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Gene: FAF1 |
Gene summary for FAF1 |
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Gene information | Species | Human | Gene symbol | FAF1 | Gene ID | 11124 |
Gene name | Fas associated factor 1 | |
Gene Alias | CGI-03 | |
Cytomap | 1p32.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9UNN5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11124 | FAF1 | CCI_1 | Human | Cervix | CC | 9.08e-31 | 2.03e+00 | 0.528 |
11124 | FAF1 | CCI_2 | Human | Cervix | CC | 2.28e-16 | 1.80e+00 | 0.5249 |
11124 | FAF1 | CCI_3 | Human | Cervix | CC | 1.73e-33 | 2.07e+00 | 0.516 |
11124 | FAF1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.35e-22 | -5.96e-01 | 0.0155 |
11124 | FAF1 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.18e-11 | 6.24e-01 | -0.1954 |
11124 | FAF1 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.60e-04 | 3.55e-01 | -0.2602 |
11124 | FAF1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 9.84e-03 | -4.90e-01 | -0.1207 |
11124 | FAF1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.90e-07 | -6.73e-01 | -0.2061 |
11124 | FAF1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 4.50e-03 | -4.75e-01 | -0.1462 |
11124 | FAF1 | HTA11_9341_2000001011 | Human | Colorectum | SER | 2.79e-02 | -3.36e-01 | -0.00410000000000005 |
11124 | FAF1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.01e-05 | -5.15e-01 | -0.0179 |
11124 | FAF1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.14e-18 | -5.55e-01 | 0.096 |
11124 | FAF1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 7.06e-03 | -6.34e-01 | 0.0451 |
11124 | FAF1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.76e-08 | -4.00e-01 | 0.294 |
11124 | FAF1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 6.38e-05 | 6.66e-01 | 0.3487 |
11124 | FAF1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.52e-04 | -6.45e-01 | 0.2585 |
11124 | FAF1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.94e-13 | -5.29e-01 | 0.3005 |
11124 | FAF1 | F007 | Human | Colorectum | FAP | 3.06e-02 | -2.96e-01 | 0.1176 |
11124 | FAF1 | A001-C-207 | Human | Colorectum | FAP | 4.00e-06 | -3.96e-01 | 0.1278 |
11124 | FAF1 | A015-C-203 | Human | Colorectum | FAP | 2.95e-37 | -6.66e-01 | -0.1294 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004277519 | Oral cavity | LP | mitochondrial ATP synthesis coupled electron transport | 69/4623 | 95/18723 | 9.69e-23 | 3.04e-20 | 69 |
GO:004533319 | Oral cavity | LP | cellular respiration | 124/4623 | 230/18723 | 1.35e-21 | 3.38e-19 | 124 |
GO:000609119 | Oral cavity | LP | generation of precursor metabolites and energy | 214/4623 | 490/18723 | 1.12e-20 | 2.60e-18 | 214 |
GO:002290419 | Oral cavity | LP | respiratory electron transport chain | 75/4623 | 114/18723 | 1.92e-20 | 4.14e-18 | 75 |
GO:001964619 | Oral cavity | LP | aerobic electron transport chain | 62/4623 | 87/18723 | 7.13e-20 | 1.49e-17 | 62 |
GO:003310819 | Oral cavity | LP | mitochondrial respiratory chain complex assembly | 63/4623 | 93/18723 | 2.24e-18 | 4.13e-16 | 63 |
GO:0006119110 | Oral cavity | LP | oxidative phosphorylation | 81/4623 | 141/18723 | 9.70e-17 | 1.48e-14 | 81 |
GO:001598019 | Oral cavity | LP | energy derivation by oxidation of organic compounds | 145/4623 | 318/18723 | 2.44e-16 | 3.64e-14 | 145 |
GO:0046034110 | Oral cavity | LP | ATP metabolic process | 128/4623 | 277/18723 | 3.95e-15 | 5.38e-13 | 128 |
