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Gene: NUCKS1 |
Gene summary for NUCKS1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | NUCKS1 | Gene ID | 64710 |
Gene name | nuclear casein kinase and cyclin dependent kinase substrate 1 | |
Gene Alias | JC7 | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0000724 | UniProtAcc | Q9H1E3 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64710 | NUCKS1 | GSM4909281 | Human | Breast | IDC | 5.20e-19 | 5.54e-01 | 0.21 |
64710 | NUCKS1 | GSM4909282 | Human | Breast | IDC | 4.09e-26 | 5.97e-01 | -0.0288 |
64710 | NUCKS1 | GSM4909285 | Human | Breast | IDC | 7.37e-61 | 8.52e-01 | 0.21 |
64710 | NUCKS1 | GSM4909287 | Human | Breast | IDC | 1.30e-37 | 6.41e-01 | 0.2057 |
64710 | NUCKS1 | GSM4909290 | Human | Breast | IDC | 2.50e-23 | 6.22e-01 | 0.2096 |
64710 | NUCKS1 | GSM4909291 | Human | Breast | IDC | 2.01e-08 | 4.09e-01 | 0.1753 |
64710 | NUCKS1 | GSM4909293 | Human | Breast | IDC | 4.36e-86 | 9.29e-01 | 0.1581 |
64710 | NUCKS1 | GSM4909294 | Human | Breast | IDC | 4.64e-14 | 1.97e-01 | 0.2022 |
64710 | NUCKS1 | GSM4909296 | Human | Breast | IDC | 8.72e-18 | 1.79e-01 | 0.1524 |
64710 | NUCKS1 | GSM4909297 | Human | Breast | IDC | 8.69e-31 | 1.54e-01 | 0.1517 |
64710 | NUCKS1 | GSM4909298 | Human | Breast | IDC | 3.24e-27 | 6.20e-01 | 0.1551 |
64710 | NUCKS1 | GSM4909299 | Human | Breast | IDC | 5.41e-03 | 2.96e-01 | 0.035 |
64710 | NUCKS1 | GSM4909301 | Human | Breast | IDC | 1.51e-13 | 4.03e-01 | 0.1577 |
64710 | NUCKS1 | GSM4909302 | Human | Breast | IDC | 5.74e-26 | 4.87e-01 | 0.1545 |
64710 | NUCKS1 | GSM4909305 | Human | Breast | IDC | 3.64e-04 | 3.29e-01 | 0.0436 |
64710 | NUCKS1 | GSM4909306 | Human | Breast | IDC | 2.25e-26 | 5.82e-01 | 0.1564 |
64710 | NUCKS1 | GSM4909307 | Human | Breast | IDC | 5.99e-25 | 5.58e-01 | 0.1569 |
64710 | NUCKS1 | GSM4909308 | Human | Breast | IDC | 5.29e-19 | 5.32e-01 | 0.158 |
64710 | NUCKS1 | GSM4909309 | Human | Breast | IDC | 2.55e-12 | 3.24e-01 | 0.0483 |
64710 | NUCKS1 | GSM4909311 | Human | Breast | IDC | 3.19e-44 | -1.18e-01 | 0.1534 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000632510 | Oral cavity | OSCC | chromatin organization | 190/7305 | 409/18723 | 1.17e-03 | 5.97e-03 | 190 |
GO:00101652 | Oral cavity | OSCC | response to X-ray | 22/7305 | 33/18723 | 1.19e-03 | 6.03e-03 | 22 |
GO:004259316 | Oral cavity | OSCC | glucose homeostasis | 125/7305 | 258/18723 | 1.21e-03 | 6.08e-03 | 125 |
GO:003350016 | Oral cavity | OSCC | carbohydrate homeostasis | 125/7305 | 259/18723 | 1.44e-03 | 6.97e-03 | 125 |
GO:00466263 | Oral cavity | OSCC | regulation of insulin receptor signaling pathway | 38/7305 | 66/18723 | 1.70e-03 | 8.07e-03 | 38 |
GO:19000763 | Oral cavity | OSCC | regulation of cellular response to insulin stimulus | 37/7305 | 64/18723 | 1.76e-03 | 8.31e-03 | 37 |
GO:00447887 | Oral cavity | OSCC | modulation by host of viral process | 20/7305 | 30/18723 | 1.99e-03 | 9.23e-03 | 20 |
GO:19000783 | Oral cavity | OSCC | positive regulation of cellular response to insulin stimulus | 17/7305 | 25/18723 | 3.16e-03 | 1.36e-02 | 17 |
GO:00439232 | Oral cavity | OSCC | positive regulation by host of viral transcription | 12/7305 | 16/18723 | 3.83e-03 | 1.57e-02 | 12 |
