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Gene: NR1H2 |
Gene summary for NR1H2 |
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Gene information | Species | Human | Gene symbol | NR1H2 | Gene ID | 7376 |
Gene name | nuclear receptor subfamily 1 group H member 2 | |
Gene Alias | LXR-b | |
Cytomap | 19q13.33 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P55055 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7376 | NR1H2 | LZE2D | Human | Esophagus | HGIN | 8.09e-03 | 2.42e-01 | 0.0642 |
7376 | NR1H2 | LZE4T | Human | Esophagus | ESCC | 4.08e-14 | 3.38e-01 | 0.0811 |
7376 | NR1H2 | LZE7T | Human | Esophagus | ESCC | 5.33e-10 | 5.36e-01 | 0.0667 |
7376 | NR1H2 | LZE8T | Human | Esophagus | ESCC | 3.25e-15 | 3.16e-01 | 0.067 |
7376 | NR1H2 | LZE20T | Human | Esophagus | ESCC | 1.52e-05 | 1.66e-01 | 0.0662 |
7376 | NR1H2 | LZE22D1 | Human | Esophagus | HGIN | 8.83e-03 | 1.55e-01 | 0.0595 |
7376 | NR1H2 | LZE22T | Human | Esophagus | ESCC | 4.29e-05 | 5.37e-01 | 0.068 |
7376 | NR1H2 | LZE24T | Human | Esophagus | ESCC | 7.40e-30 | 8.11e-01 | 0.0596 |
7376 | NR1H2 | LZE21T | Human | Esophagus | ESCC | 1.46e-02 | 2.08e-01 | 0.0655 |
7376 | NR1H2 | LZE6T | Human | Esophagus | ESCC | 2.91e-05 | 4.79e-01 | 0.0845 |
7376 | NR1H2 | P1T-E | Human | Esophagus | ESCC | 4.90e-14 | 5.47e-01 | 0.0875 |
7376 | NR1H2 | P2T-E | Human | Esophagus | ESCC | 1.58e-31 | 5.36e-01 | 0.1177 |
7376 | NR1H2 | P4T-E | Human | Esophagus | ESCC | 1.08e-26 | 5.69e-01 | 0.1323 |
7376 | NR1H2 | P5T-E | Human | Esophagus | ESCC | 2.44e-14 | 1.89e-01 | 0.1327 |
7376 | NR1H2 | P8T-E | Human | Esophagus | ESCC | 1.55e-64 | 1.33e+00 | 0.0889 |
7376 | NR1H2 | P9T-E | Human | Esophagus | ESCC | 5.81e-22 | 5.24e-01 | 0.1131 |
7376 | NR1H2 | P10T-E | Human | Esophagus | ESCC | 8.68e-43 | 7.94e-01 | 0.116 |
7376 | NR1H2 | P11T-E | Human | Esophagus | ESCC | 3.25e-27 | 8.98e-01 | 0.1426 |
7376 | NR1H2 | P12T-E | Human | Esophagus | ESCC | 4.34e-25 | 4.13e-01 | 0.1122 |
7376 | NR1H2 | P15T-E | Human | Esophagus | ESCC | 2.91e-32 | 6.83e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007134614 | Thyroid | ATC | cellular response to interferon-gamma | 52/6293 | 118/18723 | 1.14e-02 | 4.06e-02 | 52 |
GO:000690712 | Thyroid | ATC | pinocytosis | 13/6293 | 22/18723 | 1.25e-02 | 4.38e-02 | 13 |
GO:000165912 | Thyroid | ATC | temperature homeostasis | 73/6293 | 174/18723 | 1.29e-02 | 4.51e-02 | 73 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa049318 | Esophagus | ESCC | Insulin resistance | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa0493113 | Esophagus | ESCC | Insulin resistance | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa0493121 | Liver | HCC | Insulin resistance | 77/4020 | 108/8465 | 3.89e-07 | 4.46e-06 | 2.48e-06 | 77 |
hsa0493131 | Liver | HCC | Insulin resistance | 77/4020 | 108/8465 | 3.89e-07 | 4.46e-06 | 2.48e-06 | 77 |
hsa049317 | Oral cavity | OSCC | Insulin resistance | 60/3704 | 108/8465 | 8.66e-03 | 1.97e-02 | 1.00e-02 | 60 |
hsa0493112 | Oral cavity | OSCC | Insulin resistance | 60/3704 | 108/8465 | 8.66e-03 | 1.97e-02 | 1.00e-02 | 60 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NR1H2 | SNV | Missense_Mutation | c.796N>T | p.Arg266Cys | p.R266C | P55055 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A8-A08Z-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
NR1H2 | SNV | Missense_Mutation | rs140558724 | c.643N>A | p.Glu215Lys | p.E215K | P55055 | protein_coding | tolerated(0.74) | benign(0.029) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NR1H2 | SNV | Missense_Mutation | rs750204613 | c.376N>T | p.Arg126Trp | p.R126W | P55055 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-C8-A12M-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NR1H2 | SNV | Missense_Mutation | c.1049A>T | p.Asn350Ile | p.N350I | P55055 | protein_coding | deleterious(0) | possibly_damaging(0.881) | TCGA-E2-A15E-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
NR1H2 | SNV | Missense_Mutation | c.253N>A | p.Glu85Lys | p.E85K | P55055 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
NR1H2 | SNV | Missense_Mutation | rs763608025 | c.788N>A | p.Arg263His | p.R263H | P55055 | protein_coding | tolerated(0.1) | benign(0.086) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NR1H2 | SNV | Missense_Mutation | c.254N>C | p.Glu85Ala | p.E85A | P55055 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
NR1H2 | SNV | Missense_Mutation | rs771140870 | c.341N>A | p.Ser114Asn | p.S114N | P55055 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-MA-AA43-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
NR1H2 | SNV | Missense_Mutation | c.659C>T | p.Thr220Ile | p.T220I | P55055 | protein_coding | deleterious(0.02) | benign(0.302) | TCGA-MY-A5BF-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | CR | |
NR1H2 | SNV | Missense_Mutation | rs772224466 | c.67N>A | p.Ala23Thr | p.A23T | P55055 | protein_coding | tolerated(0.76) | benign(0) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7376 | NR1H2 | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME | agonist | 135651470 | DESMOSTEROL | |
7376 | NR1H2 | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME | agonist | 223366058 | ||
7376 | NR1H2 | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME | GW3965 | CHEMBL59030 | 18800767 | |
7376 | NR1H2 | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME | agonist | 135651391 | ||
7376 | NR1H2 | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME | DESMOSTEROL | DESMOSTEROL | 23910990 | |
7376 | NR1H2 | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME | agonist | 135650496 | ||
7376 | NR1H2 | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME | VTB-38543 | |||
7376 | NR1H2 | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME | agonist | 135651390 | ||
7376 | NR1H2 | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME | agonist | CHEMBL3545418 | BMS-779788 | |
7376 | NR1H2 | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME | agonist | CHEMBL3545238 | CS-8080 |
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