GO:000612019 | Oral cavity | LP | mitochondrial electron transport, NADH to ubiquinone | 39/4623 | 51/18723 | 1.08e-14 | 1.33e-12 | 39 |
GO:001025719 | Oral cavity | LP | NADH dehydrogenase complex assembly | 41/4623 | 57/18723 | 7.93e-14 | 7.89e-12 | 41 |
GO:003298119 | Oral cavity | LP | mitochondrial respiratory chain complex I assembly | 41/4623 | 57/18723 | 7.93e-14 | 7.89e-12 | 41 |
GO:005113117 | Oral cavity | LP | chaperone-mediated protein complex assembly | 17/4623 | 23/18723 | 9.55e-07 | 2.43e-05 | 17 |
GO:200123326 | Oral cavity | EOLP | regulation of apoptotic signaling pathway | 99/2218 | 356/18723 | 1.25e-16 | 1.25e-13 | 99 |
GO:004325426 | Oral cavity | EOLP | regulation of protein-containing complex assembly | 112/2218 | 428/18723 | 1.58e-16 | 1.35e-13 | 112 |
GO:000989625 | Oral cavity | EOLP | positive regulation of catabolic process | 118/2218 | 492/18723 | 2.32e-14 | 9.26e-12 | 118 |
GO:003133125 | Oral cavity | EOLP | positive regulation of cellular catabolic process | 106/2218 | 427/18723 | 4.63e-14 | 1.63e-11 | 106 |
GO:003133424 | Oral cavity | EOLP | positive regulation of protein-containing complex assembly | 67/2218 | 237/18723 | 4.77e-12 | 8.17e-10 | 67 |
GO:001049825 | Oral cavity | EOLP | proteasomal protein catabolic process | 108/2218 | 490/18723 | 7.79e-11 | 9.51e-09 | 108 |
GO:004217626 | Oral cavity | EOLP | regulation of protein catabolic process | 90/2218 | 391/18723 | 2.92e-10 | 2.58e-08 | 90 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAF1 | SNV | Missense_Mutation | c.1948G>C | p.Glu650Gln | p.E650Q | Q9UNN5 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.954) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
FAF1 | SNV | Missense_Mutation | novel | c.164A>C | p.Glu55Ala | p.E55A | Q9UNN5 | protein_coding | tolerated(0.11) | benign(0.007) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAF1 | SNV | Missense_Mutation | c.1639N>C | p.Glu547Gln | p.E547Q | Q9UNN5 | protein_coding | tolerated(0.14) | probably_damaging(0.996) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAF1 | SNV | Missense_Mutation | c.604N>A | p.Glu202Lys | p.E202K | Q9UNN5 | protein_coding | tolerated(0.77) | benign(0.164) | TCGA-EX-A1H6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
FAF1 | SNV | Missense_Mutation | novel | c.1479A>T | p.Glu493Asp | p.E493D | Q9UNN5 | protein_coding | tolerated(0.57) | benign(0.072) | TCGA-MA-AA3Y-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
FAF1 | insertion | Frame_Shift_Ins | novel | c.1597_1598insGA | p.Met533ArgfsTer26 | p.M533Rfs*26 | Q9UNN5 | protein_coding | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
FAF1 | SNV | Missense_Mutation | novel | c.1647A>C | p.Glu549Asp | p.E549D | Q9UNN5 | protein_coding | tolerated(0.11) | possibly_damaging(0.679) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FAF1 | SNV | Missense_Mutation | c.1498N>A | p.Glu500Lys | p.E500K | Q9UNN5 | protein_coding | deleterious(0) | possibly_damaging(0.679) | TCGA-AD-6963-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FAF1 | SNV | Missense_Mutation | c.1805T>G | p.Phe602Cys | p.F602C | Q9UNN5 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FAF1 | SNV | Missense_Mutation | novel | c.571N>C | p.Asn191His | p.N191H | Q9UNN5 | protein_coding | tolerated(0.2) | possibly_damaging(0.453) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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