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Gene: CHMP2B |
Gene summary for CHMP2B |
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Gene information | Species | Human | Gene symbol | CHMP2B | Gene ID | 25978 |
Gene name | charged multivesicular body protein 2B | |
Gene Alias | ALS17 | |
Cytomap | 3p11.2 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | B2RE76 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25978 | CHMP2B | LZE4T | Human | Esophagus | ESCC | 4.43e-11 | 2.26e-01 | 0.0811 |
25978 | CHMP2B | LZE5T | Human | Esophagus | ESCC | 4.45e-04 | 3.61e-01 | 0.0514 |
25978 | CHMP2B | LZE7T | Human | Esophagus | ESCC | 3.01e-06 | 6.51e-02 | 0.0667 |
25978 | CHMP2B | LZE8T | Human | Esophagus | ESCC | 5.57e-06 | 5.19e-01 | 0.067 |
25978 | CHMP2B | LZE20T | Human | Esophagus | ESCC | 3.32e-03 | 2.22e-01 | 0.0662 |
25978 | CHMP2B | LZE24T | Human | Esophagus | ESCC | 7.25e-16 | 7.64e-01 | 0.0596 |
25978 | CHMP2B | LZE6T | Human | Esophagus | ESCC | 1.25e-06 | 9.44e-02 | 0.0845 |
25978 | CHMP2B | P2T-E | Human | Esophagus | ESCC | 1.13e-22 | 2.80e-01 | 0.1177 |
25978 | CHMP2B | P4T-E | Human | Esophagus | ESCC | 5.67e-24 | 6.00e-01 | 0.1323 |
25978 | CHMP2B | P5T-E | Human | Esophagus | ESCC | 1.33e-09 | 1.78e-01 | 0.1327 |
25978 | CHMP2B | P8T-E | Human | Esophagus | ESCC | 4.98e-16 | 3.59e-01 | 0.0889 |
25978 | CHMP2B | P9T-E | Human | Esophagus | ESCC | 1.19e-15 | 1.86e-01 | 0.1131 |
25978 | CHMP2B | P10T-E | Human | Esophagus | ESCC | 1.70e-13 | 2.15e-01 | 0.116 |
25978 | CHMP2B | P11T-E | Human | Esophagus | ESCC | 2.97e-12 | 9.60e-01 | 0.1426 |
25978 | CHMP2B | P12T-E | Human | Esophagus | ESCC | 1.12e-18 | 3.79e-01 | 0.1122 |
25978 | CHMP2B | P15T-E | Human | Esophagus | ESCC | 3.70e-17 | 3.82e-01 | 0.1149 |
25978 | CHMP2B | P16T-E | Human | Esophagus | ESCC | 1.43e-17 | 2.38e-01 | 0.1153 |
25978 | CHMP2B | P17T-E | Human | Esophagus | ESCC | 5.56e-03 | 2.25e-01 | 0.1278 |
25978 | CHMP2B | P19T-E | Human | Esophagus | ESCC | 4.43e-06 | 8.70e-01 | 0.1662 |
25978 | CHMP2B | P20T-E | Human | Esophagus | ESCC | 3.37e-21 | 5.47e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19016735 | Prostate | BPH | regulation of mitotic spindle assembly | 10/3107 | 18/18723 | 1.87e-04 | 1.55e-03 | 10 |
GO:00991752 | Prostate | BPH | regulation of postsynapse organization | 29/3107 | 90/18723 | 1.96e-04 | 1.61e-03 | 29 |
GO:00616404 | Prostate | BPH | cytoskeleton-dependent cytokinesis | 31/3107 | 100/18723 | 2.63e-04 | 2.06e-03 | 31 |
GO:00069972 | Prostate | BPH | nucleus organization | 38/3107 | 133/18723 | 3.69e-04 | 2.72e-03 | 38 |
GO:00903075 | Prostate | BPH | mitotic spindle assembly | 22/3107 | 65/18723 | 5.23e-04 | 3.68e-03 | 22 |
GO:00070326 | Prostate | BPH | endosome organization | 26/3107 | 82/18723 | 5.42e-04 | 3.81e-03 | 26 |
GO:00070516 | Prostate | BPH | spindle organization | 48/3107 | 184/18723 | 6.91e-04 | 4.60e-03 | 48 |
GO:00002814 | Prostate | BPH | mitotic cytokinesis | 23/3107 | 71/18723 | 7.95e-04 | 5.21e-03 | 23 |
GO:00190685 | Prostate | BPH | virion assembly | 14/3107 | 35/18723 | 8.33e-04 | 5.41e-03 | 14 |
GO:19021154 | Prostate | BPH | regulation of organelle assembly | 48/3107 | 186/18723 | 8.91e-04 | 5.72e-03 | 48 |
GO:00325064 | Prostate | BPH | cytokinetic process | 15/3107 | 39/18723 | 8.91e-04 | 5.72e-03 | 15 |
GO:19039028 | Prostate | BPH | positive regulation of viral life cycle | 12/3107 | 29/18723 | 1.37e-03 | 8.19e-03 | 12 |
GO:00070417 | Prostate | BPH | lysosomal transport | 32/3107 | 114/18723 | 1.42e-03 | 8.47e-03 | 32 |
GO:00719854 | Prostate | BPH | multivesicular body sorting pathway | 14/3107 | 37/18723 | 1.58e-03 | 9.23e-03 | 14 |
GO:00108242 | Prostate | BPH | regulation of centrosome duplication | 16/3107 | 45/18723 | 1.62e-03 | 9.39e-03 | 16 |
GO:0050890 | Prostate | BPH | cognition | 69/3107 | 296/18723 | 1.68e-03 | 9.69e-03 | 69 |
