgeneration of precursor metabolites and energy88/1159490/187236.82e-209.27e-1788
GO:00090606StomachGCaerobic respiration49/1159189/187233.25e-183.54e-1549
GO:00453336StomachGCcellular respiration54/1159230/187237.63e-186.91e-1554
GO:00159806StomachGCenergy derivation by oxidation of organic compounds64/1159318/187232.79e-172.16e-1464
GO:000609111StomachCAG with IMgeneration of precursor metabolites and energy86/1050490/187231.45e-211.93e-1886
GO:000906011StomachCAG with IMaerobic respiration49/1050189/187235.39e-205.75e-1749
GO:004533311StomachCAG with IMcellular respiration54/1050230/187239.39e-208.34e-1754
GO:001598011StomachCAG with IMenergy derivation by oxidation of organic compounds64/1050318/187231.96e-191.49e-1664
GO:000906021StomachCSGaerobic respiration49/1034189/187232.82e-203.12e-1749
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0517126EndometriumAEHCoronavirus disease - COVID-1999/1197232/84655.19e-273.37e-252.47e-2599
hsa05171112EndometriumAEHCoronavirus disease - COVID-1999/1197232/84655.19e-273.37e-252.47e-2599
hsa0517127EndometriumEECCoronavirus disease - COVID-1999/1237232/84657.43e-264.89e-243.65e-2499
hsa0517136EndometriumEECCoronavirus disease - COVID-1999/1237232/84657.43e-264.89e-243.65e-2499
hsa05171211EsophagusESCCCoronavirus disease - COVID-19156/4205232/84653.18e-082.68e-071.37e-07156
hsa051339EsophagusESCCPertussis48/420576/84651.21e-022.77e-021.42e-0248
hsa05171310EsophagusESCCCoronavirus disease - COVID-19156/4205232/84653.18e-082.68e-071.37e-07156
hsa0513314EsophagusESCCPertussis48/420576/84651.21e-022.77e-021.42e-0248
hsa0517114LiverNAFLDCoronavirus disease - COVID-19111/1043232/84651.01e-413.32e-392.67e-39111
hsa04610LiverNAFLDComplement and coagulation cascades35/104386/84652.48e-112.04e-091.64e-0935
hsa0517115LiverNAFLDCoronavirus disease - COVID-19111/1043232/84651.01e-413.32e-392.67e-39111
hsa046101LiverNAFLDComplement and coagulation cascades35/104386/84652.48e-112.04e-091.64e-0935
hsa046102LiverCirrhoticComplement and coagulation cascades48/253086/84654.41e-075.44e-063.35e-0648
hsa046103LiverCirrhoticComplement and coagulation cascades48/253086/84654.41e-075.44e-063.35e-0648
hsa0517142LiverHCCCoronavirus disease - COVID-19167/4020232/84651.50e-144.19e-132.33e-13167
hsa046104LiverHCCComplement and coagulation cascades57/402086/84653.19e-041.45e-038.04e-0457
hsa051332LiverHCCPertussis48/402076/84654.17e-031.27e-027.06e-0348
hsa0517152LiverHCCCoronavirus disease - COVID-19167/4020232/84651.50e-144.19e-132.33e-13167
hsa046105LiverHCCComplement and coagulation cascades57/402086/84653.19e-041.45e-038.04e-0457
hsa051333LiverHCCPertussis48/402076/84654.17e-031.27e-027.06e-0348
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
C1SSNVMissense_Mutationc.1204C>Gp.His402Aspp.H402DP09871protein_codingtolerated(0.09)benign(0.007)TCGA-B6-A0RT-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownSD
C1SinsertionIn_Frame_Insnovelc.387_388insCGCCGCACCACCAAAGAAGGTGCTTGTGTTTGTCAGACAAATp.Ala129_Thr130insArgArgThrThrLysGluGlyAlaCysValCysGlnThrAsnp.A129_T130insRRTTKEGACVCQTNP09871protein_codingTCGA-A2-A0CP-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanSD
C1SdeletionFrame_Shift_Delnovelc.153delNp.Leu52SerfsTer21p.L52Sfs*21P09871protein_codingTCGA-EW-A2FV-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydocetaxelSD
C1SSNVMissense_Mutationnovelc.1810N>Gp.Thr604Alap.T604AP09871protein_codingtolerated(0.61)benign(0.003)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
C1SSNVMissense_Mutationnovelc.1710N>Tp.Trp570Cysp.W570CP09871protein_codingdeleterious(0)probably_damaging(1)TCGA-BI-A0VS-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
C1SSNVMissense_Mutationrs782226018c.362C>Tp.Thr121Metp.T121MP09871protein_codingdeleterious(0)probably_damaging(0.996)TCGA-C5-A1MJ-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
C1SSNVMissense_Mutationc.527G>Tp.Ser176Ilep.S176IP09871protein_codingdeleterious(0)probably_damaging(0.971)TCGA-A6-2679-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
C1SSNVMissense_Mutationrs781887755c.1447C>Tp.Pro483Serp.P483SP09871protein_codingtolerated(0.15)benign(0.18)TCGA-AZ-6598-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
C1SSNVMissense_Mutationnovelc.80N>Cp.Asn27Thrp.N27TP09871protein_codingdeleterious(0.01)possibly_damaging(0.816)TCGA-CA-6717-01Colorectumcolon adenocarcinomaMale<65I/IIChemotherapyoxaliplatinCR
C1SSNVMissense_Mutationrs781845594c.1327N>Ap.Asp443Asnp.D443NP09871protein_codingtolerated(0.55)benign(0.025)TCGA-DM-A1D0-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
716C1SENZYME, PROTEASE, DRUGGABLE GENOMETNT009
716C1SENZYME, PROTEASE, DRUGGABLE GENOMEinhibitor252166820
716C1SENZYME, PROTEASE, DRUGGABLE GENOMECinryzeCINRYZE
716C1SENZYME, PROTEASE, DRUGGABLE GENOMETS01
716C1SENZYME, PROTEASE, DRUGGABLE GENOMEANX005
716C1SENZYME, PROTEASE, DRUGGABLE GENOMEantibody354702279SUTIMLIMAB
716C1SENZYME, PROTEASE, DRUGGABLE GENOMESHP616
716C1SENZYME, PROTEASE, DRUGGABLE GENOMEMBL10878362
716C1SENZYME, PROTEASE, DRUGGABLE GENOMEANTITHROMBIN
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