Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/RP9_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/RP9_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/RP9_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/RP9_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003434114 | Oral cavity | LP | response to interferon-gamma | 57/4623 | 141/18723 | 2.63e-05 | 4.21e-04 | 57 |
GO:0051099110 | Oral cavity | LP | positive regulation of binding | 67/4623 | 173/18723 | 2.86e-05 | 4.51e-04 | 67 |
GO:000675319 | Oral cavity | LP | nucleoside phosphate metabolic process | 161/4623 | 497/18723 | 5.31e-05 | 7.39e-04 | 161 |
GO:0009117110 | Oral cavity | LP | nucleotide metabolic process | 158/4623 | 489/18723 | 7.17e-05 | 9.49e-04 | 158 |
GO:007134612 | Oral cavity | LP | cellular response to interferon-gamma | 48/4623 | 118/18723 | 9.16e-05 | 1.15e-03 | 48 |
GO:000195911 | Oral cavity | LP | regulation of cytokine-mediated signaling pathway | 58/4623 | 150/18723 | 1.00e-04 | 1.24e-03 | 58 |
GO:001908212 | Oral cavity | LP | viral protein processing | 17/4623 | 29/18723 | 1.02e-04 | 1.24e-03 | 17 |
GO:004508811 | Oral cavity | LP | regulation of innate immune response | 78/4623 | 218/18723 | 1.57e-04 | 1.78e-03 | 78 |
GO:006075911 | Oral cavity | LP | regulation of response to cytokine stimulus | 61/4623 | 162/18723 | 1.61e-04 | 1.81e-03 | 61 |
GO:000283112 | Oral cavity | LP | regulation of response to biotic stimulus | 109/4623 | 327/18723 | 2.45e-04 | 2.60e-03 | 109 |
GO:00066135 | Oral cavity | LP | cotranslational protein targeting to membrane | 17/4623 | 31/18723 | 3.09e-04 | 3.15e-03 | 17 |
GO:006033312 | Oral cavity | LP | interferon-gamma-mediated signaling pathway | 15/4623 | 27/18723 | 5.80e-04 | 5.35e-03 | 15 |
GO:000641417 | Oral cavity | LP | translational elongation | 25/4623 | 55/18723 | 6.27e-04 | 5.71e-03 | 25 |
GO:190129315 | Oral cavity | LP | nucleoside phosphate biosynthetic process | 84/4623 | 256/18723 | 1.98e-03 | 1.47e-02 | 84 |
GO:000196111 | Oral cavity | LP | positive regulation of cytokine-mediated signaling pathway | 22/4623 | 50/18723 | 2.18e-03 | 1.58e-02 | 22 |
GO:000916515 | Oral cavity | LP | nucleotide biosynthetic process | 83/4623 | 254/18723 | 2.38e-03 | 1.71e-02 | 83 |
GO:006076011 | Oral cavity | LP | positive regulation of response to cytokine stimulus | 24/4623 | 57/18723 | 2.88e-03 | 2.00e-02 | 24 |
GO:00066142 | Oral cavity | LP | SRP-dependent cotranslational protein targeting to membrane | 13/4623 | 26/18723 | 4.62e-03 | 2.93e-02 | 13 |
GO:00506911 | Oral cavity | LP | regulation of defense response to virus by host | 18/4623 | 41/18723 | 5.51e-03 | 3.33e-02 | 18 |
GO:00506881 | Oral cavity | LP | regulation of defense response to virus | 27/4623 | 69/18723 | 5.55e-03 | 3.35e-02 | 27 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RP9 | SNV | Missense_Mutation | | c.401N>C | p.Arg134Thr | p.R134T | Q8TA86 | protein_coding | deleterious(0.02) | probably_damaging(0.969) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
RP9 | SNV | Missense_Mutation | | c.169C>A | p.Pro57Thr | p.P57T | Q8TA86 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RP9 | insertion | Frame_Shift_Ins | novel | c.363_364insAAAAGGATCAATAACAAACGGG | p.Phe122LysfsTer24 | p.F122Kfs*24 | Q8TA86 | protein_coding | | | TCGA-A8-A07G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR |
RP9 | SNV | Missense_Mutation | | c.319N>A | p.Arg107Ser | p.R107S | Q8TA86 | protein_coding | deleterious(0) | possibly_damaging(0.871) | TCGA-UC-A7PF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RP9 | SNV | Missense_Mutation | | c.283C>T | p.Pro95Ser | p.P95S | Q8TA86 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RP9 | SNV | Missense_Mutation | | c.365N>C | p.Phe122Ser | p.F122S | Q8TA86 | protein_coding | deleterious(0) | benign(0.173) | TCGA-DM-A1D6-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RP9 | SNV | Missense_Mutation | | c.663N>C | p.Glu221Asp | p.E221D | Q8TA86 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RP9 | SNV | Missense_Mutation | | c.283C>T | p.Pro95Ser | p.P95S | Q8TA86 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RP9 | SNV | Missense_Mutation | novel | c.227G>T | p.Gly76Val | p.G76V | Q8TA86 | protein_coding | deleterious(0) | probably_damaging(0.948) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RP9 | SNV | Missense_Mutation | rs760221836 | c.328C>T | p.Arg110Cys | p.R110C | Q8TA86 | protein_coding | deleterious(0.05) | benign(0.02) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |