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Gene: C1D |
Gene summary for C1D |
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Gene information | Species | Human | Gene symbol | C1D | Gene ID | 10438 |
Gene name | C1D nuclear receptor corepressor | |
Gene Alias | LRP1 | |
Cytomap | 2p14 | |
Gene Type | protein-coding | GO ID | GO:0000460 | UniProtAcc | Q13901 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10438 | C1D | LZE2T | Human | Esophagus | ESCC | 1.99e-10 | 1.21e+00 | 0.082 |
10438 | C1D | LZE4T | Human | Esophagus | ESCC | 8.54e-35 | 9.38e-01 | 0.0811 |
10438 | C1D | LZE5T | Human | Esophagus | ESCC | 4.02e-07 | 5.71e-01 | 0.0514 |
10438 | C1D | LZE7T | Human | Esophagus | ESCC | 3.64e-10 | 6.87e-01 | 0.0667 |
10438 | C1D | LZE8T | Human | Esophagus | ESCC | 1.23e-13 | 5.19e-01 | 0.067 |
10438 | C1D | LZE20T | Human | Esophagus | ESCC | 1.98e-07 | 3.58e-01 | 0.0662 |
10438 | C1D | LZE22D1 | Human | Esophagus | HGIN | 8.91e-06 | 2.70e-01 | 0.0595 |
10438 | C1D | LZE22T | Human | Esophagus | ESCC | 3.17e-09 | 6.34e-01 | 0.068 |
10438 | C1D | LZE24T | Human | Esophagus | ESCC | 3.36e-30 | 8.80e-01 | 0.0596 |
10438 | C1D | LZE21T | Human | Esophagus | ESCC | 2.19e-09 | 6.68e-01 | 0.0655 |
10438 | C1D | LZE6T | Human | Esophagus | ESCC | 4.51e-09 | 4.67e-01 | 0.0845 |
10438 | C1D | P1T-E | Human | Esophagus | ESCC | 1.48e-10 | 7.86e-01 | 0.0875 |
10438 | C1D | P2T-E | Human | Esophagus | ESCC | 8.79e-59 | 9.53e-01 | 0.1177 |
10438 | C1D | P4T-E | Human | Esophagus | ESCC | 2.49e-54 | 1.22e+00 | 0.1323 |
10438 | C1D | P5T-E | Human | Esophagus | ESCC | 1.20e-47 | 8.69e-01 | 0.1327 |
10438 | C1D | P8T-E | Human | Esophagus | ESCC | 5.12e-58 | 8.93e-01 | 0.0889 |
10438 | C1D | P9T-E | Human | Esophagus | ESCC | 6.21e-35 | 7.23e-01 | 0.1131 |
10438 | C1D | P10T-E | Human | Esophagus | ESCC | 2.97e-57 | 9.14e-01 | 0.116 |
10438 | C1D | P11T-E | Human | Esophagus | ESCC | 7.69e-27 | 9.68e-01 | 0.1426 |
10438 | C1D | P12T-E | Human | Esophagus | ESCC | 3.61e-58 | 1.05e+00 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004580721 | Liver | HCC | positive regulation of endocytosis | 59/7958 | 100/18723 | 6.35e-04 | 3.93e-03 | 59 |
GO:1902116 | Liver | HCC | negative regulation of organelle assembly | 28/7958 | 41/18723 | 7.54e-04 | 4.55e-03 | 28 |
GO:006049112 | Liver | HCC | regulation of cell projection assembly | 101/7958 | 188/18723 | 1.20e-03 | 6.69e-03 | 101 |
GO:012003212 | Liver | HCC | regulation of plasma membrane bounded cell projection assembly | 100/7958 | 186/18723 | 1.23e-03 | 6.81e-03 | 100 |
GO:00901741 | Liver | HCC | organelle membrane fusion | 63/7958 | 110/18723 | 1.24e-03 | 6.85e-03 | 63 |
GO:00069061 | Liver | HCC | vesicle fusion | 61/7958 | 106/18723 | 1.25e-03 | 6.90e-03 | 61 |
GO:003647511 | Liver | HCC | neuron death in response to oxidative stress | 22/7958 | 31/18723 | 1.27e-03 | 6.92e-03 | 22 |
GO:003647312 | Liver | HCC | cell death in response to oxidative stress | 55/7958 | 95/18723 | 1.76e-03 | 9.12e-03 | 55 |
GO:0061025 | Liver | HCC | membrane fusion | 88/7958 | 163/18723 | 1.98e-03 | 1.00e-02 | 88 |
GO:00016553 | Liver | HCC | urogenital system development | 170/7958 | 338/18723 | 2.15e-03 | 1.08e-02 | 170 |
GO:00219154 | Liver | HCC | neural tube development | 82/7958 | 152/18723 | 2.83e-03 | 1.33e-02 | 82 |
GO:003545921 | Liver | HCC | vesicle cargo loading | 19/7958 | 27/18723 | 3.18e-03 | 1.47e-02 | 19 |
GO:000206422 | Liver | HCC | epithelial cell development | 114/7958 | 220/18723 | 3.19e-03 | 1.47e-02 | 114 |
GO:00018222 | Liver | HCC | kidney development | 148/7958 | 293/18723 | 3.25e-03 | 1.49e-02 | 148 |
GO:00720012 | Liver | HCC | renal system development | 152/7958 | 302/18723 | 3.45e-03 | 1.56e-02 | 152 |
