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Gene: ZC3H15 |
Gene summary for ZC3H15 |
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Gene information | Species | Human | Gene symbol | ZC3H15 | Gene ID | 55854 |
Gene name | zinc finger CCCH-type containing 15 | |
Gene Alias | HT010 | |
Cytomap | 2q32.1 | |
Gene Type | protein-coding | GO ID | GO:0002181 | UniProtAcc | Q8WU90 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55854 | ZC3H15 | AEH-subject1 | Human | Endometrium | AEH | 1.49e-05 | -2.40e-01 | -0.3059 |
55854 | ZC3H15 | AEH-subject2 | Human | Endometrium | AEH | 6.59e-11 | -3.12e-01 | -0.2525 |
55854 | ZC3H15 | AEH-subject3 | Human | Endometrium | AEH | 8.04e-08 | -1.90e-01 | -0.2576 |
55854 | ZC3H15 | AEH-subject4 | Human | Endometrium | AEH | 6.42e-07 | -2.72e-01 | -0.2657 |
55854 | ZC3H15 | EEC-subject1 | Human | Endometrium | EEC | 1.46e-10 | -2.24e-01 | -0.2682 |
55854 | ZC3H15 | EEC-subject2 | Human | Endometrium | EEC | 1.56e-07 | -3.27e-01 | -0.2607 |
55854 | ZC3H15 | EEC-subject3 | Human | Endometrium | EEC | 1.41e-33 | -3.20e-01 | -0.2525 |
55854 | ZC3H15 | EEC-subject4 | Human | Endometrium | EEC | 2.48e-10 | -2.63e-01 | -0.2571 |
55854 | ZC3H15 | EEC-subject5 | Human | Endometrium | EEC | 2.58e-02 | -1.10e-01 | -0.249 |
55854 | ZC3H15 | GSM5276934 | Human | Endometrium | EEC | 3.62e-04 | 1.52e-01 | -0.0913 |
55854 | ZC3H15 | GSM5276937 | Human | Endometrium | EEC | 4.22e-03 | 1.85e-01 | -0.0897 |
55854 | ZC3H15 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 6.65e-36 | -2.35e-01 | -0.1869 |
55854 | ZC3H15 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 1.43e-37 | -1.71e-01 | -0.1875 |
55854 | ZC3H15 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.51e-42 | -1.35e-01 | -0.1883 |
55854 | ZC3H15 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 5.73e-37 | -1.18e-01 | -0.1934 |
55854 | ZC3H15 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 5.71e-63 | -2.36e-01 | -0.1917 |
55854 | ZC3H15 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 4.70e-53 | -2.49e-01 | -0.1916 |
55854 | ZC3H15 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 2.27e-14 | -2.82e-01 | -0.1269 |
55854 | ZC3H15 | LZE2T | Human | Esophagus | ESCC | 3.68e-02 | 8.75e-01 | 0.082 |
55854 | ZC3H15 | LZE4T | Human | Esophagus | ESCC | 5.73e-15 | 7.69e-01 | 0.0811 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00430879 | Prostate | BPH | regulation of GTPase activity | 88/3107 | 348/18723 | 2.04e-05 | 2.49e-04 | 88 |
GO:00435478 | Prostate | BPH | positive regulation of GTPase activity | 61/3107 | 255/18723 | 1.58e-03 | 9.23e-03 | 61 |
GO:000218119 | Prostate | Tumor | cytoplasmic translation | 115/3246 | 148/18723 | 1.36e-58 | 8.43e-55 | 115 |
GO:004308713 | Prostate | Tumor | regulation of GTPase activity | 88/3246 | 348/18723 | 1.04e-04 | 1.00e-03 | 88 |
GO:004354713 | Prostate | Tumor | positive regulation of GTPase activity | 60/3246 | 255/18723 | 6.87e-03 | 3.11e-02 | 60 |
GO:000218129 | Skin | cSCC | cytoplasmic translation | 127/4864 | 148/18723 | 4.83e-53 | 7.57e-50 | 127 |
GO:0002181113 | Thyroid | PTC | cytoplasmic translation | 121/5968 | 148/18723 | 4.32e-36 | 4.54e-33 | 121 |
GO:004308718 | Thyroid | PTC | regulation of GTPase activity | 148/5968 | 348/18723 | 1.63e-05 | 1.71e-04 | 148 |
GO:004354714 | Thyroid | PTC | positive regulation of GTPase activity | 103/5968 | 255/18723 | 2.38e-03 | 1.25e-02 | 103 |
GO:000218135 | Thyroid | ATC | cytoplasmic translation | 121/6293 | 148/18723 | 1.41e-33 | 1.49e-30 | 121 |
GO:004308719 | Thyroid | ATC | regulation of GTPase activity | 153/6293 | 348/18723 | 3.24e-05 | 2.68e-04 | 153 |
GO:004354715 | Thyroid | ATC | positive regulation of GTPase activity | 106/6293 | 255/18723 | 4.58e-03 | 1.89e-02 | 106 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZC3H15 | SNV | Missense_Mutation | c.586T>G | p.Trp196Gly | p.W196G | Q8WU90 | protein_coding | tolerated(0.05) | benign(0.039) | TCGA-AR-A250-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
ZC3H15 | SNV | Missense_Mutation | c.941N>G | p.Tyr314Cys | p.Y314C | Q8WU90 | protein_coding | tolerated(0.07) | benign(0.102) | TCGA-AR-A255-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Targeted Molecular therapy | trastuzumab | SD | |
ZC3H15 | SNV | Missense_Mutation | c.913N>A | p.Asp305Asn | p.D305N | Q8WU90 | protein_coding | tolerated(0.06) | probably_damaging(0.971) | TCGA-B6-A0I8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
ZC3H15 | SNV | Missense_Mutation | novel | c.970N>C | p.Asp324His | p.D324H | Q8WU90 | protein_coding | deleterious(0.01) | possibly_damaging(0.518) | TCGA-C8-A8HQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZC3H15 | SNV | Missense_Mutation | rs758813880 | c.1045G>T | p.Val349Leu | p.V349L | Q8WU90 | protein_coding | tolerated(0.24) | benign(0.003) | TCGA-E9-A295-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
ZC3H15 | SNV | Missense_Mutation | novel | c.424N>C | p.Asp142His | p.D142H | Q8WU90 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-OL-A5RW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
ZC3H15 | insertion | Nonsense_Mutation | novel | c.65_66insTTAACTGGCCCGGCAGGAAAAGTTTCCC | p.Lys22AsnfsTer2 | p.K22Nfs*2 | Q8WU90 | protein_coding | TCGA-A8-A085-01 | Breast | breast invasive carcinoma | Male | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
ZC3H15 | insertion | Frame_Shift_Ins | novel | c.232_233insC | p.Leu78SerfsTer6 | p.L78Sfs*6 | Q8WU90 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZC3H15 | insertion | Frame_Shift_Ins | novel | c.233_234insA | p.Gln79AlafsTer5 | p.Q79Afs*5 | Q8WU90 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZC3H15 | SNV | Missense_Mutation | c.57G>C | p.Lys19Asn | p.K19N | Q8WU90 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-EK-A2RA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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