GO:0000725 | Oral cavity | OSCC | recombinational repair | 70/7305 | 140/18723 | 5.22e-03 | 2.03e-02 | 70 |
GO:0000724 | Oral cavity | OSCC | double-strand break repair via homologous recombination | 69/7305 | 138/18723 | 5.52e-03 | 2.14e-02 | 69 |
GO:00448274 | Oral cavity | OSCC | modulation by host of viral genome replication | 13/7305 | 19/18723 | 9.07e-03 | 3.26e-02 | 13 |
GO:0016032110 | Oral cavity | LP | viral process | 211/4623 | 415/18723 | 4.06e-31 | 3.18e-28 | 211 |
GO:0019058110 | Oral cavity | LP | viral life cycle | 161/4623 | 317/18723 | 5.99e-24 | 2.21e-21 | 161 |
GO:0019079110 | Oral cavity | LP | viral genome replication | 73/4623 | 131/18723 | 2.78e-14 | 3.11e-12 | 73 |
GO:0044403110 | Oral cavity | LP | biological process involved in symbiotic interaction | 130/4623 | 290/18723 | 4.23e-14 | 4.64e-12 | 130 |
GO:001908015 | Oral cavity | LP | viral gene expression | 53/4623 | 94/18723 | 5.06e-11 | 3.14e-09 | 53 |
GO:0051098110 | Oral cavity | LP | regulation of binding | 140/4623 | 363/18723 | 2.47e-09 | 1.10e-07 | 140 |
GO:001021216 | Oral cavity | LP | response to ionizing radiation | 64/4623 | 148/18723 | 5.60e-07 | 1.51e-05 | 64 |
GO:007121417 | Oral cavity | LP | cellular response to abiotic stimulus | 121/4623 | 331/18723 | 8.45e-07 | 2.20e-05 | 121 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NUCKS1 | SNV | Missense_Mutation | c.256C>T | p.His86Tyr | p.H86Y | Q9H1E3 | protein_coding | tolerated(0.46) | benign(0.091) | TCGA-BH-A0DX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
NUCKS1 | SNV | Missense_Mutation | rs771629435 | c.635C>T | p.Pro212Leu | p.P212L | Q9H1E3 | protein_coding | tolerated(0.29) | benign(0.061) | TCGA-GM-A2DD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | CR |
NUCKS1 | SNV | Missense_Mutation | rs754971187 | c.274N>A | p.Gln92Lys | p.Q92K | Q9H1E3 | protein_coding | tolerated(1) | benign(0.444) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NUCKS1 | SNV | Missense_Mutation | novel | c.218C>A | p.Ser73Tyr | p.S73Y | Q9H1E3 | protein_coding | deleterious(0.02) | probably_damaging(0.983) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NUCKS1 | SNV | Missense_Mutation | rs762593780 | c.89N>T | p.Ser30Leu | p.S30L | Q9H1E3 | protein_coding | tolerated(0.15) | possibly_damaging(0.572) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
NUCKS1 | SNV | Missense_Mutation | rs551812416 | c.572N>A | p.Arg191His | p.R191H | Q9H1E3 | protein_coding | deleterious(0.05) | benign(0.001) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NUCKS1 | SNV | Missense_Mutation | novel | c.295N>A | p.Ala99Thr | p.A99T | Q9H1E3 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NUCKS1 | SNV | Missense_Mutation | c.98N>T | p.Pro33Leu | p.P33L | Q9H1E3 | protein_coding | deleterious(0) | possibly_damaging(0.535) | TCGA-AP-A0LG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NUCKS1 | SNV | Missense_Mutation | rs758268939 | c.446N>T | p.Ser149Leu | p.S149L | Q9H1E3 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-B5-A0JR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NUCKS1 | SNV | Missense_Mutation | novel | c.343N>A | p.Glu115Lys | p.E115K | Q9H1E3 | protein_coding | tolerated(0.1) | possibly_damaging(0.452) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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