GO:00448271 | Liver | HCC | modulation by host of viral genome replication | 14/7958 | 19/18723 | 5.94e-03 | 2.44e-02 | 14 |
GO:004825921 | Liver | HCC | regulation of receptor-mediated endocytosis | 60/7958 | 110/18723 | 7.12e-03 | 2.84e-02 | 60 |
GO:004826011 | Liver | HCC | positive regulation of receptor-mediated endocytosis | 31/7958 | 52/18723 | 9.52e-03 | 3.60e-02 | 31 |
GO:006145811 | Liver | HCC | reproductive system development | 205/7958 | 427/18723 | 1.16e-02 | 4.27e-02 | 205 |
GO:002261332 | Liver | Cyst | ribonucleoprotein complex biogenesis | 45/496 | 463/18723 | 5.09e-14 | 2.17e-11 | 45 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301810 | Esophagus | HGIN | RNA degradation | 27/1383 | 79/8465 | 7.73e-05 | 9.00e-04 | 7.15e-04 | 27 |
hsa0301815 | Esophagus | HGIN | RNA degradation | 27/1383 | 79/8465 | 7.73e-05 | 9.00e-04 | 7.15e-04 | 27 |
hsa03018 | Liver | Cirrhotic | RNA degradation | 44/2530 | 79/8465 | 1.43e-06 | 1.65e-05 | 1.02e-05 | 44 |
hsa030181 | Liver | Cirrhotic | RNA degradation | 44/2530 | 79/8465 | 1.43e-06 | 1.65e-05 | 1.02e-05 | 44 |
hsa030182 | Liver | HCC | RNA degradation | 58/4020 | 79/8465 | 2.29e-06 | 2.19e-05 | 1.22e-05 | 58 |
hsa030183 | Liver | HCC | RNA degradation | 58/4020 | 79/8465 | 2.29e-06 | 2.19e-05 | 1.22e-05 | 58 |
hsa030189 | Oral cavity | OSCC | RNA degradation | 59/3704 | 79/8465 | 2.05e-08 | 1.91e-07 | 9.70e-08 | 59 |
hsa0301814 | Oral cavity | OSCC | RNA degradation | 59/3704 | 79/8465 | 2.05e-08 | 1.91e-07 | 9.70e-08 | 59 |
hsa0301823 | Oral cavity | LP | RNA degradation | 39/2418 | 79/8465 | 6.98e-05 | 4.38e-04 | 2.83e-04 | 39 |
hsa0301833 | Oral cavity | LP | RNA degradation | 39/2418 | 79/8465 | 6.98e-05 | 4.38e-04 | 2.83e-04 | 39 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C1D | SNV | Missense_Mutation | c.109T>C | p.Ser37Pro | p.S37P | Q13901 | protein_coding | deleterious(0.02) | possibly_damaging(0.798) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
C1D | SNV | Missense_Mutation | c.7N>A | p.Gly3Ser | p.G3S | Q13901 | protein_coding | tolerated(0.9) | benign(0) | TCGA-AZ-6607-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
C1D | SNV | Missense_Mutation | c.32N>T | p.Pro11Leu | p.P11L | Q13901 | protein_coding | deleterious(0) | possibly_damaging(0.661) | TCGA-DM-A28F-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
C1D | SNV | Missense_Mutation | novel | c.4N>A | p.Ala2Thr | p.A2T | Q13901 | protein_coding | deleterious(0.04) | probably_damaging(0.976) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
C1D | SNV | Missense_Mutation | c.192N>G | p.Asn64Lys | p.N64K | Q13901 | protein_coding | deleterious(0) | probably_damaging(0.927) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
C1D | SNV | Missense_Mutation | novel | c.305A>T | p.Asp102Val | p.D102V | Q13901 | protein_coding | deleterious(0) | benign(0.17) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
C1D | insertion | Frame_Shift_Ins | novel | c.222dupA | p.Gly75ArgfsTer3 | p.G75Rfs*3 | Q13901 | protein_coding | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD | ||
C1D | insertion | Frame_Shift_Ins | rs776000138 | c.359_360insA | p.Asn120LysfsTer17 | p.N120Kfs*17 | Q13901 | protein_coding | TCGA-BK-A13B-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
C1D | SNV | Missense_Mutation | novel | c.403N>G | p.Asn135Asp | p.N135D | Q13901 | protein_coding | tolerated(0.3) | benign(0) | TCGA-L4-A4E5-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C1D | SNV | Missense_Mutation | rs775915228 | c.27N>A | p.Asp9Glu | p.D9E | Q13901 | protein_coding | tolerated(0.37) | benign(0.017) | TCGA-CV-5979-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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