![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: AIF1 |
Gene summary for AIF1 |
![]() |
Gene information | Species | Human | Gene symbol | AIF1 | Gene ID | 199 |
Gene name | allograft inflammatory factor 1 | |
Gene Alias | AIF-1 | |
Cytomap | 6p21.33 | |
Gene Type | protein-coding | GO ID | GO:0000082 | UniProtAcc | I3WTX1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
199 | AIF1 | NCCBC11 | Human | Breast | DCIS | 9.00e-08 | 7.92e-01 | 0.1232 |
199 | AIF1 | NCCBC14 | Human | Breast | DCIS | 2.44e-08 | 5.08e-01 | 0.2021 |
199 | AIF1 | NCCBC3 | Human | Breast | DCIS | 1.22e-39 | 1.05e+00 | 0.1198 |
199 | AIF1 | NCCBC5 | Human | Breast | DCIS | 6.97e-21 | 8.38e-01 | 0.2046 |
199 | AIF1 | N_HPV_1 | Human | Cervix | N_HPV | 4.36e-05 | 5.04e-01 | 0.0079 |
199 | AIF1 | N_HPV_2 | Human | Cervix | N_HPV | 5.56e-05 | 3.83e-01 | -0.0131 |
199 | AIF1 | CCI_1 | Human | Cervix | CC | 3.17e-04 | -6.97e-01 | 0.528 |
199 | AIF1 | CCI_2 | Human | Cervix | CC | 4.44e-02 | -6.75e-01 | 0.5249 |
199 | AIF1 | CCI_3 | Human | Cervix | CC | 2.19e-04 | -6.81e-01 | 0.516 |
199 | AIF1 | CCII_1 | Human | Cervix | CC | 3.08e-09 | -6.97e-01 | 0.3249 |
199 | AIF1 | Tumor | Human | Cervix | CC | 3.04e-18 | -6.91e-01 | 0.1241 |
199 | AIF1 | sample1 | Human | Cervix | CC | 6.37e-04 | -6.42e-01 | 0.0959 |
199 | AIF1 | sample3 | Human | Cervix | CC | 1.02e-18 | -6.89e-01 | 0.1387 |
199 | AIF1 | H2 | Human | Cervix | HSIL_HPV | 2.16e-10 | -6.25e-01 | 0.0632 |
199 | AIF1 | T1 | Human | Cervix | CC | 3.61e-09 | -6.13e-01 | 0.0918 |
199 | AIF1 | T3 | Human | Cervix | CC | 3.70e-17 | -6.88e-01 | 0.1389 |
199 | AIF1 | S43 | Human | Liver | Cirrhotic | 1.08e-07 | -3.58e-01 | -0.0187 |
199 | AIF1 | HCC1_Meng | Human | Liver | HCC | 6.75e-16 | -1.84e-01 | 0.0246 |
199 | AIF1 | HCC2_Meng | Human | Liver | HCC | 2.01e-06 | -3.50e-01 | 0.0107 |
199 | AIF1 | cirrhotic1 | Human | Liver | Cirrhotic | 9.65e-05 | -2.13e-01 | 0.0202 |
Page: 1 2 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000726521 | Liver | HCC | Ras protein signal transduction | 187/7958 | 337/18723 | 8.89e-07 | 1.35e-05 | 187 |
GO:000863712 | Liver | HCC | apoptotic mitochondrial changes | 70/7958 | 107/18723 | 1.39e-06 | 2.01e-05 | 70 |
GO:005101722 | Liver | HCC | actin filament bundle assembly | 96/7958 | 157/18723 | 1.81e-06 | 2.52e-05 | 96 |
GO:19019901 | Liver | HCC | regulation of mitotic cell cycle phase transition | 167/7958 | 299/18723 | 1.96e-06 | 2.71e-05 | 167 |
GO:19019871 | Liver | HCC | regulation of cell cycle phase transition | 211/7958 | 390/18723 | 2.11e-06 | 2.89e-05 | 211 |
GO:006157222 | Liver | HCC | actin filament bundle organization | 97/7958 | 161/18723 | 4.04e-06 | 5.22e-05 | 97 |
GO:005138421 | Liver | HCC | response to glucocorticoid | 90/7958 | 148/18723 | 5.18e-06 | 6.47e-05 | 90 |
GO:004578711 | Liver | HCC | positive regulation of cell cycle | 172/7958 | 313/18723 | 5.29e-06 | 6.58e-05 | 172 |
GO:003196021 | Liver | HCC | response to corticosteroid | 98/7958 | 167/18723 | 1.73e-05 | 1.87e-04 | 98 |
GO:00448432 | Liver | HCC | cell cycle G1/S phase transition | 134/7958 | 241/18723 | 2.60e-05 | 2.70e-04 | 134 |
GO:00000822 | Liver | HCC | G1/S transition of mitotic cell cycle | 119/7958 | 214/18723 | 7.11e-05 | 6.39e-04 | 119 |
GO:00343411 | Liver | HCC | response to interferon-gamma | 82/7958 | 141/18723 | 1.25e-04 | 1.03e-03 | 82 |
GO:00713461 | Liver | HCC | cellular response to interferon-gamma | 70/7958 | 118/18723 | 1.66e-04 | 1.32e-03 | 70 |
GO:200105722 | Liver | HCC | reactive nitrogen species metabolic process | 51/7958 | 82/18723 | 2.50e-04 | 1.86e-03 | 51 |
GO:004620922 | Liver | HCC | nitric oxide metabolic process | 50/7958 | 81/18723 | 3.72e-04 | 2.56e-03 | 50 |
GO:008016422 | Liver | HCC | regulation of nitric oxide metabolic process | 41/7958 | 64/18723 | 4.06e-04 | 2.74e-03 | 41 |
GO:00900683 | Liver | HCC | positive regulation of cell cycle process | 125/7958 | 236/18723 | 7.21e-04 | 4.40e-03 | 125 |
GO:004593111 | Liver | HCC | positive regulation of mitotic cell cycle | 69/7958 | 121/18723 | 8.79e-04 | 5.20e-03 | 69 |
GO:004542822 | Liver | HCC | regulation of nitric oxide biosynthetic process | 39/7958 | 62/18723 | 9.46e-04 | 5.50e-03 | 39 |
GO:000680922 | Liver | HCC | nitric oxide biosynthetic process | 46/7958 | 76/18723 | 1.15e-03 | 6.53e-03 | 46 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AIF1 | SNV | Missense_Mutation | novel | c.253N>C | p.Glu85Gln | p.E85Q | P55008 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-C5-A2M1-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
AIF1 | deletion | Frame_Shift_Del | c.413delC | p.Pro138GlnfsTer36 | p.P138Qfs*36 | P55008 | protein_coding | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
AIF1 | SNV | Missense_Mutation | novel | c.4N>T | p.Ser2Cys | p.S2C | P55008 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.757) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
AIF1 | SNV | Missense_Mutation | novel | c.215N>T | p.Arg72Leu | p.R72L | P55008 | protein_coding | tolerated(0.15) | possibly_damaging(0.887) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AIF1 | SNV | Missense_Mutation | novel | c.261G>T | p.Lys87Asn | p.K87N | P55008 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AIF1 | SNV | Missense_Mutation | novel | c.53N>T | p.Ala18Val | p.A18V | P55008 | protein_coding | tolerated(0.1) | benign(0.033) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
AIF1 | SNV | Missense_Mutation | c.220N>A | p.Leu74Met | p.L74M | P55008 | protein_coding | tolerated(1) | benign(0.17) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
AIF1 | SNV | Missense_Mutation | novel | c.412C>A | p.Pro138Thr | p.P138T | P55008 | protein_coding | deleterious(0) | probably_damaging(0.916) | TCGA-78-8662-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
AIF1 | SNV | Missense_Mutation | c.406N>T | p.Gly136Cys | p.G136C | P55008 | protein_coding | deleterious(0.02) | benign(0.029) | TCGA-BR-4280-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
AIF1 | SNV | Missense_Mutation | c.440N>T | p.Pro147Leu | p.P147L | P55008 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |