Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/PRKCI_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/PRKCI_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/PRKCI_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/PRKCI_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/PRKCI_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/PRKCI_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/PRKCI_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/PRKCI_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19012158 | Prostate | BPH | negative regulation of neuron death | 53/3107 | 208/18723 | 6.87e-04 | 4.58e-03 | 53 |
GO:19040353 | Prostate | BPH | regulation of epithelial cell apoptotic process | 28/3107 | 96/18723 | 1.46e-03 | 8.69e-03 | 28 |
GO:00510924 | Prostate | BPH | positive regulation of NF-kappaB transcription factor activity | 40/3107 | 152/18723 | 1.54e-03 | 9.08e-03 | 40 |
GO:00510916 | Prostate | BPH | positive regulation of DNA-binding transcription factor activity | 62/3107 | 260/18723 | 1.58e-03 | 9.23e-03 | 62 |
GO:00350887 | Prostate | BPH | establishment or maintenance of apical/basal cell polarity | 17/3107 | 49/18723 | 1.60e-03 | 9.32e-03 | 17 |
GO:00612457 | Prostate | BPH | establishment or maintenance of bipolar cell polarity | 17/3107 | 49/18723 | 1.60e-03 | 9.32e-03 | 17 |
GO:00990726 | Prostate | BPH | regulation of postsynaptic membrane neurotransmitter receptor levels | 20/3107 | 62/18723 | 1.80e-03 | 1.03e-02 | 20 |
GO:00481945 | Prostate | BPH | Golgi vesicle budding | 6/3107 | 10/18723 | 2.38e-03 | 1.29e-02 | 6 |
GO:00611624 | Prostate | BPH | establishment of monopolar cell polarity | 10/3107 | 24/18723 | 3.21e-03 | 1.67e-02 | 10 |
GO:00451977 | Prostate | BPH | establishment or maintenance of epithelial cell apical/basal polarity | 15/3107 | 44/18723 | 3.59e-03 | 1.83e-02 | 15 |
GO:00420634 | Prostate | BPH | gliogenesis | 68/3107 | 301/18723 | 4.06e-03 | 2.02e-02 | 68 |
GO:00613393 | Prostate | BPH | establishment or maintenance of monopolar cell polarity | 10/3107 | 25/18723 | 4.57e-03 | 2.19e-02 | 10 |
GO:00350892 | Prostate | BPH | establishment of apical/basal cell polarity | 9/3107 | 22/18723 | 5.92e-03 | 2.73e-02 | 9 |
GO:00072195 | Prostate | BPH | Notch signaling pathway | 41/3107 | 172/18723 | 8.95e-03 | 3.83e-02 | 41 |
GO:00435244 | Prostate | BPH | negative regulation of neuron apoptotic process | 35/3107 | 145/18723 | 1.23e-02 | 4.94e-02 | 35 |
GO:000701519 | Prostate | Tumor | actin filament organization | 142/3246 | 442/18723 | 1.40e-14 | 1.89e-12 | 142 |
GO:004819314 | Prostate | Tumor | Golgi vesicle transport | 105/3246 | 296/18723 | 3.55e-14 | 4.33e-12 | 105 |
GO:000660519 | Prostate | Tumor | protein targeting | 109/3246 | 314/18723 | 6.11e-14 | 7.30e-12 | 109 |
GO:190382919 | Prostate | Tumor | positive regulation of cellular protein localization | 97/3246 | 276/18723 | 6.35e-13 | 6.58e-11 | 97 |
GO:000716317 | Prostate | Tumor | establishment or maintenance of cell polarity | 74/3246 | 218/18723 | 2.00e-09 | 8.86e-08 | 74 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRKCI | SNV | Missense_Mutation | | c.1540N>C | p.Ala514Pro | p.A514P | P41743 | protein_coding | tolerated(0.21) | benign(0.437) | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD |
PRKCI | SNV | Missense_Mutation | | c.1745N>G | p.Phe582Cys | p.F582C | P41743 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
PRKCI | deletion | Frame_Shift_Del | novel | c.1551delN | p.Gly518AspfsTer12 | p.G518Dfs*12 | P41743 | protein_coding | | | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
PRKCI | SNV | Missense_Mutation | novel | c.238G>A | p.Val80Ile | p.V80I | P41743 | protein_coding | tolerated(1) | benign(0.024) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PRKCI | SNV | Missense_Mutation | novel | c.697G>C | p.Glu233Gln | p.E233Q | P41743 | protein_coding | tolerated(0.1) | benign(0.003) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
PRKCI | SNV | Missense_Mutation | | c.862N>C | p.Glu288Gln | p.E288Q | P41743 | protein_coding | tolerated(0.06) | possibly_damaging(0.837) | TCGA-EK-A2RC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PRKCI | SNV | Missense_Mutation | | c.318N>G | p.Phe106Leu | p.F106L | P41743 | protein_coding | tolerated(0.09) | probably_damaging(0.999) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PRKCI | SNV | Missense_Mutation | | c.157N>C | p.Glu53Gln | p.E53Q | P41743 | protein_coding | tolerated(0.11) | possibly_damaging(0.751) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PRKCI | SNV | Missense_Mutation | | c.1376N>T | p.Ser459Phe | p.S459F | P41743 | protein_coding | tolerated(0.06) | possibly_damaging(0.878) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PRKCI | SNV | Missense_Mutation | | c.880G>A | p.Glu294Lys | p.E294K | P41743 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-MY-A5BD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5584 | PRKCI | KINASE, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | | GSK-269962A | GSK-269962A | |
5584 | PRKCI | KINASE, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | | ILORASERTIB | ILORASERTIB | |
5584 | PRKCI | KINASE, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL608533 | MIDOSTAURIN | |
5584 | PRKCI | KINASE, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | SOPHORETIN | QUERCETIN | |
5584 | PRKCI | KINASE, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL3545332 | CEP-2563 | |
5584 | PRKCI | KINASE, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 135652717 | STAUROSPORINE | |
5584 | PRKCI | KINASE, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL574737 | UCN-01 | |
5584 | PRKCI | KINASE, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | | SOTRASTAURIN | SOTRASTAURIN | |
5584 | PRKCI | KINASE, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL565612 | SOTRASTAURIN | |
5584 | PRKCI | KINASE, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, DRUGGABLE GENOME, ENZYME | | INGENOL MEBUTATE | | |