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Gene: YARS |
Gene summary for YARS |
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Gene information | Species | Human | Gene symbol | YARS | Gene ID | 8565 |
Gene name | tyrosyl-tRNA synthetase 1 | |
Gene Alias | CMTDIC | |
Cytomap | 1p35.1 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | A0A0S2Z4R1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8565 | YARS | CCI_1 | Human | Cervix | CC | 3.21e-13 | 5.15e-01 | 0.528 |
8565 | YARS | CCI_2 | Human | Cervix | CC | 8.30e-15 | 5.63e-01 | 0.5249 |
8565 | YARS | CCI_3 | Human | Cervix | CC | 2.02e-15 | 4.92e-01 | 0.516 |
8565 | YARS | CCII_1 | Human | Cervix | CC | 1.30e-02 | 1.31e-01 | 0.3249 |
8565 | YARS | Tumor | Human | Cervix | CC | 7.94e-12 | 2.56e-01 | 0.1241 |
8565 | YARS | sample3 | Human | Cervix | CC | 1.08e-20 | 2.97e-01 | 0.1387 |
8565 | YARS | T1 | Human | Cervix | CC | 3.02e-05 | 1.51e-01 | 0.0918 |
8565 | YARS | T3 | Human | Cervix | CC | 3.00e-14 | 2.82e-01 | 0.1389 |
8565 | YARS | LZE4T | Human | Esophagus | ESCC | 1.07e-08 | 2.40e-01 | 0.0811 |
8565 | YARS | LZE5T | Human | Esophagus | ESCC | 8.37e-03 | 2.23e-01 | 0.0514 |
8565 | YARS | LZE7T | Human | Esophagus | ESCC | 9.19e-07 | 4.66e-01 | 0.0667 |
8565 | YARS | LZE8T | Human | Esophagus | ESCC | 2.68e-06 | 1.90e-01 | 0.067 |
8565 | YARS | LZE24D1 | Human | Esophagus | HGIN | 1.27e-03 | 4.19e-01 | 0.054 |
8565 | YARS | LZE24T | Human | Esophagus | ESCC | 3.89e-11 | 5.32e-01 | 0.0596 |
8565 | YARS | LZE21T | Human | Esophagus | ESCC | 7.07e-08 | 4.91e-01 | 0.0655 |
8565 | YARS | LZE6T | Human | Esophagus | ESCC | 3.18e-06 | 2.44e-01 | 0.0845 |
8565 | YARS | P1T-E | Human | Esophagus | ESCC | 1.61e-11 | 4.62e-01 | 0.0875 |
8565 | YARS | P2T-E | Human | Esophagus | ESCC | 5.21e-47 | 8.80e-01 | 0.1177 |
8565 | YARS | P4T-E | Human | Esophagus | ESCC | 6.94e-17 | 5.01e-01 | 0.1323 |
8565 | YARS | P5T-E | Human | Esophagus | ESCC | 4.80e-26 | 5.45e-01 | 0.1327 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:014005312 | Oral cavity | LP | mitochondrial gene expression | 53/4623 | 108/18723 | 3.54e-08 | 1.27e-06 | 53 |
GO:003466013 | Skin | cSCC | ncRNA metabolic process | 234/4864 | 485/18723 | 1.37e-26 | 4.77e-24 | 234 |
GO:00325436 | Skin | cSCC | mitochondrial translation | 47/4864 | 76/18723 | 4.70e-11 | 2.22e-09 | 47 |
GO:01400535 | Skin | cSCC | mitochondrial gene expression | 56/4864 | 108/18723 | 8.06e-09 | 2.56e-07 | 56 |
GO:00063993 | Skin | cSCC | tRNA metabolic process | 64/4864 | 179/18723 | 2.34e-03 | 1.36e-02 | 64 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
YARS | SNV | Missense_Mutation | novel | c.967N>T | p.Pro323Ser | p.P323S | P54577 | protein_coding | deleterious(0.01) | possibly_damaging(0.615) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
YARS | SNV | Missense_Mutation | c.988N>G | p.Thr330Ala | p.T330A | P54577 | protein_coding | tolerated(0.34) | benign(0) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
YARS | SNV | Missense_Mutation | rs752992202 | c.973N>T | p.Arg325Trp | p.R325W | P54577 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-E2-A2P6-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
YARS | insertion | Frame_Shift_Ins | novel | c.951_952insTCTCAAAA | p.Asn318SerfsTer19 | p.N318Sfs*19 | P54577 | protein_coding | TCGA-A8-A06O-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | letrozole | SD | ||
YARS | insertion | Frame_Shift_Ins | novel | c.950_951insCCAGCCTGGGCAACAGAGTGAGACTCTAT | p.Asn318GlnfsTer10 | p.N318Qfs*10 | P54577 | protein_coding | TCGA-A8-A06O-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | letrozole | SD | ||
YARS | insertion | Frame_Shift_Ins | novel | c.1188_1189insAAGAAAAGAAATGATGAGGCCAGGATTG | p.Ala397LysfsTer11 | p.A397Kfs*11 | P54577 | protein_coding | TCGA-A8-A099-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | exemestane | SD | ||
YARS | SNV | Missense_Mutation | c.1455G>C | p.Lys485Asn | p.K485N | P54577 | protein_coding | deleterious(0.03) | probably_damaging(0.923) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
YARS | SNV | Missense_Mutation | novel | c.1417G>A | p.Glu473Lys | p.E473K | P54577 | protein_coding | tolerated_low_confidence(0.06) | benign(0.036) | TCGA-UC-A7PG-06 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | PD |
YARS | insertion | In_Frame_Ins | novel | c.1490_1491insGATCCTGGG | p.Ile497delinsMetIleLeuGly | p.I497delinsMILG | P54577 | protein_coding | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | ||
YARS | SNV | Missense_Mutation | novel | c.79N>A | p.Leu27Met | p.L27M | P54577 | protein_coding | tolerated(0.19) | benign(0.063) | TCGA-AA-3870-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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