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Gene: C1QB |
Gene summary for C1QB |
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Gene information | Species | Human | Gene symbol | C1QB | Gene ID | 713 |
Gene name | complement C1q B chain | |
Gene Alias | C1QB | |
Cytomap | 1p36.12 | |
Gene Type | protein-coding | GO ID | GO:0002250 | UniProtAcc | A0A024RAB9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
713 | C1QB | NCCBC11 | Human | Breast | DCIS | 8.68e-09 | 8.69e-01 | 0.1232 |
713 | C1QB | NCCBC14 | Human | Breast | DCIS | 5.13e-06 | 4.39e-01 | 0.2021 |
713 | C1QB | NCCBC3 | Human | Breast | DCIS | 1.95e-73 | 1.32e+00 | 0.1198 |
713 | C1QB | NCCBC5 | Human | Breast | DCIS | 3.14e-14 | 7.11e-01 | 0.2046 |
713 | C1QB | P2 | Human | Breast | IDC | 7.99e-03 | 2.92e-01 | 0.21 |
713 | C1QB | P16T-E | Human | Esophagus | ESCC | 1.64e-124 | 2.62e+00 | 0.1153 |
713 | C1QB | P20T-E | Human | Esophagus | ESCC | 2.85e-94 | 2.25e+00 | 0.1124 |
713 | C1QB | P21T-E | Human | Esophagus | ESCC | 1.81e-130 | 3.33e+00 | 0.1617 |
713 | C1QB | P23T-E | Human | Esophagus | ESCC | 2.93e-93 | 2.67e+00 | 0.108 |
713 | C1QB | P36T-E | Human | Esophagus | ESCC | 1.35e-02 | 9.16e-02 | 0.1187 |
713 | C1QB | P39T-E | Human | Esophagus | ESCC | 5.69e-86 | 1.80e+00 | 0.0894 |
713 | C1QB | P42T-E | Human | Esophagus | ESCC | 3.82e-71 | 2.17e+00 | 0.1175 |
713 | C1QB | P48T-E | Human | Esophagus | ESCC | 2.55e-72 | 1.53e+00 | 0.0959 |
713 | C1QB | P49T-E | Human | Esophagus | ESCC | 5.54e-31 | 3.69e+00 | 0.1768 |
713 | C1QB | P52T-E | Human | Esophagus | ESCC | 4.71e-95 | 2.63e+00 | 0.1555 |
713 | C1QB | P54T-E | Human | Esophagus | ESCC | 2.00e-86 | 2.37e+00 | 0.0975 |
713 | C1QB | P56T-E | Human | Esophagus | ESCC | 2.56e-21 | 2.95e+00 | 0.1613 |
713 | C1QB | P89T-E | Human | Esophagus | ESCC | 2.99e-37 | 3.57e+00 | 0.1752 |
713 | C1QB | P104T-E | Human | Esophagus | ESCC | 1.37e-07 | 1.46e+00 | 0.0931 |
713 | C1QB | P107T-E | Human | Esophagus | ESCC | 5.28e-119 | 3.94e+00 | 0.171 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:009858611 | Endometrium | EEC | cellular response to virus | 20/2168 | 84/18723 | 1.21e-03 | 1.02e-02 | 20 |
GO:000222112 | Endometrium | EEC | pattern recognition receptor signaling pathway | 34/2168 | 172/18723 | 1.22e-03 | 1.02e-02 | 34 |
GO:000268813 | Endometrium | EEC | regulation of leukocyte chemotaxis | 26/2168 | 122/18723 | 1.45e-03 | 1.18e-02 | 26 |
GO:000268713 | Endometrium | EEC | positive regulation of leukocyte migration | 28/2168 | 135/18723 | 1.50e-03 | 1.21e-02 | 28 |
GO:006220712 | Endometrium | EEC | regulation of pattern recognition receptor signaling pathway | 23/2168 | 105/18723 | 1.81e-03 | 1.41e-02 | 23 |
GO:000756613 | Endometrium | EEC | embryo implantation | 14/2168 | 53/18723 | 2.26e-03 | 1.68e-02 | 14 |
GO:007167513 | Endometrium | EEC | regulation of mononuclear cell migration | 24/2168 | 115/18723 | 2.89e-03 | 2.04e-02 | 24 |
GO:005092112 | Endometrium | EEC | positive regulation of chemotaxis | 28/2168 | 141/18723 | 2.94e-03 | 2.07e-02 | 28 |
GO:004349113 | Endometrium | EEC | protein kinase B signaling | 38/2168 | 211/18723 | 3.74e-03 | 2.49e-02 | 38 |
GO:005189612 | Endometrium | EEC | regulation of protein kinase B signaling | 34/2168 | 185/18723 | 4.24e-03 | 2.75e-02 | 34 |
GO:00026907 | Endometrium | EEC | positive regulation of leukocyte chemotaxis | 20/2168 | 94/18723 | 4.94e-03 | 3.11e-02 | 20 |
GO:00716746 | Endometrium | EEC | mononuclear cell migration | 35/2168 | 196/18723 | 6.00e-03 | 3.57e-02 | 35 |
GO:00716776 | Endometrium | EEC | positive regulation of mononuclear cell migration | 15/2168 | 65/18723 | 6.44e-03 | 3.77e-02 | 15 |
GO:00305939 | Endometrium | EEC | neutrophil chemotaxis | 21/2168 | 103/18723 | 6.75e-03 | 3.93e-02 | 21 |
GO:00304493 | Endometrium | EEC | regulation of complement activation | 7/2168 | 21/18723 | 7.38e-03 | 4.15e-02 | 7 |
GO:00716219 | Endometrium | EEC | granulocyte chemotaxis | 24/2168 | 125/18723 | 8.60e-03 | 4.70e-02 | 24 |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0517124 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0517134 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0502043 | Breast | DCIS | Prion disease | 100/846 | 273/8465 | 1.44e-33 | 1.55e-31 | 1.14e-31 | 100 |
hsa0517144 | Breast | DCIS | Coronavirus disease - COVID-19 | 86/846 | 232/8465 | 2.42e-29 | 1.56e-27 | 1.15e-27 | 86 |
hsa05150 | Breast | DCIS | Staphylococcus aureus infection | 19/846 | 96/8465 | 2.68e-03 | 1.67e-02 | 1.23e-02 | 19 |
hsa051336 | Breast | DCIS | Pertussis | 15/846 | 76/8465 | 7.42e-03 | 3.48e-02 | 2.56e-02 | 15 |
hsa0502053 | Breast | DCIS | Prion disease | 100/846 | 273/8465 | 1.44e-33 | 1.55e-31 | 1.14e-31 | 100 |
hsa0517154 | Breast | DCIS | Coronavirus disease - COVID-19 | 86/846 | 232/8465 | 2.42e-29 | 1.56e-27 | 1.15e-27 | 86 |
hsa051501 | Breast | DCIS | Staphylococcus aureus infection | 19/846 | 96/8465 | 2.68e-03 | 1.67e-02 | 1.23e-02 | 19 |
hsa0513311 | Breast | DCIS | Pertussis | 15/846 | 76/8465 | 7.42e-03 | 3.48e-02 | 2.56e-02 | 15 |
hsa05171211 | Esophagus | ESCC | Coronavirus disease - COVID-19 | 156/4205 | 232/8465 | 3.18e-08 | 2.68e-07 | 1.37e-07 | 156 |
hsa05171310 | Esophagus | ESCC | Coronavirus disease - COVID-19 | 156/4205 | 232/8465 | 3.18e-08 | 2.68e-07 | 1.37e-07 | 156 |
hsa0517122 | Liver | Cirrhotic | Coronavirus disease - COVID-19 | 136/2530 | 232/8465 | 3.28e-20 | 1.82e-18 | 1.12e-18 | 136 |
hsa0502014 | Liver | Cirrhotic | Prion disease | 152/2530 | 273/8465 | 1.84e-19 | 8.78e-18 | 5.41e-18 | 152 |
hsa046102 | Liver | Cirrhotic | Complement and coagulation cascades | 48/2530 | 86/8465 | 4.41e-07 | 5.44e-06 | 3.35e-06 | 48 |
hsa05133 | Liver | Cirrhotic | Pertussis | 37/2530 | 76/8465 | 4.17e-04 | 2.57e-03 | 1.58e-03 | 37 |
hsa04936 | Liver | Cirrhotic | Alcoholic liver disease | 60/2530 | 142/8465 | 1.07e-03 | 5.85e-03 | 3.61e-03 | 60 |
hsa0517132 | Liver | Cirrhotic | Coronavirus disease - COVID-19 | 136/2530 | 232/8465 | 3.28e-20 | 1.82e-18 | 1.12e-18 | 136 |
hsa0502015 | Liver | Cirrhotic | Prion disease | 152/2530 | 273/8465 | 1.84e-19 | 8.78e-18 | 5.41e-18 | 152 |
hsa046103 | Liver | Cirrhotic | Complement and coagulation cascades | 48/2530 | 86/8465 | 4.41e-07 | 5.44e-06 | 3.35e-06 | 48 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C1QB | SNV | Missense_Mutation | c.286N>A | p.Gly96Ser | p.G96S | P02746 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A2-A0YD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
C1QB | SNV | Missense_Mutation | c.634N>G | p.Met212Val | p.M212V | P02746 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C1QB | insertion | Frame_Shift_Ins | novel | c.495dupC | p.Gly166ArgfsTer34 | p.G166Rfs*34 | P02746 | protein_coding | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
C1QB | SNV | Missense_Mutation | novel | c.131C>T | p.Pro44Leu | p.P44L | P02746 | protein_coding | deleterious(0.02) | probably_damaging(0.99) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
C1QB | SNV | Missense_Mutation | novel | c.360N>T | p.Gln120His | p.Q120H | P02746 | protein_coding | tolerated(1) | benign(0.05) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C1QB | SNV | Missense_Mutation | novel | c.602C>T | p.Ala201Val | p.A201V | P02746 | protein_coding | tolerated(1) | benign(0.001) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C1QB | SNV | Missense_Mutation | c.701G>A | p.Gly234Asp | p.G234D | P02746 | protein_coding | deleterious(0) | possibly_damaging(0.889) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C1QB | SNV | Missense_Mutation | novel | c.151N>A | p.Gly51Ser | p.G51S | P02746 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A0IZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C1QB | SNV | Missense_Mutation | rs745414763 | c.338N>T | p.Ser113Leu | p.S113L | P02746 | protein_coding | deleterious(0.05) | possibly_damaging(0.703) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C1QB | SNV | Missense_Mutation | rs770317321 | c.148G>A | p.Asp50Asn | p.D50N | P02746 | protein_coding | tolerated(0.25) | benign(0.033) | TCGA-BS-A0U8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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