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Gene: TRIM2 |
Gene summary for TRIM2 |
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Gene information | Species | Human | Gene symbol | TRIM2 | Gene ID | 23321 |
Gene name | tripartite motif containing 2 | |
Gene Alias | CMT2R | |
Cytomap | 4q31.3 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | Q9C040 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23321 | TRIM2 | CA_HPV_1 | Human | Cervix | CC | 8.99e-09 | -2.78e-01 | 0.0264 |
23321 | TRIM2 | CA_HPV_3 | Human | Cervix | CC | 2.44e-02 | -2.31e-01 | 0.0414 |
23321 | TRIM2 | N_HPV_1 | Human | Cervix | N_HPV | 4.34e-05 | -2.58e-01 | 0.0079 |
23321 | TRIM2 | N_HPV_2 | Human | Cervix | N_HPV | 1.34e-02 | -2.46e-01 | -0.0131 |
23321 | TRIM2 | CCI_1 | Human | Cervix | CC | 4.97e-02 | 6.42e-01 | 0.528 |
23321 | TRIM2 | CCI_2 | Human | Cervix | CC | 9.64e-04 | 7.16e-01 | 0.5249 |
23321 | TRIM2 | H2 | Human | Cervix | HSIL_HPV | 5.94e-07 | 3.49e-01 | 0.0632 |
23321 | TRIM2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.73e-08 | -4.24e-01 | 0.0155 |
23321 | TRIM2 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.80e-19 | 8.02e-01 | -0.1954 |
23321 | TRIM2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.76e-03 | -5.61e-01 | -0.1207 |
23321 | TRIM2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.58e-05 | -5.05e-01 | 0.0528 |
23321 | TRIM2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.56e-02 | -2.87e-01 | 0.294 |
23321 | TRIM2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.94e-08 | 6.73e-01 | 0.281 |
23321 | TRIM2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.14e-05 | -4.08e-01 | 0.3005 |
23321 | TRIM2 | A002-C-010 | Human | Colorectum | FAP | 1.57e-05 | 1.49e-01 | 0.242 |
23321 | TRIM2 | A015-C-203 | Human | Colorectum | FAP | 9.78e-29 | -2.81e-01 | -0.1294 |
23321 | TRIM2 | A014-C-040 | Human | Colorectum | FAP | 2.14e-02 | -2.98e-01 | -0.1184 |
23321 | TRIM2 | A002-C-201 | Human | Colorectum | FAP | 1.50e-08 | -2.20e-01 | 0.0324 |
23321 | TRIM2 | A001-C-119 | Human | Colorectum | FAP | 4.63e-10 | 2.65e-01 | -0.1557 |
23321 | TRIM2 | A001-C-108 | Human | Colorectum | FAP | 3.99e-13 | -1.20e-01 | -0.0272 |
Page: 1 2 3 4 5 6 7 8 9 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190382917 | Endometrium | EEC | positive regulation of cellular protein localization | 67/2168 | 276/18723 | 2.27e-09 | 1.84e-07 | 67 |
GO:003052215 | Endometrium | EEC | intracellular receptor signaling pathway | 65/2168 | 265/18723 | 2.52e-09 | 1.96e-07 | 65 |
GO:005170117 | Endometrium | EEC | biological process involved in interaction with host | 54/2168 | 203/18723 | 2.67e-09 | 2.01e-07 | 54 |
GO:190495116 | Endometrium | EEC | positive regulation of establishment of protein localization | 74/2168 | 319/18723 | 2.90e-09 | 2.10e-07 | 74 |
GO:006145815 | Endometrium | EEC | reproductive system development | 91/2168 | 427/18723 | 4.54e-09 | 3.13e-07 | 91 |
GO:004860814 | Endometrium | EEC | reproductive structure development | 90/2168 | 424/18723 | 6.77e-09 | 4.41e-07 | 90 |
GO:005212617 | Endometrium | EEC | movement in host environment | 47/2168 | 175/18723 | 2.03e-08 | 1.23e-06 | 47 |
GO:000189015 | Endometrium | EEC | placenta development | 40/2168 | 144/18723 | 8.31e-08 | 4.23e-06 | 40 |