GO:01400144 | Prostate | BPH | mitotic nuclear division | 67/3107 | 287/18723 | 1.87e-03 | 1.07e-02 | 67 |
GO:00990104 | Prostate | BPH | modification of postsynaptic structure | 8/3107 | 16/18723 | 2.08e-03 | 1.16e-02 | 8 |
GO:19024106 | Prostate | BPH | mitotic cytokinetic process | 10/3107 | 23/18723 | 2.20e-03 | 1.22e-02 | 10 |
GO:004390317 | Prostate | BPH | regulation of biological process involved in symbiotic interaction | 22/3107 | 72/18723 | 2.38e-03 | 1.29e-02 | 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05014210 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa05022210 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa0501438 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0502238 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa0501414 | Liver | Cirrhotic | Amyotrophic lateral sclerosis | 187/2530 | 364/8465 | 1.56e-18 | 6.50e-17 | 4.01e-17 | 187 |
hsa0502214 | Liver | Cirrhotic | Pathways of neurodegeneration - multiple diseases | 217/2530 | 476/8465 | 7.30e-14 | 2.03e-12 | 1.25e-12 | 217 |
hsa0414412 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0501415 | Liver | Cirrhotic | Amyotrophic lateral sclerosis | 187/2530 | 364/8465 | 1.56e-18 | 6.50e-17 | 4.01e-17 | 187 |
hsa0502215 | Liver | Cirrhotic | Pathways of neurodegeneration - multiple diseases | 217/2530 | 476/8465 | 7.30e-14 | 2.03e-12 | 1.25e-12 | 217 |
hsa0414413 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0501422 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0502222 | Liver | HCC | Pathways of neurodegeneration - multiple diseases | 298/4020 | 476/8465 | 6.59e-12 | 1.30e-10 | 7.22e-11 | 298 |
hsa0501432 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa0414432 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0502232 | Liver | HCC | Pathways of neurodegeneration - multiple diseases | 298/4020 | 476/8465 | 6.59e-12 | 1.30e-10 | 7.22e-11 | 298 |
hsa0501428 | Oral cavity | OSCC | Amyotrophic lateral sclerosis | 246/3704 | 364/8465 | 6.65e-21 | 1.11e-18 | 5.67e-19 | 246 |
hsa0414427 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHMP2B | SNV | Missense_Mutation | c.369N>C | p.Gln123His | p.Q123H | Q9UQN3 | protein_coding | deleterious(0.03) | possibly_damaging(0.77) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CHMP2B | SNV | Missense_Mutation | c.296N>T | p.Ala99Val | p.A99V | Q9UQN3 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CHMP2B | SNV | Missense_Mutation | c.194T>G | p.Leu65Arg | p.L65R | Q9UQN3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CHMP2B | SNV | Missense_Mutation | novel | c.499N>A | p.Leu167Ile | p.L167I | Q9UQN3 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CHMP2B | SNV | Missense_Mutation | novel | c.554N>T | p.Ala185Val | p.A185V | Q9UQN3 | protein_coding | tolerated(0.28) | benign(0.028) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CHMP2B | SNV | Missense_Mutation | novel | c.327N>A | p.Met109Ile | p.M109I | Q9UQN3 | protein_coding | deleterious(0.01) | possibly_damaging(0.785) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CHMP2B | SNV | Missense_Mutation | novel | c.25A>T | p.Thr9Ser | p.T9S | Q9UQN3 | protein_coding | tolerated(0.19) | benign(0) | TCGA-AX-A2HJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CHMP2B | SNV | Missense_Mutation | novel | c.238N>G | p.Ser80Ala | p.S80A | Q9UQN3 | protein_coding | tolerated(0.34) | benign(0.23) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CHMP2B | SNV | Missense_Mutation | novel | c.375N>A | p.Met125Ile | p.M125I | Q9UQN3 | protein_coding | deleterious(0.04) | benign(0.162) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
CHMP2B | SNV | Missense_Mutation | novel | c.499C>A | p.Leu167Ile | p.L167I | Q9UQN3 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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