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Gene: NNMT |
Gene summary for NNMT |
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Gene information | Species | Human | Gene symbol | NNMT | Gene ID | 4837 |
Gene name | nicotinamide N-methyltransferase | |
Gene Alias | NNMT | |
Cytomap | 11q23.2 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | P40261 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4837 | NNMT | GSM4909277 | Human | Breast | Precancer | 1.76e-04 | 6.98e-01 | 0.0177 |
4837 | NNMT | GSM4909285 | Human | Breast | IDC | 8.44e-15 | -3.98e-01 | 0.21 |
4837 | NNMT | GSM4909286 | Human | Breast | IDC | 6.26e-19 | -4.32e-01 | 0.1081 |
4837 | NNMT | GSM4909290 | Human | Breast | IDC | 1.30e-02 | -3.49e-01 | 0.2096 |
4837 | NNMT | GSM4909291 | Human | Breast | IDC | 1.23e-02 | -3.65e-01 | 0.1753 |
4837 | NNMT | GSM4909293 | Human | Breast | IDC | 3.43e-13 | -3.03e-01 | 0.1581 |
4837 | NNMT | GSM4909294 | Human | Breast | IDC | 1.58e-10 | -3.20e-01 | 0.2022 |
4837 | NNMT | GSM4909296 | Human | Breast | IDC | 5.87e-11 | -3.46e-01 | 0.1524 |
4837 | NNMT | GSM4909297 | Human | Breast | IDC | 5.33e-07 | -2.78e-01 | 0.1517 |
4837 | NNMT | GSM4909298 | Human | Breast | IDC | 1.08e-10 | -3.76e-01 | 0.1551 |
4837 | NNMT | GSM4909299 | Human | Breast | IDC | 2.06e-03 | 3.86e-01 | 0.035 |
4837 | NNMT | GSM4909301 | Human | Breast | IDC | 4.69e-19 | -4.26e-01 | 0.1577 |
4837 | NNMT | GSM4909304 | Human | Breast | IDC | 9.83e-13 | -3.89e-01 | 0.1636 |
4837 | NNMT | GSM4909307 | Human | Breast | IDC | 1.73e-07 | -3.24e-01 | 0.1569 |
4837 | NNMT | GSM4909308 | Human | Breast | IDC | 3.49e-10 | -4.18e-01 | 0.158 |
4837 | NNMT | GSM4909309 | Human | Breast | IDC | 1.06e-05 | 4.38e-01 | 0.0483 |
4837 | NNMT | GSM4909311 | Human | Breast | IDC | 1.19e-16 | -3.77e-01 | 0.1534 |
4837 | NNMT | GSM4909312 | Human | Breast | IDC | 5.96e-23 | -4.30e-01 | 0.1552 |
4837 | NNMT | GSM4909315 | Human | Breast | IDC | 6.54e-18 | -4.33e-01 | 0.21 |
4837 | NNMT | GSM4909316 | Human | Breast | IDC | 3.34e-04 | -4.35e-01 | 0.21 |
Page: 1 2 3 4 5 6 7 8 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000599610 | Skin | cSCC | monosaccharide metabolic process | 85/4864 | 257/18723 | 6.43e-03 | 3.14e-02 | 85 |
GO:00067672 | Skin | cSCC | water-soluble vitamin metabolic process | 24/4864 | 59/18723 | 9.59e-03 | 4.30e-02 | 24 |
GO:000600610 | Skin | cSCC | glucose metabolic process | 66/4864 | 196/18723 | 9.75e-03 | 4.32e-02 | 66 |
GO:003106014 | Skin | cSCC | regulation of histone methylation | 27/4864 | 69/18723 | 1.13e-02 | 4.92e-02 | 27 |
GO:001657017 | Thyroid | ATC | histone modification | 243/6293 | 463/18723 | 2.23e-17 | 2.27e-15 | 243 |
GO:001820516 | Thyroid | ATC | peptidyl-lysine modification | 193/6293 | 376/18723 | 6.92e-13 | 3.06e-11 | 193 |
GO:003105616 | Thyroid | ATC | regulation of histone modification | 85/6293 | 152/18723 | 1.23e-08 | 2.55e-07 | 85 |
GO:0006753111 | Thyroid | ATC | nucleoside phosphate metabolic process | 219/6293 | 497/18723 | 5.92e-07 | 8.29e-06 | 219 |
GO:0009117112 | Thyroid | ATC | nucleotide metabolic process | 215/6293 | 489/18723 | 9.09e-07 | 1.20e-05 | 215 |
GO:003560114 | Thyroid | ATC | protein deacylation | 61/6293 | 112/18723 | 4.37e-06 | 4.79e-05 | 61 |
GO:000647614 | Thyroid | ATC | protein deacetylation | 56/6293 | 101/18723 | 5.15e-06 | 5.57e-05 | 56 |
GO:003110023 | Thyroid | ATC | animal organ regeneration | 44/6293 | 76/18723 | 1.18e-05 | 1.15e-04 | 44 |
GO:001931814 | Thyroid | ATC | hexose metabolic process | 111/6293 | 237/18723 | 1.51e-05 | 1.41e-04 | 111 |
GO:009873213 | Thyroid | ATC | macromolecule deacylation | 61/6293 | 116/18723 | 1.89e-05 | 1.72e-04 | 61 |
GO:000599615 | Thyroid | ATC | monosaccharide metabolic process | 118/6293 | 257/18723 | 2.56e-05 | 2.20e-04 | 118 |
GO:000600616 | Thyroid | ATC | glucose metabolic process | 93/6293 | 196/18723 | 3.85e-05 | 3.14e-04 | 93 |
GO:001657115 | Thyroid | ATC | histone methylation | 69/6293 | 141/18723 | 1.14e-04 | 8.16e-04 | 69 |
GO:000647916 | Thyroid | ATC | protein methylation | 85/6293 | 181/18723 | 1.27e-04 | 9.00e-04 | 85 |
GO:000821316 | Thyroid | ATC | protein alkylation | 85/6293 | 181/18723 | 1.27e-04 | 9.00e-04 | 85 |
GO:003109932 | Thyroid | ATC | regeneration | 91/6293 | 198/18723 | 1.95e-04 | 1.31e-03 | 91 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NNMT | deletion | Frame_Shift_Del | novel | c.175delN | p.Leu59Ter | p.L59* | P40261 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
NNMT | SNV | Missense_Mutation | rs141072720 | c.52N>T | p.Arg18Trp | p.R18W | P40261 | protein_coding | deleterious(0) | possibly_damaging(0.865) | TCGA-C5-A7CK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
NNMT | SNV | Missense_Mutation | c.616N>C | p.Ile206Leu | p.I206L | P40261 | protein_coding | deleterious(0.01) | benign(0.08) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NNMT | SNV | Missense_Mutation | novel | c.703N>G | p.Phe235Val | p.F235V | P40261 | protein_coding | tolerated(0.27) | benign(0.445) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NNMT | SNV | Missense_Mutation | rs750805211 | c.697N>A | p.Glu233Lys | p.E233K | P40261 | protein_coding | tolerated(0.52) | benign(0.015) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NNMT | SNV | Missense_Mutation | c.141G>T | p.Lys47Asn | p.K47N | P40261 | protein_coding | deleterious(0.02) | benign(0.151) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NNMT | SNV | Missense_Mutation | novel | c.56N>C | p.Asp19Ala | p.D19A | P40261 | protein_coding | tolerated(0.5) | benign(0.006) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NNMT | SNV | Missense_Mutation | novel | c.187N>T | p.Gly63Cys | p.G63C | P40261 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NNMT | SNV | Missense_Mutation | c.133N>A | p.Leu45Ile | p.L45I | P40261 | protein_coding | deleterious(0.04) | benign(0.283) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NNMT | SNV | Missense_Mutation | c.416N>C | p.Leu139Pro | p.L139P | P40261 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4837 | NNMT | DRUGGABLE GENOME | NIACIN | NIACIN | ||
4837 | NNMT | DRUGGABLE GENOME | ARI-3037MO |
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