GO:005122216 | Endometrium | EEC | positive regulation of protein transport | 66/2168 | 303/18723 | 2.55e-07 | 1.09e-05 | 66 |
GO:005109917 | Endometrium | EEC | positive regulation of binding | 44/2168 | 173/18723 | 3.08e-07 | 1.27e-05 | 44 |
GO:006056013 | Endometrium | EEC | developmental growth involved in morphogenesis | 54/2168 | 234/18723 | 4.60e-07 | 1.78e-05 | 54 |
GO:000170114 | Endometrium | EEC | in utero embryonic development | 75/2168 | 367/18723 | 5.86e-07 | 2.16e-05 | 75 |
GO:200125213 | Endometrium | EEC | positive regulation of chromosome organization | 26/2168 | 82/18723 | 9.70e-07 | 3.31e-05 | 26 |
GO:003315715 | Endometrium | EEC | regulation of intracellular protein transport | 51/2168 | 229/18723 | 2.89e-06 | 8.09e-05 | 51 |
GO:005079217 | Endometrium | EEC | regulation of viral process | 40/2168 | 164/18723 | 3.24e-06 | 8.85e-05 | 40 |
GO:190179617 | Endometrium | EEC | regulation of signal transduction by p53 class mediator | 27/2168 | 93/18723 | 4.07e-06 | 1.06e-04 | 27 |
GO:003238815 | Endometrium | EEC | positive regulation of intracellular transport | 46/2168 | 202/18723 | 4.64e-06 | 1.16e-04 | 46 |
GO:003450413 | Endometrium | EEC | protein localization to nucleus | 60/2168 | 290/18723 | 5.09e-06 | 1.26e-04 | 60 |
GO:003238613 | Endometrium | EEC | regulation of intracellular transport | 67/2168 | 337/18723 | 6.13e-06 | 1.48e-04 | 67 |
GO:007233117 | Endometrium | EEC | signal transduction by p53 class mediator | 39/2168 | 163/18723 | 7.00e-06 | 1.63e-04 | 39 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRIM2 | SNV | Missense_Mutation | novel | c.1667N>T | p.Ser556Phe | p.S556F | Q9C040 | protein_coding | deleterious(0) | benign(0.352) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
TRIM2 | SNV | Missense_Mutation | novel | c.230A>G | p.Tyr77Cys | p.Y77C | Q9C040 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AC-A7VC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TRIM2 | SNV | Missense_Mutation | rs780090814 | c.1793G>T | p.Gly598Val | p.G598V | Q9C040 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR |
TRIM2 | insertion | Frame_Shift_Ins | novel | c.211_212insCTCACCCAGGCTGGAGTGC | p.Glu71AlafsTer62 | p.E71Afs*62 | Q9C040 | protein_coding | TCGA-A8-A09D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | ||
TRIM2 | deletion | Frame_Shift_Del | novel | c.1234delN | p.Lys412ArgfsTer21 | p.K412Rfs*21 | Q9C040 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
TRIM2 | SNV | Missense_Mutation | rs759524701 | c.1876G>A | p.Val626Met | p.V626M | Q9C040 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TRIM2 | SNV | Missense_Mutation | rs754843842 | c.733N>T | p.Arg245Cys | p.R245C | Q9C040 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TRIM2 | SNV | Missense_Mutation | novel | c.1724N>A | p.Ile575Asn | p.I575N | Q9C040 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AA-3979-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TRIM2 | SNV | Missense_Mutation | novel | c.225N>T | p.Gln75His | p.Q75H | Q9C040 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TRIM2 | SNV | Missense_Mutation | novel | c.1183N>A | p.Glu395Lys | p.E395K | Q9C040 | protein_coding | tolerated(0.23) | benign(0.253) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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