Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/RHOA_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/RHOA_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/RHOA_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/RHOA_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/RHOA_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/RHOA_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/RHOA_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/RHOA_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/RHOA_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/RHOA_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/RHOA_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/RHOA_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000815411 | Stomach | CAG with IM | actin polymerization or depolymerization | 30/1050 | 218/18723 | 4.95e-06 | 1.88e-04 | 30 |
GO:004328111 | Stomach | CAG with IM | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 29/1050 | 209/18723 | 6.01e-06 | 2.23e-04 | 29 |
GO:00224071 | Stomach | CAG with IM | regulation of cell-cell adhesion | 49/1050 | 448/18723 | 6.02e-06 | 2.23e-04 | 49 |
GO:004572711 | Stomach | CAG with IM | positive regulation of translation | 22/1050 | 136/18723 | 6.73e-06 | 2.42e-04 | 22 |
GO:004854511 | Stomach | CAG with IM | response to steroid hormone | 40/1050 | 339/18723 | 7.19e-06 | 2.57e-04 | 40 |
GO:003227311 | Stomach | CAG with IM | positive regulation of protein polymerization | 22/1050 | 138/18723 | 8.56e-06 | 2.96e-04 | 22 |
GO:003004111 | Stomach | CAG with IM | actin filament polymerization | 27/1050 | 191/18723 | 8.80e-06 | 2.99e-04 | 27 |
GO:000806411 | Stomach | CAG with IM | regulation of actin polymerization or depolymerization | 26/1050 | 188/18723 | 1.90e-05 | 5.75e-04 | 26 |
GO:003223111 | Stomach | CAG with IM | regulation of actin filament bundle assembly | 18/1050 | 105/18723 | 2.02e-05 | 6.02e-04 | 18 |
GO:190370611 | Stomach | CAG with IM | regulation of hemopoiesis | 41/1050 | 367/18723 | 2.08e-05 | 6.09e-04 | 41 |
GO:003083211 | Stomach | CAG with IM | regulation of actin filament length | 26/1050 | 189/18723 | 2.09e-05 | 6.09e-04 | 26 |
GO:005149511 | Stomach | CAG with IM | positive regulation of cytoskeleton organization | 29/1050 | 226/18723 | 2.73e-05 | 7.70e-04 | 29 |
GO:004586211 | Stomach | CAG with IM | positive regulation of proteolysis | 41/1050 | 372/18723 | 2.85e-05 | 7.99e-04 | 41 |
GO:003083311 | Stomach | CAG with IM | regulation of actin filament polymerization | 24/1050 | 172/18723 | 3.39e-05 | 9.45e-04 | 24 |
GO:000716311 | Stomach | CAG with IM | establishment or maintenance of cell polarity | 28/1050 | 218/18723 | 3.67e-05 | 1.02e-03 | 28 |
GO:004346711 | Stomach | CAG with IM | regulation of generation of precursor metabolites and energy | 20/1050 | 130/18723 | 3.68e-05 | 1.02e-03 | 20 |
GO:003425011 | Stomach | CAG with IM | positive regulation of cellular amide metabolic process | 23/1050 | 162/18723 | 3.71e-05 | 1.02e-03 | 23 |
GO:011002011 | Stomach | CAG with IM | regulation of actomyosin structure organization | 17/1050 | 100/18723 | 3.81e-05 | 1.04e-03 | 17 |
GO:005149211 | Stomach | CAG with IM | regulation of stress fiber assembly | 16/1050 | 91/18723 | 4.18e-05 | 1.11e-03 | 16 |
GO:000836011 | Stomach | CAG with IM | regulation of cell shape | 22/1050 | 154/18723 | 4.94e-05 | 1.27e-03 | 22 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RHOA | SNV | Missense_Mutation | | c.118G>C | p.Glu40Gln | p.E40Q | P61586 | protein_coding | deleterious(0.04) | benign(0.41) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
RHOA | SNV | Missense_Mutation | | c.13N>T | p.Arg5Trp | p.R5W | P61586 | protein_coding | deleterious(0.02) | benign(0.013) | TCGA-AC-A3TM-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | CR |
RHOA | SNV | Missense_Mutation | | c.13N>T | p.Arg5Trp | p.R5W | P61586 | protein_coding | deleterious(0.02) | benign(0.013) | TCGA-BH-A0E0-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
RHOA | SNV | Missense_Mutation | | c.373N>C | p.Glu125Gln | p.E125Q | P61586 | protein_coding | tolerated(0.32) | benign(0.003) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
RHOA | SNV | Missense_Mutation | rs11552761 | c.50N>C | p.Gly17Ala | p.G17A | P61586 | protein_coding | deleterious(0) | benign(0.422) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RHOA | SNV | Missense_Mutation | | c.118N>C | p.Glu40Gln | p.E40Q | P61586 | protein_coding | deleterious(0.04) | benign(0.41) | TCGA-GM-A2DO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | CR |
RHOA | SNV | Missense_Mutation | rs11552761 | c.50N>A | p.Gly17Glu | p.G17E | P61586 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-GM-A3XG-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | CR |
RHOA | insertion | Frame_Shift_Ins | novel | c.561dupA | p.Ser188IlefsTer30 | p.S188Ifs*30 | P61586 | protein_coding | | | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RHOA | insertion | Nonsense_Mutation | novel | c.165_166insAGCAAACTAGATGAGTTCCAAATGTAA | p.Leu55_Ala56insSerLysLeuAspGluPheGlnMetTer | p.L55_A56insSKLDEFQM* | P61586 | protein_coding | | | TCGA-B6-A0IB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
RHOA | SNV | Missense_Mutation | | c.318N>G | p.Phe106Leu | p.F106L | P61586 | protein_coding | deleterious(0.03) | benign(0.324) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD |