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Gene: ZYX |
Gene summary for ZYX |
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Gene information | Species | Human | Gene symbol | ZYX | Gene ID | 7791 |
Gene name | zyxin | |
Gene Alias | ESP-2 | |
Cytomap | 7q34 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q15942 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7791 | ZYX | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.25e-08 | 2.39e-01 | 0.0155 |
7791 | ZYX | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.77e-05 | 3.30e-01 | -0.1808 |
7791 | ZYX | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.94e-13 | 5.75e-01 | -0.0811 |
7791 | ZYX | HTA11_78_2000001011 | Human | Colorectum | AD | 8.01e-14 | 4.37e-01 | -0.1088 |
7791 | ZYX | HTA11_347_2000001011 | Human | Colorectum | AD | 5.83e-04 | 1.82e-01 | -0.1954 |
7791 | ZYX | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.57e-04 | 2.91e-01 | -0.1207 |
7791 | ZYX | HTA11_696_2000001011 | Human | Colorectum | AD | 1.16e-02 | 2.16e-01 | -0.1464 |
7791 | ZYX | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.61e-05 | 4.03e-01 | -0.059 |
7791 | ZYX | HTA11_546_2000001011 | Human | Colorectum | AD | 1.05e-03 | 3.39e-01 | -0.0842 |
7791 | ZYX | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.01e-03 | 5.08e-01 | 0.0451 |
7791 | ZYX | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.67e-02 | 2.51e-01 | -0.0177 |
7791 | ZYX | HTA11_6801_2000001011 | Human | Colorectum | SER | 2.37e-03 | 3.66e-01 | 0.0171 |
7791 | ZYX | HTA11_10711_2000001011 | Human | Colorectum | AD | 9.93e-07 | 4.12e-01 | 0.0338 |
7791 | ZYX | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.00e-20 | 4.95e-01 | 0.0674 |
7791 | ZYX | HTA11_6818_2000001011 | Human | Colorectum | AD | 9.79e-04 | 3.45e-01 | 0.0112 |
7791 | ZYX | HTA11_99999965104_69814 | Human | Colorectum | MSS | 9.12e-23 | 6.86e-01 | 0.281 |
7791 | ZYX | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.14e-13 | 4.30e-01 | 0.3859 |
7791 | ZYX | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.49e-12 | 6.82e-01 | 0.2585 |
7791 | ZYX | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.13e-08 | 2.80e-01 | 0.3005 |
7791 | ZYX | LZE3D | Human | Esophagus | HGIN | 4.39e-03 | 5.11e-01 | 0.0668 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00070152 | Colorectum | MSS | actin filament organization | 146/3467 | 442/18723 | 1.16e-13 | 2.67e-11 | 146 |
GO:00315892 | Colorectum | MSS | cell-substrate adhesion | 104/3467 | 363/18723 | 1.35e-06 | 4.51e-05 | 104 |
GO:00615722 | Colorectum | MSS | actin filament bundle organization | 50/3467 | 161/18723 | 8.18e-05 | 1.35e-03 | 50 |
GO:00510172 | Colorectum | MSS | actin filament bundle assembly | 49/3467 | 157/18723 | 8.35e-05 | 1.36e-03 | 49 |
GO:00071602 | Colorectum | MSS | cell-matrix adhesion | 65/3467 | 233/18723 | 2.77e-04 | 3.67e-03 | 65 |
GO:00310322 | Colorectum | MSS | actomyosin structure organization | 53/3467 | 196/18723 | 2.04e-03 | 1.75e-02 | 53 |
GO:00300382 | Colorectum | MSS | contractile actin filament bundle assembly | 32/3467 | 106/18723 | 2.41e-03 | 1.96e-02 | 32 |
GO:00431492 | Colorectum | MSS | stress fiber assembly | 32/3467 | 106/18723 | 2.41e-03 | 1.96e-02 | 32 |
GO:00071781 | Colorectum | MSS | transmembrane receptor protein serine/threonine kinase signaling pathway | 86/3467 | 355/18723 | 4.04e-03 | 2.95e-02 | 86 |
GO:003158919 | Esophagus | ESCC | cell-substrate adhesion | 221/8552 | 363/18723 | 3.06e-09 | 6.62e-08 | 221 |
GO:000701527 | Esophagus | ESCC | actin filament organization | 259/8552 | 442/18723 | 2.37e-08 | 4.50e-07 | 259 |
GO:00715599 | Esophagus | ESCC | response to transforming growth factor beta | 157/8552 | 256/18723 | 2.95e-07 | 4.23e-06 | 157 |
GO:00715609 | Esophagus | ESCC | cellular response to transforming growth factor beta stimulus | 151/8552 | 250/18723 | 1.78e-06 | 2.10e-05 | 151 |
GO:000716018 | Esophagus | ESCC | cell-matrix adhesion | 141/8552 | 233/18723 | 3.33e-06 | 3.71e-05 | 141 |
GO:005101727 | Esophagus | ESCC | actin filament bundle assembly | 100/8552 | 157/18723 | 3.87e-06 | 4.17e-05 | 100 |
GO:00071799 | Esophagus | ESCC | transforming growth factor beta receptor signaling pathway | 121/8552 | 198/18723 | 8.26e-06 | 8.03e-05 | 121 |
GO:006157227 | Esophagus | ESCC | actin filament bundle organization | 101/8552 | 161/18723 | 9.22e-06 | 8.82e-05 | 101 |
GO:00343418 | Esophagus | ESCC | response to interferon-gamma | 86/8552 | 141/18723 | 1.74e-04 | 1.14e-03 | 86 |
GO:003003820 | Esophagus | ESCC | contractile actin filament bundle assembly | 67/8552 | 106/18723 | 2.03e-04 | 1.28e-03 | 67 |
GO:004314920 | Esophagus | ESCC | stress fiber assembly | 67/8552 | 106/18723 | 2.03e-04 | 1.28e-03 | 67 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04510 | Colorectum | AD | Focal adhesion | 67/2092 | 203/8465 | 4.40e-03 | 2.17e-02 | 1.38e-02 | 67 |
hsa045101 | Colorectum | AD | Focal adhesion | 67/2092 | 203/8465 | 4.40e-03 | 2.17e-02 | 1.38e-02 | 67 |
hsa0451020 | Esophagus | ESCC | Focal adhesion | 127/4205 | 203/8465 | 1.25e-04 | 4.99e-04 | 2.56e-04 | 127 |
hsa04510111 | Esophagus | ESCC | Focal adhesion | 127/4205 | 203/8465 | 1.25e-04 | 4.99e-04 | 2.56e-04 | 127 |
hsa0451021 | Liver | Cirrhotic | Focal adhesion | 93/2530 | 203/8465 | 9.27e-07 | 1.10e-05 | 6.80e-06 | 93 |
hsa0451031 | Liver | Cirrhotic | Focal adhesion | 93/2530 | 203/8465 | 9.27e-07 | 1.10e-05 | 6.80e-06 | 93 |
hsa0451041 | Liver | HCC | Focal adhesion | 125/4020 | 203/8465 | 3.12e-05 | 1.88e-04 | 1.04e-04 | 125 |
hsa0451051 | Liver | HCC | Focal adhesion | 125/4020 | 203/8465 | 3.12e-05 | 1.88e-04 | 1.04e-04 | 125 |
hsa0451019 | Oral cavity | OSCC | Focal adhesion | 128/3704 | 203/8465 | 1.71e-08 | 1.63e-07 | 8.31e-08 | 128 |
hsa04510110 | Oral cavity | OSCC | Focal adhesion | 128/3704 | 203/8465 | 1.71e-08 | 1.63e-07 | 8.31e-08 | 128 |
hsa0451043 | Oral cavity | NEOLP | Focal adhesion | 71/1112 | 203/8465 | 7.25e-16 | 7.68e-14 | 4.83e-14 | 71 |
hsa0451053 | Oral cavity | NEOLP | Focal adhesion | 71/1112 | 203/8465 | 7.25e-16 | 7.68e-14 | 4.83e-14 | 71 |
hsa0451017 | Prostate | BPH | Focal adhesion | 85/1718 | 203/8465 | 1.17e-12 | 2.28e-11 | 1.41e-11 | 85 |
hsa0451018 | Prostate | BPH | Focal adhesion | 85/1718 | 203/8465 | 1.17e-12 | 2.28e-11 | 1.41e-11 | 85 |
hsa0451025 | Prostate | Tumor | Focal adhesion | 84/1791 | 203/8465 | 3.44e-11 | 6.69e-10 | 4.15e-10 | 84 |
hsa0451035 | Prostate | Tumor | Focal adhesion | 84/1791 | 203/8465 | 3.44e-11 | 6.69e-10 | 4.15e-10 | 84 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZYX | SNV | Missense_Mutation | novel | c.1348N>T | p.Pro450Ser | p.P450S | Q15942 | protein_coding | deleterious(0.03) | possibly_damaging(0.696) | TCGA-E9-A3HO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
ZYX | SNV | Missense_Mutation | novel | c.1421N>G | p.Ala474Gly | p.A474G | Q15942 | protein_coding | tolerated(0.14) | possibly_damaging(0.824) | TCGA-C5-A8YT-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
ZYX | SNV | Missense_Mutation | novel | c.467N>T | p.Asp156Val | p.D156V | Q15942 | protein_coding | tolerated(0.06) | benign(0.353) | TCGA-EK-A2GZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
ZYX | SNV | Missense_Mutation | rs758266725 | c.802N>G | p.Pro268Ala | p.P268A | Q15942 | protein_coding | tolerated(0.11) | benign(0.039) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZYX | SNV | Missense_Mutation | novel | c.737C>A | p.Ser246Tyr | p.S246Y | Q15942 | protein_coding | tolerated(0.39) | possibly_damaging(0.601) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ZYX | SNV | Missense_Mutation | c.320N>T | p.Ala107Val | p.A107V | Q15942 | protein_coding | deleterious(0.04) | benign(0.051) | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZYX | SNV | Missense_Mutation | novel | c.1216C>T | p.His406Tyr | p.H406Y | Q15942 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-F4-6461-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
ZYX | SNV | Missense_Mutation | novel | c.812C>A | p.Pro271His | p.P271H | Q15942 | protein_coding | deleterious(0) | possibly_damaging(0.841) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZYX | SNV | Missense_Mutation | rs569088357 | c.1516N>A | p.Val506Ile | p.V506I | Q15942 | protein_coding | deleterious(0) | possibly_damaging(0.506) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZYX | SNV | Missense_Mutation | novel | c.538C>A | p.Pro180Thr | p.P180T | Q15942 | protein_coding | deleterious(0.01) | probably_damaging(0.981) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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