Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/GOLGA4_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/GOLGA4_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/GOLGA4_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/GOLGA4_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/GOLGA4_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/GOLGA4_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/GOLGA4_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/GOLGA4_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/GOLGA4_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/GOLGA4_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/GOLGA4_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000836113 | Oral cavity | EOLP | regulation of cell size | 35/2218 | 181/18723 | 2.30e-03 | 1.42e-02 | 35 |
GO:005076712 | Oral cavity | EOLP | regulation of neurogenesis | 61/2218 | 364/18723 | 3.20e-03 | 1.86e-02 | 61 |
GO:00486397 | Oral cavity | EOLP | positive regulation of developmental growth | 33/2218 | 174/18723 | 4.12e-03 | 2.27e-02 | 33 |
GO:009887622 | Oral cavity | EOLP | vesicle-mediated transport to the plasma membrane | 27/2218 | 136/18723 | 4.73e-03 | 2.54e-02 | 27 |
GO:009015022 | Oral cavity | EOLP | establishment of protein localization to membrane | 45/2218 | 260/18723 | 5.73e-03 | 2.94e-02 | 45 |
GO:006056015 | Oral cavity | EOLP | developmental growth involved in morphogenesis | 41/2218 | 234/18723 | 6.54e-03 | 3.21e-02 | 41 |
GO:004577313 | Oral cavity | EOLP | positive regulation of axon extension | 11/2218 | 42/18723 | 8.21e-03 | 3.86e-02 | 11 |
GO:000740910 | Oral cavity | EOLP | axonogenesis | 66/2218 | 418/18723 | 8.99e-03 | 4.13e-02 | 66 |
GO:005077212 | Oral cavity | EOLP | positive regulation of axonogenesis | 17/2218 | 79/18723 | 1.01e-02 | 4.55e-02 | 17 |
GO:006156414 | Oral cavity | EOLP | axon development | 72/2218 | 467/18723 | 1.14e-02 | 5.00e-02 | 72 |
GO:001604931 | Oral cavity | NEOLP | cell growth | 90/2005 | 482/18723 | 9.23e-08 | 3.43e-06 | 90 |
GO:003253532 | Oral cavity | NEOLP | regulation of cellular component size | 73/2005 | 383/18723 | 6.70e-07 | 1.93e-05 | 73 |
GO:004819331 | Oral cavity | NEOLP | Golgi vesicle transport | 60/2005 | 296/18723 | 8.09e-07 | 2.21e-05 | 60 |
GO:001072031 | Oral cavity | NEOLP | positive regulation of cell development | 59/2005 | 298/18723 | 2.21e-06 | 5.13e-05 | 59 |
GO:007265931 | Oral cavity | NEOLP | protein localization to plasma membrane | 56/2005 | 284/18723 | 4.51e-06 | 9.60e-05 | 56 |
GO:000689231 | Oral cavity | NEOLP | post-Golgi vesicle-mediated transport | 27/2005 | 104/18723 | 9.30e-06 | 1.79e-04 | 27 |
GO:199077831 | Oral cavity | NEOLP | protein localization to cell periphery | 62/2005 | 333/18723 | 9.84e-06 | 1.86e-04 | 62 |
GO:000155831 | Oral cavity | NEOLP | regulation of cell growth | 73/2005 | 414/18723 | 1.23e-05 | 2.23e-04 | 73 |
GO:001097521 | Oral cavity | NEOLP | regulation of neuron projection development | 77/2005 | 445/18723 | 1.44e-05 | 2.53e-04 | 77 |
GO:004867521 | Oral cavity | NEOLP | axon extension | 29/2005 | 120/18723 | 1.97e-05 | 3.29e-04 | 29 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GOLGA4 | SNV | Missense_Mutation | | c.3932A>G | p.Asn1311Ser | p.N1311S | Q13439 | protein_coding | tolerated(0.75) | benign(0.001) | TCGA-A8-A07L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | | CR |
GOLGA4 | SNV | Missense_Mutation | | c.3722N>A | p.Ile1241Asn | p.I1241N | Q13439 | protein_coding | tolerated(0.55) | benign(0.037) | TCGA-A8-A0A1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
GOLGA4 | SNV | Missense_Mutation | rs768808136 | c.296N>A | p.Arg99Gln | p.R99Q | Q13439 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GOLGA4 | SNV | Missense_Mutation | rs764030527 | c.4237N>A | p.Glu1413Lys | p.E1413K | Q13439 | protein_coding | deleterious(0) | possibly_damaging(0.864) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GOLGA4 | SNV | Missense_Mutation | rs750023676 | c.6565N>A | p.Glu2189Lys | p.E2189K | Q13439 | protein_coding | deleterious(0) | probably_damaging(0.922) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GOLGA4 | SNV | Missense_Mutation | novel | c.431G>A | p.Ser144Asn | p.S144N | Q13439 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AO-A1KP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | SD |
GOLGA4 | SNV | Missense_Mutation | | c.1411N>A | p.Glu471Lys | p.E471K | Q13439 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-BH-A0AW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
GOLGA4 | SNV | Missense_Mutation | | c.6097N>A | p.Glu2033Lys | p.E2033K | Q13439 | protein_coding | deleterious(0) | probably_damaging(0.911) | TCGA-BH-A0HP-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD |
GOLGA4 | SNV | Missense_Mutation | | c.1885N>A | p.Val629Ile | p.V629I | Q13439 | protein_coding | tolerated(0.36) | benign(0) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GOLGA4 | SNV | Missense_Mutation | | c.1372N>A | p.Glu458Lys | p.E458K | Q13439 | protein_coding | deleterious(0.02) | probably_damaging(0.922) | TCGA-BH-A18K-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |